TOP STORY Researcher Discovers Key Mechanism for Transforming Adult Cells Researchers have discovered that so-called “grim-reaper” caspase genes are the gatekeepers that can open the door to allow differentiated adult cells to regress to undifferentiated induced pluripotent stem cells. [Press release from the University of Colorado Denver discussing online prepublication in Cell Stem Cell]
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| SCIENCE NEWSStem Cell Model for Long-QT Syndrome May Spark New Avenues for Heart Research Pluripotent stem cells, derived from skin fibroblasts of two relatives with familial long-QT syndrome and induced to differentiate into cardiac myocytes, exhibited the electrophysiologic traits of the disorder, showing for the first time that stem cell models “can recapitulate aspects of genetic cardiac diseases.” [Press release from Internal Medicine News discussing online prepublication in the New England Journal of Medicine]Team Finds Protein That Sets the Stage for Exchanges of DNA Code in Eggs and Sperm Scientists have discovered a regulatory protein that influences where genetic material gets swapped between maternal and paternal chromosomes during the process of creating eggs and sperm. [Press release from the University of Pittsburgh discussing online prepublication in Nature] Stem Cells Repair Damaged Spinal Cord Tissue Researchers have shown how stem cells, together with other cells, repair damaged tissue in the mouse spinal cord. [Press release from the Karolinska Institutet discussing online prepublication in Cell Stem Cell] Research Team Developed New Stem Cell Therapy for Heart Repair A research team has proved that by combining self-assembling peptide nanofiber hydrogel with autologous bone marrow stem cells, myocardial protection after acute myocardial infarction, vascular regeneration and heart functions can be improved. [Press release from National Cheng Kung University discussing online prepublication in Circulation] Shifting Forms: Study Shows How Variations of Same Protein Affect Immune Response Researchers have identified the steps that control how different forms of an immune cell protein called CD45 are controlled in the arc of a body’s immune response. [Press release from the University of Pennsylvania School of Medicine discussing online prepublication in Molecular Cell] Researcher Makes Breakthrough Discovery to Curb Heart Failure A researcher has announced a breakthrough discovery to block a protein that can contribute to heart failure. They have discovered a novel method, using gene therapy, to block the actions of a gene-encoded protein. [Press release from Nova Southeastern University discussing online prepublication in the Journal of the American College of Cardiology] Gene Identified That Prevents Stem Cells from Turning Cancerous New research shows that having too many stem cells, or stem cells that live for too long, can increase the odds of developing cancer. By identifying a mechanism that regulates programmed cell death in precursor cells for hematopoietic stem cells, the work is the first to connect the death of such cells to a later susceptibility to tumors in mice. [Press release from Rockefeller University discussing online prepublication in Genes and Development] Research Shows a Promising New Method to Reduce Graft-Versus-Host-Disease After Bone Marrow Transplantation Researchers have discovered a new method to prevent the immune-system attacks that often occur following bone marrow transplants. [Press release from the University of Michigan discussing online prepublication in Blood] Holding on to Cells with DNA Researchers designed pieces of DNA that self-assemble into thick long strands four double helices across that structurally resemble the protein fibers of the natural extracellular matrix. [Press release from ScienceBlogs discussing online prepublication in the Journal of the American Chemical Society] Mice with Human Body’s Defences Scientists, with the help of human stem cells, generated mice with a human immune system, which were then vaccinated to produce human monoclonal antibodies. [Press release from the Helmholtz Centre for Infection Research discussing online prepublication in PLoS ONE] Better Drug Delivery Eradicates Tumors A new study demonstrates further promise for chitosan/interleukin-12 as an effective anti-tumor immunotherapy. Findings revealed that injections of chitosan/IL-12 eradicated aggressive colorectal and pancreatic tumors, as well as superficial bladder cancer. [Press release from the University of Arkansas discussing online prepublication in the Journal of Immunotherapy] CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome