UCLA Researchers Demonstrate that Stem Cells can be Engineered to Kill HIV
Researchers from the UCLA AIDS Institute and colleagues have for the first time demonstrated that human blood stem cells can be engineered into cells that can target and kill HIV-infected cells — a process that potentially could be used against a range of chronic viral diseases. [University of California, Los Angeles, Los Angeles]
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New Skin Stem Cells Surprisingly Similar to Those Found in Embryos
Scientists have discovered a new type of stem cell in the skin that acts surprisingly like certain stem cells found in embryos: both can generate fat, bone, cartilage, and even nerve cells. [Howard Hughes Medical Institute, Chevy Chase]
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VIDEO: Supportive Materials will Help Regenerate Heart Tissue
Bioengineers are developing new regenerative therapies for heart disease that could influence the way in which regenerative therapies for cardiovascular and other diseases are treated in the future. New results identify the use of adult stem cells to regenerate heart tissue in environments that mimic a human post-heart-attack heart. [University of California-San Diego, San Diego]
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Stem Cells Battle for Space
Although the manner in which some cells compete for space and dominance is well known to be the survival of the fittest, researchers describe how stem cells win this battle by literally sticking around. [Johns Hopkins School of Medicine, Baltimore]
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Stem Cell Research Gives Hope to Stroke Patients
Stroke-damaged brains could be repaired within 5-10 years using adult stem cells from teeth, according to one of Australia’s leading stroke physicians. [Adelaide University’s Centre for Stem Cell Research, Adelaide]
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New Stem Cell Technology Leads to Better Treatment for Complicated Bone Fractures
The Hebrew University group has developed a technology called immuno-isolation in which mesenchymal stem cells are sorted out from the other cells residing in a bone marrow sample, using a specific antibody. It was shown that the immuno-isolated cells could be immediately used to form new bone tissue when implanted in laboratory animals, without having to undergo a prolonged incubator growth period. [Hebrew University of Jerusalem, Jerusalem]
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Umbilical Stem Cells May Help Recover Lost Vision for Those with Corneal Disease
New research has found that transplanting human umbilical mesenchymal stem cells into mouse models that lack the protein lumican restored the transparency of cloudy and thin corneas. [University of Cincinnati, Cincinnati]
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Gene Therapy and Stem Cells Save Limb
Researchers examined if HIF-1 gene therapy treatment, which includes activation of HIF-1 to build new blood vessels, could improve reduced blood flow associated with advanced age. [Johns Hopkins Medicine, Baltimore]
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Blood Stem Cell Transplant Regimen Reverses Sickle Cell Disease in Adults
A modified blood adult stem-cell transplant regimen has effectively reversed sickle cell disease in 9 of 10 adults who had been severely affected by the disease. [NIH Clinical Center, Bethesda]
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PUBLICATIONS, REVIEWS AND SPECIAL REPORTS
Signaling Pathways Controlling Pluripotency and Early Cell Fate Decisions of Human Induced Pluripotent Stem Cells
Scientists show that human induced pluripotent stem cells rely on activin/nodal signaling to control Nanog expression and thereby maintain pluripotency, thus revealing their mechanistic similarity to human embryonic stem cells. [Stem Cells]
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Complete Genetic Correction of iPS Cells From Duchenne Muscular Dystrophy
Researchers show the complete correction of a genetic deficiency in iPS cells derived from Duchenne muscular dystrophy model mice and a human DMD patient using a human artificial chromosome with a complete genomic dystrophin sequence. [Mol Ther]
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Preconditioning Mesenchymal Stem Cells With Transforming Growth Factor-Alpha Improves Mesenchymal Stem Cell-Mediated Cardioprotection
Transplanted cells encounter an inflammatory environment that mitigates their function and survival, so the researchers explored treating the cells with exogenous agents during ex vivo expansion before transplantation as one strategy for overcoming this limitation by enhancing paracrine function. [Shock]
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Differential Destruction of Stem Cells: Implications for Targeted Cancer Stem Cell Therapy
This study presents a mathematical model to predict how selective a therapy must be to ensure that enough hematopoietic stem cells survive when leukemic stem cells have been eradicated. [Cancer Res]
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iPS Cells: Mapping the Policy Issues
Given the explosion of research on induced pluripotent stem cells, it is timely to consider the various ethical, legal, and social issues engaged by this fast-moving field. Here, issues associated with the procurement, basic research, and clinical translation of iPS cells are reviewed. [Cell]
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