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Vol. 11.20 – 25 May, 2022
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Hexokinase 2 enhanced the accumulation of acetyl-CoA and epigenetically activated the transcription of acyl-CoA synthetase long-chain family member 4 (ACSL4), leading to an increase in fatty acid β-oxidation activity.
[Advanced Science]
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PUBLICATIONSRanked by the impact factor of the journal
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The authors delineated the mechanistic actions of apurinic endonuclease (APE1)/IL-6 signaling in Erlotinib resistance of non-small cell lung cancer. [Clinical and Translational Medicine]
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Scientists demonstrated that cyclic AMP triggered neuronal differentiation and compromised the self-renewal capacity in glioma stem cells.
[Cell Death & Disease]
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Researchers found that glycogen synthase kinase 3β (GSK3β) was noted as a substrate for ZDHHC4-mediated palmitoylation at the Cys14 residue, which enhanced glioblastoma temozolomide resistance and glioblastoma stem cell self-renewal.
[Oncogenesis]
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Scientists showed that ΔNp63α expression was enhanced in sphere-forming colorectal cancer cells.
[Journal of Nutritional Biochemistry]
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A multiple-microtissue transcriptome analysis revealed three cancer cell-type clusters in the primary tumor and axillary lymph node metastasis of triple negative breast cancer, two of which were CSC-like clusters.
[Disease Models & Mechanisms]
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Researchers treated two human gastric cancer cell lines SGC7901 and BGC823 with 5-Fluorouracil or Cisplatin in vitro.
[Frontiers in Pharmacology]
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A novel recombinant protein fibronectin-collagen peptide was designed to modulate the function of extracellular matrix expressed by Picha. pastoris strain X33.
[Applied Microbiology and Biotechnology]
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Hypoxia induced by using CoCl2 application and 14-3-3β protein knockdown by specific small interfering RNA transfection were performed in GSCs both in vitro and in vivo to observe their role in glioma progression and metastasis occurrence by using western blot analysis and MTT assay.
[Journal of Immunology Research]
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Investigators focus on the early interaction between stem cells harboring mutations in cancer-driver genes and the surrounding tissue cells, which might also carry genetic mutations.
[Trends in Cell Biology]
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PharmaCyte Biotech, Inc. announced that it has initiated the first in a series of studies to test the ability of its pancreatic cancer therapy to treat malignant ascites.
[PharmaCyte Biotech, Inc.]
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September 19 – 20, 2022 Vejle, Denmark
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The University of Texas Southwestern Medical Center – Dallas, Texas, United States
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Duke University – Durham, North Carolina, United States
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Marlene and Stewart Greenebaum Comprehensive Cancer Center – Baltimore, Maryland, United States
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Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States
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Institute of Cancer Research – London, England, United Kingdom
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