SCIENCE NEWSResearchers Use Stem Cells to Treat Children with Life-Threatening, Blistering Skin Disease Researchers have for the first time used stem cells from bone marrow to repair the skin of patients with a fatal skin disease called recessive dystrophic epidermolysis bullosa. [Press release from the University of Minnesota discussing online prepublication in the New England Journal of Medicine]Researchers Discover That One Type of Stem Cell Creates a Niche for Another Type Within Bone Marrow Researchers report that hematopoietic stem cells (HSCs) retain their unique features in response to signals from another stem cell population, mesenchymal stem cells, which create a supportive bone marrow niche for the HSCs. [Press release from Cold Spring Harbor Laboratory discussing online prepublication in Nature] Discovered Gene Causes Kabuki Syndrome Using a new, rapid and less expensive DNA sequencing strategy, scientists have discovered genetic alterations that account for most cases of Kabuki syndrome. Instead of sequencing the entire human genome, the new approach sequences just the exome. [Press release from the National Institutes of Health discussing online prepublication in Nature Genetics] Immune System Gene Linked with Parkinson's: Study A gene linked with the immune system may play a role in developing Parkinson's disease, researchers said, marking a possible advance in the search for effective treatments. [Press release from Reuters discussing online prepublication in Nature Genetics] Genetic Differences That Make Some People Susceptible to Meningitis Revealed Genetic differences that make some people susceptible to developing meningococcal meningitis and septicaemia, and others naturally immune, are revealed in a new study of over 6,000 people. [Press release from Imperial College London discussing online prepublication in Nature Genetics] More Cancer-Fighting Power — Mouse with Highly Effective Components of the Human Immune System Developed Researchers modified T cell receptors so that they would no longer ignore cancer cells, but instead specifically track and recognize them. [Press release from the Max Delbrück Center for Molecular Medicine discussing online prepublication in Nature Medicine] Human Embryonic Stem Cells and Reprogrammed Cells Virtually Identical Human embryonic stem cells and induced pluripotent stem cells exhibit very few differences in their gene expression signatures and are nearly indistinguishable in their chromatin state. [Press release from the Whitehead Institute for Biomedical Research discussing online prepublication in Cell Stem Cell] Death Dance Reveals Secrets of Apoptosis in Dissociated Human Embryonic Stem Cells Researchers have unraveled the mystery of why human embryonic stem cells and induced pluripotent stem cells undergo programmed cell death when cultured in isolation. [Press release from the RIKEN Center for Developmental Biology discussing online prepublication in Cell Stem Cell] SUMO Works with Replication Protein A Complex to Repair DNA A team of investigators has shown for the first time that the small protein SUMO can team up with the replication protein A complex to facilitate DNA repair. [Press release from the University of Texas MD Anderson Cancer Center discussing online prepublication in Molecular Cell] Merlin Protein Found to Control Liver Stem Cells, Prevent Tumor Development A research team describes finding that the protein called merlin, encoded by the NF2 (neurofibromatosis type 2) gene, controls the activity of adult stem cells that give rise to the two major types of liver cells. [Press release from EurekAlert! discussing online prepublication in Genes and Development] Scientists Map All Mammalian Gene Interactions In one of the first efforts of its kind, researchers have taken mammalian genome maps, including human maps, one step further by showing not just the order in which genes fall in the genome but which genes actually interact. [Press release from the University of California, Los Angeles discussing online prepublication in Genome Research] A Strategy to Fix a Broken Heart Engineers and physicians have built a scaffold that supports the growth and integration of stem cell-derived cardiac muscle cells. [Press release from the University of Washington discussing online prepublication in the Proceedings of the National Academy of Sciences USA] MicroRNA Molecule Increases Number of Blood Stem Cells, May Help Improve Cancer Treatment Researchers identified a tiny RNA molecule that increases the number of hematopoietic stem cells, an advance that may improve treatment of blood system cancers. [Press release from Massachusetts General Hospital discussing online prepublication in the Proceedings of the National Academy of Sciences USA] Researchers Make Major Stem Cell Discovery Using adult cells obtained from humans and the bone marrow, spleens and kidneys of mice, researchers reprogrammed the cells into a stem cell-like condition. [Press release from the Oklahoma Medical Research Foundation