Cancer Stem Cell News Volume 11.20 | May 25 2022


    2022-05-25 | CSCN 11.20

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.20 – 25 May, 2022

    CRISPR/Cas9 Screens Reveal That Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4-Fatty Acid β-Oxidation Pathway

    Hexokinase 2 enhanced the accumulation of acetyl-CoA and epigenetically activated the transcription of acyl-CoA synthetase long-chain family member 4 (ACSL4), leading to an increase in fatty acid β-oxidation activity.
    [Advanced Science]

    Full Article

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    APE1 shRNA-Loaded Cancer Stem Cell-Derived Extracellular Vesicles Reverse Erlotinib Resistance in Non-Small Cell Lung Cancer via the IL-6/STAT3 Signaling

    The authors delineated the mechanistic actions of apurinic endonuclease (APE1)/IL-6 signaling in Erlotinib resistance of non-small cell lung cancer.
    [Clinical and Translational Medicine]

    Full Article

    Disruption of β-Catenin-Mediated Negative Feedback Reinforces cAMP-Induced Neuronal Differentiation in Glioma Stem Cells

    Scientists demonstrated that cyclic AMP triggered neuronal differentiation and compromised the self-renewal capacity in glioma stem cells.
    [Cell Death & Disease]

    Full Article

    GSK3β Palmitoylation Mediated by ZDHHC4 Promotes Tumorigenicity of Glioblastoma Stem Cells in Temozolomide-Resistant Glioblastoma through the EZH2–STAT3 Axis

    Researchers found that glycogen synthase kinase 3β (GSK3β) was noted as a substrate for ZDHHC4-mediated palmitoylation at the Cys14 residue, which enhanced glioblastoma temozolomide resistance and glioblastoma stem cell self-renewal.

    Full Article

    ΔNp63α Mediates Sulforaphane Suppressed Colorectal Cancer Stem Cell Properties through Transcriptional Regulation of Nanog/Oct4/Sox2

    Scientists showed that ΔNp63α expression was enhanced in sphere-forming colorectal cancer cells.
    [Journal of Nutritional Biochemistry]


    Identification of Two Cancer Stem Cell-Like Populations in Triple-Negative Breast Cancer Xenografts

    A multiple-microtissue transcriptome analysis revealed three cancer cell-type clusters in the primary tumor and axillary lymph node metastasis of triple negative breast cancer, two of which were CSC-like clusters.
    [Disease Models & Mechanisms]


    GM-CSF-miRNA-Jak2/Stat3 Signaling Mediates Chemotherapy-Induced Cancer Cell Stemness in Gastric Cancer

    Researchers treated two human gastric cancer cell lines SGC7901 and BGC823 with 5-Fluorouracil or Cisplatin in vitro.
    [Frontiers in Pharmacology]

    Full Article

    Recombinant Expression a Novel Fibronectin-Collage Fusion Peptide Modulating Stem Cell Stemness via Integrin β3

    A novel recombinant protein fibronectin-collagen peptide was designed to modulate the function of extracellular matrix expressed by Picha. pastoris strain X33.
    [Applied Microbiology and Biotechnology]

    Full Article

    Hypoxia Promotes Glioma Stem Cell Proliferation by Enhancing the 14-3-3β Expression via the PI3K Pathway

    Hypoxia induced by using CoCl2 application and 14-3-3β protein knockdown by specific small interfering RNA transfection were performed in GSCs both in vitro and in vivo to observe their role in glioma progression and metastasis occurrence by using western blot analysis and MTT assay.
    [Journal of Immunology Research]

    Full Article


    Reflected Stemness as a Potential Driver of the Tumor Microenvironment

    Investigators focus on the early interaction between stem cells harboring mutations in cancer-driver genes and the surrounding tissue cells, which might also carry genetic mutations.
    [Trends in Cell Biology]



    PharmaCyte Biotech Initiates Studies to Confirm Its Pancreatic Cancer Therapy Can Treat Malignant Ascites

    PharmaCyte Biotech, Inc. announced that it has initiated the first in a series of studies to test the ability of its pancreatic cancer therapy to treat malignant ascites.
    [PharmaCyte Biotech, Inc.]

    Press Release


    Danish Stem Cell Society (DASCS) 2022

    September 19 – 20, 2022
    Vejle, Denmark

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    Postdoctoral Fellow – Molecular Mechanisms and Translational Cancer Research

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Fellow – Breast Cancer and Leukemia

    Duke University – Durham, North Carolina, United States

    Postdoctoral Fellow – Prostate Cancer Biology

    Marlene and Stewart Greenebaum Comprehensive Cancer Center – Baltimore, Maryland, United States

    Faculty Positions – Cancer Research

    Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States

    Scientific Officer – Cell Biology

    Institute of Cancer Research – London, England, United Kingdom

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