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Cells in Developing Tissue Consider Their Signaling Exposure History to Determine Location
Researchers have found that cells cannot adopt multiple patterns of gene expression solely by measuring the local concentration of a morphogen. [California Institute of Technology, Pasadena]
Article
What Makes the Same Type of Cells Different?
A research team has managed to decipher a well-known phenomenon of why cells of the same type can react differently and what the reason for this is. [ETH Zurich, Zurich]
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Stem Cell Success Points to Way to Regenerate Parathyroid Glands
The scientists in this study were able to induce embryonic stem cells to differentiate into parathyroid cells that produced a hormone essential to maintaining bone density. [University of Michigan, Ann Arbor]
Article
Improving Stem Cell Techniques Using Protein Found In Moss
Researchers describe an ancient mechanism that alters the way DNA organizes inside the cell nucleus, which in turn, affects gene expression. [Tel Aviv University, Tel Aviv]
Article
Stem Cells Point to Space Illness
Stem cells exposed to microgravity express different proteins than those grown in normal gravity, say Australian researchers. [University of New South Wales, Sydney]
Article
Scientists Discover Clues to What Makes Human Muscle Age
By manipulating a recently identified critical biochemical pathway, the researchers were able to turn back the clock on old human muscle, restoring its ability to repair and rebuild itself. [University of California-Berkeley, Berkeley]
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Cells Derived From Human Embryonic Stem Cells Reverse Retinal Degeneration
A new study reports that transplanted pigment-containing visual cells derived from human embryonic stem cells (hESCs) successfully preserved structure and function of the specialized light-sensitive lining of the eye (known as the retina) in an animal model of retinal degeneration. [Hadassah-Hebrew University Medical Center, Jerusalem]
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Cardiac Stem Cell Trial Seeks to Treat Some Heart Attack Patients
Researchers have begun enrollment for an early-stage clinical trial to evaluate the safety and efficacy of an adult stem cell therapy for patients who have just experienced their first acute myocardial infarction. [University of California-San Francisco, San Francisco]
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Excellent Stem Cell Mobilization and Safety Profile for TG-0054
TaiGen Biotechnology Co., Ltd. announced today that in a phase 1 study in healthy volunteers TG-0054, a chemokine receptor CXCR4 antagonist, was well tolerated and rapidly mobilized stem cells and endothelial progenitor cells from bone marrow into peripheral blood. [TaiGen Biotechnology Co., Ltd., Taipei]
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ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Generation of Induced Pluripotent Stem Cells from Human Cord Blood Using OCT4 and SOX2
In this study, the reprogramming of cord blood cells to pluripotency by retroviral transduction of four (OSKM), three (OSK), and as few as two (OS) transcription factors, without the need for additional chemical compounds are described. [Cell Stem Cell]
Article
JAK-STAT Signal Inhibition Regulates Competition in the Drosophila Testis Stem Cell Niche
In the Drosophila testis, Janus kinase–signal transducer and activator of transcription (JAK-STAT) signaling is directly required for maintenance of the resident germline and somatic stem cells. [Science]
Article
Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells
In the present study, the researchers aimed to characterize the cardiomyocyte differentiation potential of hiPS cells and to study the molecular, structural, and functional properties of the generated hiPS-derived cardiomyocytes. [Circulation]
Article
Induction of Stem Cell Gene Expression in Adult Human Fibroblasts without Transgenes
This study suggest that it is possible to induce and manipulate endogenous expression of stem cell genes in somatic cells without genetic manipulation, but this short-term induction may not be sufficient for acquisition of true pluripotency. [Cloning Stem Cells]
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