SCIENCE NEWSDefects in Immune System Enzyme May Increase Risk of Autoimmune Disorders
A multi-institutional research team has found that rare variants in the gene coding an enzyme that controls the activity of a key immune cell occur more frequently in individuals with autoimmune disorders like rheumatoid arthritis and type 1 diabetes. [Press release from Massachusetts General Hospital Center for Regenerative Medicine discussing online prepublication in Nature]Gamma Interferon Prompts Stem Cell Response to Fight Infection
Findings show that gamma interferon not only activates stem cells during infection, but also regulates stem cells in normal times, enabling them to maintain the types of blood cells that exist in proportion or homeostasis. [Press release from the Baylor College of Medicine discussing online prepublication in Nature] Scientists Identify Three New Genetic Variants That Increase Testicular Cancer Risk
A study led by the Institute of Cancer Research has identified three new genetic risk factors for testicular cancer, taking the number of genomic regions known to be associated with testicular cancer risk to six. [Press release from the Wellcome Trust discussing online prepublication in Nature Genetics] Adding Nucleic Acid Testing to HIV Screening May Help Identify More People with HIV
Researchers showed that nucleic acid testing increased the HIV detection yield by 23%. [Press release from the University of California, San Diego discussing online prepublication in the Annals of Internal Medicine] Stem Cell Breakthrough Offers New Hope for Lung Disease Patients
For the first time researchers have found a type of stem cell that could prove crucial in reducing injury and scarring in the lung and even generate new lung cells. [Press release from The University of Western Australia discussing online prepublication in the American Journal of Respiratory and Critical Care Medicine] Scientists Determine Structure of Immune Molecule that Counteracts Many Strains of HIV
In findings that contribute to efforts to design an AIDS vaccine, scientists have determined the structure of an immune system antibody molecule that effectively acts against most strains of human immunodeficiency virus. [Press release from The Scripps Research Institute discussing online prepublication in the Proceedings of the National Academy of Sciences USA] Researchers Identify Key Enzyme in Melanoma Cell Development
Researchers have discovered a mechanism by which an enzyme regulates gene expression and growth in melanoma cells, a finding that could someday lead to more effective drugs to attack cancers and make them more treatable. [Press release from Virginia Commonwealth University discussing online prepublication in the Proceedings of the National Academy of Sciences USA] Stem Cell Therapy 'Damage' Seen in Kidney Disease Case
A new complication has been seen in a patient with kidney disease who received stem cell therapy, scientists have warned. [Press release from BBC News discussing online prepublication in the Journal of the American Society of Nephrology] Combined BRAF-Targeted and Immunotherapy Shows Promise for Melanoma Treatment
Combined targeted therapy against the BRAF/MAPK pathway with immunotherapy shows promise as a new therapeutic approach for the treatment of melanoma, according to results of a preclinical study. [Press release from Massachusetts General Hospital discussing online prepublication in Cancer Research] NexBio® and Weill Cornell Medical College Publish Preclinical Study Showing DAS181 (Fludase®) Anti-Influenza Drug Inhibits Parainfluenza Virus
NexBio, Inc. announced the publication of a “Major Article” in the Journal of Infectious Diseases of a preclinical study showing that treatment with DAS181 (Fludase®) inhibits infection with multiple human parainfluenza virus strains. [Press release from NexBio, Inc. discussing online prepublication in the Journal of Infectious Diseases] Specific Blood-Derived Cells Promote Survival in Heart Attack Model
A research team from McGill University report a beneficial effect on cardiac function in mouse models when implanted monocytes helped preserve cardiac function following a heart attack. [Press release from EurekAlert! discussing online prepublication in Cell Transplantation] Scientific American Article Says DNA Vaccines Are Reaching Their Potential
The article details the “rebirth” of DNA vaccines, which are recognized as safer; easier and faster to develop and manufacture; and, not requiring refrigeration — in contrast to traditional vaccines. [Press release from Inovio Pharmaceuticals, Inc. discussing online prepublication in Scientific American] Tengion Presents New Data Supporting Its Organ Regeneration Platform™
The data demonstrate that smooth muscle cells sourced from adipose tissue, which have been demonstrated to promote regeneration of tubular tissues and hollow organs, have protein and gene expression profiles distinct from those generated by mesenchymal stem cells. [Press release from Tengion, Inc. discussing research presented at the 8th Annual Meeting of the International Society for Stem Cell Research] Human Embryonic-Like Extracellular Matrix Significantly Inhibits Tumor Growth and Cancer Cell Proliferation
