Cancer Stem Cell News Volume 11.20 | May 25 2022

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    Britya Ghosh
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    2022-05-25 | CSCN 11.20


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.20 – 25 May, 2022
    TOP STORY

    CRISPR/Cas9 Screens Reveal That Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4-Fatty Acid β-Oxidation Pathway
    Hexokinase 2 enhanced the accumulation of acetyl-CoA and epigenetically activated the transcription of acyl-CoA synthetase long-chain family member 4 (ACSL4), leading to an increase in fatty acid β-oxidation activity.
    [Advanced Science]
    Full Article
    Dr. Kristina McBurney and Leanna Bedell discuss how you can use social media to advance your scientific career. Watch now.
    PUBLICATIONSRanked by the impact factor of the journal

    APE1 shRNA-Loaded Cancer Stem Cell-Derived Extracellular Vesicles Reverse Erlotinib Resistance in Non-Small Cell Lung Cancer via the IL-6/STAT3 Signaling
    The authors delineated the mechanistic actions of apurinic endonuclease (APE1)/IL-6 signaling in Erlotinib resistance of non-small cell lung cancer.
    [Clinical and Translational Medicine]
    Full Article

    Disruption of β-Catenin-Mediated Negative Feedback Reinforces cAMP-Induced Neuronal Differentiation in Glioma Stem Cells
    Scientists demonstrated that cyclic AMP triggered neuronal differentiation and compromised the self-renewal capacity in glioma stem cells.
    [Cell Death & Disease]
    Full Article

    GSK3β Palmitoylation Mediated by ZDHHC4 Promotes Tumorigenicity of Glioblastoma Stem Cells in Temozolomide-Resistant Glioblastoma through the EZH2–STAT3 Axis
    Researchers found that glycogen synthase kinase 3β (GSK3β) was noted as a substrate for ZDHHC4-mediated palmitoylation at the Cys14 residue, which enhanced glioblastoma temozolomide resistance and glioblastoma stem cell self-renewal.
    [Oncogenesis]
    Full Article

    ΔNp63α Mediates Sulforaphane Suppressed Colorectal Cancer Stem Cell Properties through Transcriptional Regulation of Nanog/Oct4/Sox2
    Scientists showed that ΔNp63α expression was enhanced in sphere-forming colorectal cancer cells.
    [Journal of Nutritional Biochemistry]
    Abstract

    Identification of Two Cancer Stem Cell-Like Populations in Triple-Negative Breast Cancer Xenografts
    A multiple-microtissue transcriptome analysis revealed three cancer cell-type clusters in the primary tumor and axillary lymph node metastasis of triple negative breast cancer, two of which were CSC-like clusters.
    [Disease Models & Mechanisms]
    Abstract

    GM-CSF-miRNA-Jak2/Stat3 Signaling Mediates Chemotherapy-Induced Cancer Cell Stemness in Gastric Cancer
    Researchers treated two human gastric cancer cell lines SGC7901 and BGC823 with 5-Fluorouracil or Cisplatin in vitro.
    [Frontiers in Pharmacology]
    Full Article

    Recombinant Expression a Novel Fibronectin-Collage Fusion Peptide Modulating Stem Cell Stemness via Integrin β3
    A novel recombinant protein fibronectin-collagen peptide was designed to modulate the function of extracellular matrix expressed by Picha. pastoris strain X33.
    [Applied Microbiology and Biotechnology]
    Full Article

    Hypoxia Promotes Glioma Stem Cell Proliferation by Enhancing the 14-3-3β Expression via the PI3K Pathway
    Hypoxia induced by using CoCl2 application and 14-3-3β protein knockdown by specific small interfering RNA transfection were performed in GSCs both in vitro and in vivo to observe their role in glioma progression and metastasis occurrence by using western blot analysis and MTT assay.
    [Journal of Immunology Research]
    Full Article
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    REVIEWS

    Reflected Stemness as a Potential Driver of the Tumor Microenvironment
    Investigators focus on the early interaction between stem cells harboring mutations in cancer-driver genes and the surrounding tissue cells, which might also carry genetic mutations.
    [Trends in Cell Biology]
    Abstract
    INDUSTRY AND POLICY NEWS

    PharmaCyte Biotech Initiates Studies to Confirm Its Pancreatic Cancer Therapy Can Treat Malignant Ascites
    PharmaCyte Biotech, Inc. announced that it has initiated the first in a series of studies to test the ability of its pancreatic cancer therapy to treat malignant ascites.
    [PharmaCyte Biotech, Inc.]
    Press Release
    FEATURED EVENT

    Danish Stem Cell Society (DASCS) 2022
    September 19 – 20, 2022
    Vejle, Denmark

    > See All Events
    JOB OPPORTUNITIES

    Postdoctoral Fellow – Molecular Mechanisms and Translational Cancer Research

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Fellow – Breast Cancer and Leukemia

    Duke University – Durham, North Carolina, United States

    Postdoctoral Fellow – Prostate Cancer Biology
    Marlene and Stewart Greenebaum Comprehensive Cancer Center – Baltimore, Maryland, United States

    Faculty Positions – Cancer Research
    Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States

    Scientific Officer – Cell Biology
    Institute of Cancer Research – London, England, United Kingdom

    > See All Jobs

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