 | | Vol. 9.43 – 18 November, 2020 |
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| Using a genome-wide CRISPR-Cas9 screen for effectors of CC-90009 response, researchers uncovered the ILF2 and ILF3 heterodimeric complex as a novel regulator of cereblon expression. Knockout of ILF2/ILF3 decreased the production of full-length cereblon protein via modulating CRBN mRNA alternative splicing, leading to diminished response to CC-90009.
[Blood] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators introduced nickel-based functionalized nanoprobe facilitated surface enhanced Raman scattering (SERS) for prediction of cancer dissemination by undertaking CSC-based surveillance. SERS profiling of CSCs of various cell lines was compared with their cancer counterparts for the prediction of prognosis, with statistical significance of single-cell sensitivity.
[ACS Nano] |
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| Scientists report the integrated use of nanoparticle engineering and hypothesis-free sensing to identify nanoparticles capable of efficient differentiation of CSCs into non-CSC phenotypes.
[ACS Nano] |
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| The authors explored the mechanisms by which lncRNA derived from hypoxic glioma stem cells cause glioma progression. Isolation and identification of the Linc01060 gene, the exosomes containing them, and the proteins from tumor cells regulating the gene allowed for studying the effects of Linc01060 on proliferation and glycometabolism.
[Cancer Research] |
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| Researchers showed that as breast tumor-initiating cells formed, a decrease in cell-cycle and increase in self-renewal gene expression was coregulated by SOX2 and EZH2, which colocalized at CpG islands.
[Cancer Research] |
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| The authors did not observe a spike in circulating tumor (ct) DNA as a sign of a responsive tumor, but instead ctDNA levels initially decreased and remained low in patients with stable disease or partial response.
[npj Precision Oncology] |
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| Deregulation of PARK7 has been implicated in the pathogenesis of various human diseases, including cancer. Scientists clarified the effect of PARK7 on stemness and radioresistance of glioblastoma stem cells.
[Oncogene] |
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| Researchers found that leukemic stem cells were highly differentiated, and leukemia progression was severely impaired in the absence of adenosyl methionine decarboxylase (AMD1) in vivo.
[Oncogene] |
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| The authors observed that lncRNA NEAT1 was associated with 5-fluorouracil (5-Fu) resistance in colorectal cancer. They showed that NEAT1 promoted 5-Fu resistance in colorectal cells.
[Cell Death & Disease] |
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| Scientists showed that in pancreatic tumors, the developing stroma increased tumor initiation frequency in pancreatic cancer cells in vivo by enriching for CD133+ aggressive “stem-like” cells.
[Cell Death & Disease] |
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| Researchers used a natural product-inspired drug discovery approach to identify new compounds that phenotypically mimic the anti-CSC activity of oleacein.
[Aging] |
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| The authors summarize the current state of CSCs in glioblastoma using key concepts of evolution as a paradigm to describe how the CSC state is subject to alterations of cell intrinsic and extrinsic interactions that shape their evolutionarily trajectory.
[Neuro-Oncology] |
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| PharmaTher, Inc. has filed a provisional patent application with the US Patent and Trademark Office outlining the potential novel use of psilocybin to treat cancer, which was discovered by panaceAI™, their proprietary psychedelic drug repurposing artificial intelligence platform.
[PharmaTher, Inc. (GlobeNewswire, Inc.)] |
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| Innate Pharma SA announced that the European Medicines Agency granted PRIME designation to lacutamab, the company’s proprietary first-in-class anti-KIR3DL2 humanized cytotoxicity-inducing antibody, for the treatment of patients with relapsed or refractory Sézary syndrome who have received at least two prior systemic therapies.
[Innate Pharma SA] |
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| June 10-11, 2021
London, England, United Kingdom |
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| | Queen Mary University of London – London, England, United Kingdom |
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| | Peking University Shenzhen Graduate School – Shenzhen, China |
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| | NYU Langone Medical Center – New York, New York, United States |
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| | IRCCS Candiolo Cancer Institute – Candiolo, Italy |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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Cancer Stem Cell News
Cell Therapy News
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