 | | Vol. 9.44 – 25 November, 2020 |
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| The authors showed that single circulating tumor cells from melanoma patients coordinately upregulated lipogenesis and iron homeostasis pathways.
[Cancer Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| S100A9 expression in tumor tissues was associated with poor survival of hepatocellular carcinoma patients. It could enhance the stem cell‐like properties of HepG2 and MHCC‐97H cells by activating nuclear factor‐kappa B signaling pathway through advanced glycosylation end product‐specific receptor in a Ca2+‐dependent manner.
[International Journal of Cancer] |
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| Organoid-derived CD44(−) cancer cells were capable of organoid re-formation and could be re-programed as CD44-expressing cancer-initiating cells in the organoid culture system.
[Cancer Letters] |
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| Scientists revealed that the metabolic profiles in gastric cancer tissues were altered. S-adenosylmethionine, a universal methyl donor for histone and DNA methylation, which is specifically involved in the epigenetic maintenance of cancer cells, was found increased.
[Oncogenesis] |
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| Using Western blotting and qRT-PCR analyses, investigators revealed that in the T47D and BT20 breast cancer cell lines, astaxanthin inhibited expression of pontin and mutp53, as well as the Oct4 and Nanog CSC stemness genes.
[Marine Drugs] |
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| Researchers evaluated the presence of breast CSCs as well as markers related to drug resistance in tumors obtained from 78 patients who had received (or not) chemotherapy before surgery.
[Scientific Reports] |
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| The authors investigated the prognostic value of automated circulating tumor cell (CTC) and tumor-derived extracellular vesicle enumeration and their dynamics, in patients with metastatic castration-resistant prostate cancer in the context of the initiation of treatment with androgen receptor signaling inhibitors.
[Prostate Cancer and Prostatic Diseases] |
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| The relationship among lncRNA FOXD3-AS1, miR-185-3p, and FOXD3 was identified with bioinformatics prediction, dual-luciferase reporter gene assays, RNA-binding protein immunoprecipitation, and RNA pull-down assays.
[Cancer Gene Therapy] |
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| Researchers found definite lipidomic and transcriptomic changes in the hepatocellular carcinoma lines upon knockdown of macroH2A1 or FAK, in line with the acquisition or loss of stemness features.
[International Journal of Molecular Sciences] |
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| Investigators report original findings on expression and prognostic significance of CSC markers in several cancers. They examined and compared the transcriptional expression of CSC markers in tumor tissues versus the adjacent normal tissues using publicly available databases, The Cancer Genome Atlas and Gene Expression Profiling Interactive Analysis.
[Omics-A Journal of integrative Biology] |
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| Accumulating evidence suggests that tumors arise from cells with stem‐like properties, the generation of CSCs is therefore likely to be an initiatory event in carcinogenesis
[International Journal of Cancer] |
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| Scientists discuss their coordinated regulation in the elimination of CSCs, with respect to stemness and differentiation of the CSC phenotype, and the different aspects of tumorigenesis such as cancer initiation, progression, resistance, and tumor relapse.
[Cancer Letters] |
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| BeiGene, Ltd. announced that the China National Medical Products Administration has approved XGEVA® for the prevention of skeletal-related events in patients with bone metastases from solid tumors and in patients with multiple myeloma.
[BeiGene, Ltd.] |
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| GT Medical Technologies, Inc. announced it has raised $16 million in a Series B financing led by MVM Partners with participation from existing investors MedTech Venture Partners and BlueStone Venture Partners. Funds from the round will support the expanded commercialization of GammaTile® Therapy, an FDA-cleared, Surgically Targeted Radiation Therapy for patients with brain tumors.
[GT Medical Technologies, Inc. (Business Wire, Inc.)] |
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| April 9 – April 14, 2021
Virtual |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Queen Mary University of London – London, England, United Kingdom |
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| | Peking University Shenzhen Graduate School – Shenzhen, China |
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| | NYU Langone Medical Center – New York, New York, United States |
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| | IRCCS Candiolo Cancer Institute – Candiolo, Italy |
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