SCIENCE Scientists Identify Protein that Keeps Stem Cells Poised for Action Researchers have identified the role of Jarid2 in embryonic stem cells. Jarid2 was found to recruit other regulatory proteins to genes important in differentiation and also, modulate their activity to keep them in a state of ongoing readiness. [Stanford University School of Medicine, Stanford] Study Identifies a Protein Complex Possibly Crucial for Triggering Embryo Development Researchers have discovered a protein complex that appears to play a significant role in erasing epigenetic instructions on sperm DNA, essentially creating a blank slate for the different cell types of a new embryo to develop. [UNC School of Medicine, Chapel Hill] Growing Blood Vessels: Bioengineered Materials Promote the Growth of Functional Vasculature Using synthetic polymers called hydrogels, researchers have been able to induce significant vasculature growth in areas of damaged tissue. [Georgia Institute of Technology, Atlanta] Leukaemia Vaccine Being Developed Scientists have developed a vaccine treatment for Leukaemia that can be used to stop the disease returning after chemotherapy or bone marrow transplant. [King's College London, London] Geron Announces Publication of Data on its Telomerase Inhibitor in Glioblastoma Geron Corporation announced the publication of preclinical data demonstrating that its telomerase inhibitor drug, imetelstat (GRN163L), inhibited telomerase activity and reduced tumor size in xenograft models of glioblastoma, and inhibited the activity of glioblastoma stem cells in culture. [Geron Corporation, Menlo Park] Gene Therapy Makes Mice Breathe Easier: Preventing Progression of Emphysema Researchers have discovered a new gene therapy that may prevent the progression of emphysema. [Boston University School of Medicine, Boston] ReNeuron Press Release: Regulatory Update ReNeuron Group plc recently provided a regulatory update regarding its ReN001 stem cell therapy for stroke and its ReN009 stem cell therapy for peripheral arterial disease. [ReNeuron Group plc, Guildford] Advanced Cell Technology Provides Update on Clinical Trials Using Embryonic Stem Cells to Treat Eye Disease Advanced Cell Technology, Inc. announced that it has received notification from the US Food and Drug Administration that the Agency is currently drafting a response to the Company relating to the Investigational New Drug Application it filed in November seeking clearance to initiate a Phase I/II multicenter study using embryonic stem cell derived retinal cells to treat patients with Stargardt’s Macular Dystrophy. [Advanced Cell Technology, Inc., Worcester] Stem Cell Treatment Restores Sight to Partially Blind Man A man who was partially blinded when ammonia was squirted in his eye during an attack 15 years ago has regained his sight after receiving a pioneering stem cell treatment. [North East England Stem Cell Institute, Newcastle] PUBLICATIONS, REVIEWS AND SPECIAL REPORTS Human-Induced Pluripotent Stem Cells from Blood Cells of Healthy Donors and Patients with Acquired Blood Disorders Researchers report derivation of human-induced pluripotent stem cells from postnatal human blood cells and the potential of these pluripotent cells for disease modeling. [Blood] The Battle to Prevent the Transmission of Mitochondrial DNA Disease: Is Karyoplast Transfer the Answer? Recent advances in assisted reproductive technologies have provided opportunities to determine whether specific manipulations can be used to generate offspring free of their mother's transmissible mutant mtDNA. The researchers strongly suggest, however, that considerable caution should be taken when interpreting these results. [Gene Ther] Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro Lgr5 expression in the stomach was investigated and the stem cell potential of the Lgr5+ve cells by using in vivo lineage tracing was assessed. [Cell Stem Cell] Functional and Morphological Maturation of Implanted Neonatal Cardiomyocytes as a Comparator for Cell Therapy Knowledge of the rate of development of immature cardiomyocytes after implantation into a host heart is important for studies using cell therapy. To assess this functionally, researchers implanted rat neonatal cardiomyocytes in normal and infarcted rat heart and reisolated them for functional assessment. [Stem Cells Dev] China Surpasses Canada in Stem Cell Advances Scientists in China, many of them trained at North American and European universities, published 1,116 articles on stem cells in international peer-reviewed journals in 2008, up from just 37 papers in 2000, says a team at the University of Toronto documenting China's aggressive bid to become a major player in regenerative medicine.
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