Studies of the human extracellular matrix produced under proprietary conditions of hypoxia and suspension have demonstrated its ability to diminish or eliminate tumor load in melanoma, breast cancer, colon cancer and glioma, both in vitro and in vivo. [Press release from Histogen, Inc. discussing research presented at the 8th Annual Meeting of the International Society for Stem Cell Research] Stem Cells From Own Eyes Restore Vision to Blind
Patients blinded in one or both eyes by chemical burns regained their vision after healthy stem cells were extracted from their eyes and reimplanted, according to a report by Italian researchers. [Press release from Bloomberg Businessweek discussing research presented at the 8th Annual Meeting of the International Society for Stem Cell Research] New Injectable Bone Material Invented for Use in Stem Cell Delivery
A team of researchers at the University of Nottingham have invented a new class of materials that can be injected by surgeons as a low-viscosity fluid into the body that, using body heat as the only trigger, converts into a tough porous material with mechanical properties that mimic human cancellous bone. [Press release from PR Newswire discussing research to be presented at the 37th Annual Meeting & Exposition of the Controlled Release Society] New Data Presented from EMBLEM™ Study for Pipeline Drug Epratuzumab for Patients Suffering from Moderate to Severe Systemic Lupus Erythematosus
UCB and Immunomedics, Inc. announced new lupus drug candidate, epratuzumab, provided a significant reduction in disease activity in patients with moderate to severe active systemic lupus erythematosus. [Press release from Immunomedics, Inc. discussing research presented at the European League Against Rheumatism Annual Meeting] Gene Therapy Reverses Type 1 Diabetes in Mice
Using gene therapy, the team from Baylor College of Medicine in Houston tried to counter the two defects that cause type 1 diabetes: autoimmune attack and destruction of the insulin-producing beta cells. [Press release from Newswise discussing research presented at The Endocrine Society’s 92nd Annual Meeting] Oxford BioMedica Announces Two-Year Phase I/II Results of ProSavin® In Parkinson's Disease
Oxford BioMedica announced new data from the ongoing Phase I/II trial of ProSavin®, its novel gene therapy for the treatment of Parkinson’s disease. [Oxford BioMedica Press Release] CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Functionally Defective Germline Variants of Sialic Acid Acetylesterase (SIAE) in Autoimmunity
Functionally defective SIAE rare and polymorphic variants represent a strong genetic link to susceptibility in relatively common human autoimmune disorders. [Nature] Quiescent Hematopoietic Stem Cells Are Activated by IFN-Gamma in Response to Chronic Infection
Findings implicate interferon-gamma (IFN-gamma) both as a regulator of hematopoietic stem cells during homeostasis and under conditions of infectious stress. [Nature] Variants Near DMRT1, TERT and ATF7IP Are Associated with Testicular Germ Cell Cancer
Researchers identified three new susceptibility loci for testicular germ cell tumor, two of which include genes that are involved in telomere regulation. [Nat Genet] Human Amnion Epithelial Cell Transplantation Abrogates Lung Fibrosis and Augments Repair
Human amnion epithelial cells offer promise as a cellular therapy for alveolar restitution and reducing lung inflammation and fibrosis. [Am J Respir Crit Care Med] Notch 1 as a Potential Therapeutic Target in Cutaneous T Cell Lymphoma
By immunohistochemistry of 40 biopsies taken from skin lesions of mycosis fungoides and Sezary syndrome researchers demonstrated prominent expression of Notch1 on tumor cells, especially in the more advanced stages. [Blood] Structure and Function of Broadly Reactive Antibody PG16 Reveal an H3 Subdomain that Mediates Potent Neutralization of HIV-1
Monoclonal antibodies PG9 and PG16 use unique structural features to mediate potent neutralization of HIV-1 that may be of utility in antibody engineering and for high-affinity recognition of a variety of therapeutic targets. [Proc Natl Acad Sci U S A] Human Polynucleotide Phosphorylase Selectively and Preferentially Degrades MicroRNA-221 in Human Melanoma Cells
Targeted overexpression of hPNPaseold-35 might provide an effective therapeutic strategy for microRNA-221–overexpressing and IFN-resistant tumors, such as melanoma. [Proc Natl Acad Sci U S A] Bmi1 Distinguishes Immature Retinal Progenitor/Stem Cells from the Main Progenitor Cell Population and is Required for Normal Retinal Development
Bmi1 distinguishes immature retinal progenitor cells (RPCs) from the main RPC population and is required for normal retinal development. [Stem Cells] Angiomyeloproliferative Lesions Following Autologous Stem Cell Therapy
This case illustrates that the development of angiomyeloproliferative lesions is a possible complication of stem cell therapy. [J Am Soc Nephrol] RNA-Based Gene Therapy for HIV with Lentiviral Vector–Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma
Researchers have demonstrated stable vector expression in human blood cells after transplantation of autologous gene-modified hematopoietic progenitor cells. [Sci Transl Med]
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