Cancer Stem Cell News Volume 9.43 | Nov 18 2020







2020-11-18 | CSCN 9.43


Cancer Stem Cell News by STEMCELL Technologies
Vol. 9.43 – 18 November, 2020
TOP STORY

CC-90009, a Novel Cereblon E3 Ligase Modulator Targets Acute Myeloid Leukemia Blasts and Leukemia Stem Cells

Using a genome-wide CRISPR-Cas9 screen for effectors of CC-90009 response, researchers uncovered the ILF2 and ILF3 heterodimeric complex as a novel regulator of cereblon expression. Knockout of ILF2/ILF3 decreased the production of full-length cereblon protein via modulating CRBN mRNA alternative splicing, leading to diminished response to CC-90009.
[Blood]

Abstract


Learn more about cGMP-manufactured StemSpan™-ACF Without Phenol Red for culturing hematopoietic cell therapy products
PUBLICATIONSRanked by the impact factor of the journal

Prediction
of Cancer Stem Cell Fate by Surface-Enhanced Raman Scattering Functionalized Nanoprobes

Investigators introduced nickel-based functionalized nanoprobe facilitated surface enhanced Raman scattering (SERS) for prediction of cancer dissemination by undertaking CSC-based surveillance. SERS profiling of CSCs of various cell lines was compared with their cancer counterparts for the prediction of prognosis, with statistical significance of single-cell sensitivity.
[ACS Nano]

AbstractGraphical Abstract

Differentiation of Cancer Stem Cells through Nanoparticle Surface Engineering

Scientists report the integrated use of nanoparticle engineering and hypothesis-free sensing to identify nanoparticles capable of efficient differentiation of CSCs into non-CSC phenotypes.
[ACS Nano]

AbstractPress Release

Hypoxic
Glioma Stem Cell-Derived Exosomes Containing Linc01060 Promote Progression of Glioma by Regulating the MZF1/C-Myc/HIF-1α

The authors explored the mechanisms by which lncRNA derived from hypoxic glioma stem cells cause glioma progression. Isolation and identification of the Linc01060 gene, the exosomes containing them, and the proteins from tumor cells regulating the gene allowed for studying the effects of Linc01060 on proliferation and glycometabolism.
[Cancer Research]

Abstract

SCIRT
lncRNA Restrains Tumorigenesis by Opposing Transcriptional Programs of Tumor-Initiating Cells

Researchers showed that as breast tumor-initiating cells formed, a decrease in cell-cycle and increase in self-renewal gene expression was coregulated by SOX2 and EZH2, which colocalized at CpG islands.
[Cancer Research]

Abstract

On-Treatment
Measurements of Circulating Tumor DNA during FOLFOX Therapy in Patients with Colorectal Cancer

The authors did not observe a spike in circulating tumor (ct) DNA as a sign of a responsive tumor, but instead ctDNA levels initially decreased and remained low in patients with stable disease or partial response.
[npj Precision Oncology]

Abstract

PARK7
Maintains the Stemness of Glioblastoma Stem Cells by Stabilizing Epidermal Growth Factor Receptor Variant III

Deregulation of PARK7 has been implicated in the pathogenesis of various human diseases, including cancer. Scientists clarified the effect of PARK7 on stemness and radioresistance of glioblastoma stem cells.
[Oncogene]

Abstract

AMD1
Is Required for the Maintenance of Leukemic Stem Cells and Promotes Chronic Myeloid Leukemic Growth

Researchers found that leukemic stem cells were highly differentiated, and leukemia progression was severely impaired in the absence of adenosyl methionine decarboxylase (AMD1) in vivo.
[Oncogene]

Abstract

LncRNA
NEAT1 Remodels Chromatin to Promote the 5-Fu Resistance by Maintaining Colorectal Cancer Stemness

The authors observed that lncRNA NEAT1 was associated with 5-fluorouracil (5-Fu) resistance in colorectal cancer. They showed that NEAT1 promoted 5-Fu resistance in colorectal cells.
[Cell Death & Disease]

Full Article

Stroma
Secreted IL6 Selects for “Stem-Like” Population and Alters Pancreatic Tumor Microenvironment by Reprogramming Metabolic Pathways

Scientists showed that in pancreatic tumors, the developing stroma increased tumor initiation frequency in pancreatic cancer cells in vivo by enriching for CD133+ aggressive “stem-like” cells.
[Cell Death & Disease]

Full Article

Mimetics of Extra Virgin Olive Oil Phenols with Anti-Cancer Stem Cell Activity

Researchers used a natural product-inspired drug discovery approach to identify new compounds that phenotypically mimic the anti-CSC activity of oleacein.
[Aging]

Abstract

How have LSCs changed our understanding of myeloid malignancies? Webinar by Dr. Christopher Park, NYU
REVIEWS

The
Evolution of the Cancer Stem Cell State in Glioblastoma – Emerging Insights into the Next-Generation of Functional Interactions

The authors summarize the current state of CSCs in glioblastoma using key concepts of evolution as a paradigm to describe how the CSC state is subject to alterations of cell intrinsic and extrinsic interactions that shape their evolutionarily trajectory.
[Neuro-Oncology]

Abstract
INDUSTRY AND POLICY NEWS

PharmaTher Expands Patent Portfolio with Filing of US Patent for Novel Use of Psilocybin to Treat Cancer

PharmaTher, Inc. has filed a provisional patent application with the US Patent and Trademark Office outlining the potential novel use of psilocybin to treat cancer, which was discovered by panaceAI™, their proprietary psychedelic drug repurposing artificial intelligence platform.
[PharmaTher, Inc. (GlobeNewswire, Inc.)]

Press Release

Innate Pharma Receives Prime Designation from the European Medicines Agency for Lacutamab in Sézary Syndrome

Innate Pharma SA announced that the European Medicines Agency granted PRIME designation to lacutamab, the company’s proprietary first-in-class anti-KIR3DL2 humanized cytotoxicity-inducing antibody, for the treatment of patients with relapsed or refractory Sézary syndrome who have received at least two prior systemic therapies.
[Innate Pharma SA]

Press Release
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June 10-11, 2021
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JOB OPPORTUNITIES

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Queen Mary University of London – London, England, United Kingdom

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NYU Langone Medical Center – New York, New York, United States

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IRCCS Candiolo Cancer Institute – Candiolo, Italy

Clinical
Research Associate – Hematology, Oncology, and Bone Marrow Transplantation

The University of British Columbia – Vancouver, British Columbia, Canada

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