SCIENCE NEWS Unpacking Condensins' Function in Embryonic Stem Cells Regulatory proteins common to all eukaryotic cells can have additional, unique functions in embryonic stem cells, according to a study. [Press release from ScienceDaily discussing the online prepublication in Journal of Cell Biology] University of Texas Health Science Center Research Shows Modified Adult Stem Cells May Be Helpful in Spinal Cord Injury Researchers at the University of Texas Health Science Center have demonstrated in rats that transplanting genetically modified adult stem cells into an injured spinal cord can help restore the electrical pathways associated with movement. [Press release from the University of Texas Health Science Center discussing the online prepublication in the Journal of Neuroscience] The Mouse with a Human Liver: a New Model for the Treatment of Liver Disease How do you study – and try to cure in the laboratory – an infection that only humans can get? A team led by Salk Institute researchers does it by generating a mouse with an almost completely human liver. [Press release from the Salk Institute discussing the online prepublication in the Journal of Clinical Investigation] Stem Cells Restore Sight in Mouse Model of Retinitis Pigmentosa An international research team successfully used mouse embryonic stem cells to replace diseased retinal cells and restore sight in a mouse model of retinitis pigmentosa. [Press release from Columbia University Medical Center discussing the online prepublication in Transplantation] Histostem Participates in Clinical Trials Demonstrating the Effective Use of Its Proprietary Stem Cells in the Treatment of Cirrhosis of the Liver AmStem Corporation announced that Histostem Ltd. of South Korea has participated in a successful preclinical study of the use of its proprietary human umbilical cord blood-derived mesenchymal stem cells in the treatment of cirrhosis of the liver. [CNN Money] Adult Stem Cell Therapy Shows Promise for Heart Attack Patients Wake Forest University Baptist Medical Center is participating in a national research study testing the restorative effect that adult bone marrow stem cells have on damaged heart muscle in heart attack patients. [Wake Forest University Baptist Medical Center Press Release] New Study Demonstrates Effectiveness of Prochymal as a Rescue Therapy for Pediatric Patients with Severe Graft vs. Host Disease Osiris Therapeutics, Inc. reported that a new study shows Prochymal achieved an overall response rate of 63% when used as a rescue therapy in children suffering from severe treatment resistant graft vs. host disease. [Osiris Therapeutics, Inc. Press Release] Investigators Present Phase III Data for Prochymal in Steroid-Refractory Graft vs. Host Disease Osiris Therapeutics, Inc. announced that results from the Phase III trial evaluating Prochymal for the treatment of steroid-refractory acute graft vs. host disease will be presented by Paul Martin, M.D., of the Fred Hutchinson Cancer Research Center and Paul Szabolcs, M.D., of Duke University Medical Center at the 2010 Blood and Marrow Transplant Tandem Meeting. [Osiris Therapeutics, Inc. Press Release] Aastrom Reports Interim Results from Critical Limb Ischemia Trial Aastrom Biosciences, Inc. reported results from a planned interim analysis of the company's multi-center, randomized, double-blind, placebo-controlled U.S. Phase IIb clinical trial designated RESTORE-CLI. [Aastrom Biosciences, Inc. Press Release] CURRENT PUBLICATIONS Regenerative Medicine: Cell Reprogramming Gets Direct Researchers describe a potential innovation for generating disease-specific and patient-specific tissues of the central nervous system that does not rely on stem cells. [Nature] Location of Corneal Epithelial Stem Cells Investigators point out that previous suggestions concerning the location of corneal epithelial stem cells are inconsistent with many known growth, differentiation and cell migration properties of the anterior ocular epithelia. [Nature] Dicer-Independent Primal RNAs Trigger RNAi and Heterochromatin Formation Results suggest that a transcriptome surveillance mechanism based on random association of RNA degradation products with Argonaute triggers siRNA amplification and heterochromatin assembly within DNA repeats. [Cell] Cortical Plasticity Induced by Inhibitory Neuron Transplantation Findings suggest that ocular dominance plasticity is regulated by the execution of a maturational program intrinsic to inhibitory neurons. [Science] Human Liver Chimeric Mice Provide a Model for Hepatitis B and C Virus Infection and Treatment Researchers have shown that a high transplantation dose (3 × 106 to 5 × 106 human hepatocytes/mouse) generates a higher rate of liver chimerism than was previously obtained in these mice, up to 95% human hepatocyte chimerism. [J Clin Invest] A Highly Efficient Short Hairpin RNA Potently Down-Regulates CCR5 Expression in Systemic Lymphoid Organs in the Human Bone Marrow/Liver/Thymus Mouse Model Researchers report stable knockdown of human CCR5 by a short hairpin RNA in a humanized bone marrow/liver/thymus mouse model. [Blood] Scl Isoforms Act Downstream of Etsrp to Specify Angioblasts and Definitive Hematopoietic Stem Cells Data suggest that downstream of etsrp, scl-(alpha) and fli1a specify the angioblasts, while scl-(beta) further initiates hematopoietic stem cells specification from this angioblast population, and that Vegf signaling acts upstream of scl-(beta) during definitive hematopoiesis. [Blood] Condensin Complexes Regulate Mitotic Progression and Interphase Chromatin Structure in Embryonic Stem Cells In this study, researchers show that for Smc2 and -4, as well as an additional 49 of 62 previously identified genes required for embryonic stem cell viability, knockdown in somatic cells had minimal effects on proliferation or viability. [J Cell Biol] Transplantation of Ciliary Neurotrophic Factor-Expressing Adult Oligodendrocyte Precursor Cells Promotes Remyelination and Functional Recovery after Spinal Cord Injury Researchers explored whether the combination of neurotrophic factors and transplantation of adult rat spinal cord oligodendrocyte precursor cells could enhance remyelination and functional recovery after spinal cord injury. [J Neurosci] Transplantation of Reprogrammed Embryonic Stem Cells Improves Visual Function in a Mouse Model for Retinitis Pigmentosa Retinal pigment epithelia (RPE)-like cells derived from embryonic stem cells sequentially express multiple RPE-specific markers. [Transplantation]
|