discussing online prepublication in Stem Cells] Scorpion Venom Improves Anti-Brain Cancer Therapy Scientists have found that an ingredient in the venom of the ‘deathstalker’ scorpion could help gene therapy become an effective treatment for brain cancer. [Press release from the Times of India discussing online prepublication in ACS Nano] Personalized Genome Sequencing in Cancer Treatment–A Major Breakthrough in Care Researchers have provided the first published example of genome-scale RNA and DNA sequencing of a tumor to aid in clinical decision making and therapeutic choice. [Press release from the B.C. Cancer Agency Genome Sciences Centre discussing online prepublication in Genome Biology] Portuguese Scientists Discover an Extraordinary New Type of White Blood Cell Researchers found a new type of white blood cell baptized NKTreg that, once activated, migrates into the liver and suppress any immune response in its vicinity. [Press release from Medical News Today discussing online prepublication in the Journal of Immunology] Scientists Use Salmonella Bug to Kill Cancer Cells Treating tumors with salmonella bacteria can induce an immune response that kills cancer cells, scientists have found — a discovery that may help them create tumor-killing immune cells to inject into patients. [Press release from Reuters discussing online prepublication in Science Translational Medicine] Taiwanese Researchers Find Breakthrough in Stem Cell Study Scientists at the National Health Research Institutes announced a breakthrough in stem cell research through experiments that successfully turn cells in the umbilical vein into “all-purpose” induced pluripotent stem cells. [The China Post] CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Bone Marrow Transplantation for Recessive Dystrophic Epidermolysis Bullosa Increased type VII collagen deposition and a sustained presence of donor cells were found in the skin of children with recessive dystrophic epidermolysis bullosa after allogeneic bone marrow transplantation. [N Engl J Med] Production of p53 Gene Knockout Rats by Homologous Recombination in Embryonic Stem Cells Researchers report the generation of gene knockout rats using the embryonic stem cell-based gene targeting technology. [Nature] Mesenchymal and Hematopoietic Stem Cells Form a Unique Bone Marrow Niche Results uncover an unprecedented partnership between two distinct somatic stem-cell types and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs. [Nature] Exome Sequencing Identifies MLL2 Mutations as a Cause of Kabuki Syndrome Researchers demonstrate the successful application of exome sequencing to discover a gene for an autosomal dominant disorder, Kabuki syndrome. [Nat Genet] Common Genetic Variation in the HLA Region is Associated with Late-Onset Sporadic Parkinson's Disease The genetic association with HLA supports the involvement of the immune system in Parkinson's disease and offers new targets for drug development. [Nat Genet] Genome-Wide Association Study Identifies Variants in the CFH Region Associated with Host Susceptibility to Meningococcal Disease The study suggests that host genetic variation in the regulators of complement activation plays a role in determining the occurrence of invasive disease versus asymptomatic colonization by this pathogen. [Nat Genet] Transgenic Mice with a Diverse Human T Cell Antigen Receptor Repertoire Researchers generated transgenic mice with the entire human TCR(alpha)(beta) gene loci (1.1 and 0.7 Mb), whose T cells express a diverse human T cell receptor (TCR) repertoire that compensates for mouse TCR deficiency. [Nat Med] Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells Genome-wide maps of nucleosomes with histone H3K4me3 and H3K27me3 modifications indicate that there is little difference between embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) with respect to these marks. Gene expression profiles confirm that the transcriptional programs of ESCs and iPSCs show very few consistent differences. [Cell Stem Cell] Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells Researchers show that the apoptosis of human embryonic stem cells, which is of a nonanoikis type, is caused by ROCK-dependent hyperactivation of actomyosin and efficiently suppressed by the myosin inhibitor Blebbistatin. [Cell Stem Cell] Regulation of DNA Repair through DeSUMOylation and SUMOylation of Replication Protein A Complex Results demonstrate that SUMOylation status of the 70 kDa subunit of replication protein A complex plays a critical role in the regulation of DNA repair through homologous recombination. [Mol Cell] Nf2/Merlin Controls Progenitor Homeostasis and Tumorigenesis in the Liver Researchers report that liver-specific deletion of the neurofibromatosis type 2 (Nf2) tumor suppressor gene in the developing or adult mouse specifically yields a dramatic, progressive expansion of progenitor cells throughout the liver without affecting differentiated hepatocytes. [Genes Dev]
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