SCIENCE NEWSNew Discovery Could Speed Up Liver Repair
West Australian scientists have discovered a way to double the speed of liver cell growth, which could herald the beginning of new regeneration treatment for patients with liver damage and make transplantations a thing of the past. [Press release from Western Australian Institute for Medical Research discussing online prepublication in Hepatology] New Tool Developed for DNA Research
Researchers have developed a tool which could solve two main problems with luminescent DNA markers: A tool that you might call a molecular gauge. [Press release from University of Copenhagen discussing online prepublication in Journal of the American Chemical Society] Recent Advances Lead to a Breakthrough Method for Expanded Medical Use of Adult Stem Cells
At a recent scientific symposium, Vitro Diagnostics, Inc. scientists presented their evidence that expression of a single gene within adult stem cells resulted in expanded differentiation capacity comparable to embryonic stem cells that have the capacity to differentiate into any cell of the body. [Market Wire Press Release] Supplement Your Stem Cells
Recent research suggests that a commercially-available supplement can increase the blood circulation of hematopoietic stem cells, which can give rise to all blood cells, and endothelial progenitor cells. [Press release from EurekAlert! discussing online prepublication in Journal of Translational Medicine] New Study on Promise of Gene Therapy for Leber Congenital Amaurosis
In a recent study published recently researchers found that only a limited number of patients possess the exact genetic mutation necessary for a positive outcome from therapy for Leber Congenital Amaurosis. [Press release from EurekAlert! discussing online prepublication in Journal of American Association for Pediatric Ophthalmology and Strabismus] Researchers Grow High Purity Liver Tissue from Stem Cells
A research group has developed a new method for growing liver tissue using Induced Pluripotent Stem cells, resulting in high purity cells that have high expectations for medical application. [The Mainichi Daily News] Magnetic Attraction of Stem Cells Creates More Potent Treatment for Heart Attack
Researchers have found in animals that infusing cardiac-derived stem cells with micro-size particles of iron and then using a magnet to guide those stem cells to the area of the heart damaged in a heart attack boosts the heart's retention of those cells and could increase the therapeutic benefit of stem cell therapy for heart disease. [Press release from EurekAlert! discussing online prepublication in Circulation Research] Scientists Grow Replacement Blood Vessels from Stem Cells
Blood vessels engineered from laboratory-grown stem cells have worked well in animals, researchers say, and might someday replace the synthetic products now in use. [HealthDay Press Release] Stem Cell Treatment Shows Early Promise: Celgene
Celgene Corp. said recently that its experimental stem cell treatment showed promise in a tiny, Phase I study of patients with Crohn's disease who failed to respond to prior therapy, according to initial results. [Reuters Press Release] Brain Tumor-Causing Stem Cells Also Found to Have Role in Severe Epilepsy
Researchers have published a study that identifies a group of abnormal stem cells that contribute to severe epilepsy in children. [University College of London Institute of Child Health Press Release] Living Cell Technologies Confirms Safety and Proof of Principle of Efficacy in its Penultimate Data Analysis from its Russian Human Phase I/IIa Trial with DIABECELL® in Diabetics
Living Cell Technologies has confirmed that the three-year follow up of its Phase I/IIa clinical trial in Russia of its DIABECELL® treatment in insulin-dependent diabetics has successfully met its end points of demonstrating safety and tolerability. [Living Cell Technologies Limited Press Release] CURRENT PUBLICATIONSStem Cells: Skin Regeneration and Repair
Different types of stem cell maintain the skin's epidermis and contribute to its healing after damage. The identity of a stem-cell type that gives rise to different epidermal-cell lineages has just been revealed. [Nature] Control of Mammary Stem Cell Function by Steroid Hormone Signaling
Researchers demonstrate that mouse mammary stem cells are highly responsive to steroid hormone signaling, despite lacking the oestrogen and progesterone receptors. [Nature] An Expanded Oct4 Interaction Network: Implications for Stem Cell Biology, Development, and Disease
Researchers find that Oct4 associates with a varied set of proteins including regulators of gene expression and modulators of Oct4 function. [Cell Stem Cell] Clinical and Immunological Outcome of Patients with Cartilage Hair Hypoplasia After Hematopoietic Stem Cell Transplantation
Since long-term experience in larger cohorts of cartilage-hair hypoplasia (CHH) patients after hematopoietic stem cell transplantation (HSCT) is currently unreported, researchers performed a European collaborative survey reporting on 16 patients with CHH and immunodeficiency who underwent HSCT. [Blood] Magnetic Targeting Enhances Engraftment and Functional Benefit of Iron-Labeled Cardiosphere-Derived Cells in Myocardial Infarction
Investigators sought to counter the efflux of transplanted cells by rendering them magnetically responsive and imposing an external magnetic field on the heart during and immediately after injection. [Circ Res] Epigenetic Stability Increases Extensively During Drosophila Follicle Stem Cell Differentiation
Results suggest that stem/early progenitor cells cannot accurately transmit nongenetic information to their progeny; full epigenetic competence is acquired only gradually during early differentiation. [Proc Natl Acad Sci U S A] A Unique Fluorescent Base Analogue for the Expansion of the Genetic Alphabet
Researchers present a novel fluorescent purine analogue, 7-(2,2'-bithien-5-yl)-imidazo[4,5-b]pyridine (Dss). Dss would be a powerful tool for fluorescent base replacements at specific positions in functional DNA and RNA molecules. [J Am Chem Soc] Nutraceutical Augmentation of Circulating Endothelial Progenitor Cells and Hematopoietic Stem Cells in Human Subjects
Data suggest Stem-Kine supplementation may be useful as a stimulator of reparative processes associated with mobilization of hematopoietic and endothelial progenitors. [J Transl Med]
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