Researchers generated patient-specific pluripotent stem cells from members of a family affected by long-QT syndrome type 1 and induced them to differentiate into functional cardiac myocytes. The patient-derived cells recapitulated the electrophysiological features of the disorder. [N Engl J Med] xnd-1 Regulates the Global Recombination Landscape in Caenorhabditis elegans Researchers show that xnd-1 functions independently of genes required for X chromosome-specific gene silencing, revealing a novel pathway that distinguishes the X from autosomes in the germ line, and further show that xnd-1 exerts its effects on meiotic crossovers, at least in part, by modulating levels of H2A lysine 5 acetylation. [Nature] Apoptotic Caspases Regulate Induction of iPSCs from Human Fibroblasts Researchers report that caspases 3 and 8, two proteases associated with apoptotic cell death, play critical roles in induction of induced pluripotent stem cells (iPSCs) from human fibroblasts. [Cell Stem Cell] Origin of New Glial Cells in Intact and Injured Adult Spinal Cord Several distinct cell types in the adult central nervous system have been suggested to act as stem or progenitor cells generating new cells under physiological or pathological conditions. Researchers have assessed the origin of new cells in the adult mouse spinal cord by genetic fate mapping. [Cell Stem Cell] Intramyocardial Peptide Nanofiber Injection Improves Postinfarction Ventricular Remodeling and Efficacy of Bone Marrow Cell Therapy in Pigs Researchers demonstrated that nanofiber (NF) injection alone prevents ventricular remodeling, whereas cell implantation with NFs improves cell retention and cardiac functions after myocardial infarction in pigs. [Circulation] Phosphorylation-Dependent Regulation of PSF by GSK3 Controls CD45 Alternative Splicing Data place two players, GSK3 and TRAP150, in the complex network that regulates CD45 alternative splicing and demonstrate a paradigm for signal transduction from the cell surface to the RNA processing machinery through the multifunctional protein PSF. [Mol Cell] Sept4/ARTS Is Required for Stem Cell Apoptosis and Tumor Suppression Researchers show that deletion of the mouse Sept4 gene, which encodes the Inhibitor of Apoptosis Protein antagonist ARTS, promotes tumor development. [Genes Dev] Notch Signaling Is a Critical Regulator of Allogeneic CD4+ T Cell Responses Mediating Graft-Versus-Host Disease Results identify Notch as a novel essential regulator of pathogenic CD4+ T cell responses during acute graft-versus-host disease and suggest that Notch signaling in T cells should be investigated as a therapeutic target following allogeneic hematopoietic stem cell transplantation. [Blood] A Structurally Tunable DNA-Based Extracellular Matrix The principles of DNA nanotechnology and protein engineering have been combined to generate a new class of artificial extracellular matrices. The potential of this material for ex vivo cellular scaffolding was demonstrated using experiments in which human cervical cancer cells were found to adhere strongly, stay alive, and grow with high migration rates. [J Am Chem Soc] Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice Researchers describe a novel approach to generate fully human monoclonal antibodies by combining a humanized mouse model with a new B cell immortalization technique. [PLoS ONE]
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| POLICYEuropean Medicines Agency Strengthens Rules on Conflicts of Interests of Its Scientific Experts The European Medicines Agency has published new rules on how the Agency will be handling potential conflicts of interests of its scientific experts, following endorsement by its Management Board. [European Medicines Agency, European Union] IQWiG: Law Must Prescribe Obligation to Publish All Clinical Trials If the currently discussed draft on the “Law on the Reorganization of the Pharmaceutical Market” (AMNOG) is implemented, drug manufacturers will in future have to register their clinical trials at inception and publish results after completion. [Institute for Quality and Efficiency in Health Care (IQWiG), Germany] Loss of UK Genetics Public Bodies Confirmed The official announcement from the UK Government on the future of non-departmental public bodies has confirmed the rumored abolition of a total of 192 public bodies, with a further 118 to be merged. [Foundation for Genomics and Population Health, United Kingdom] More Legal Jousting in Stem Cell Case The two sides in the ongoing court battle over stem cell research filed another batch of legal documents in response to court-ordered deadlines [Court of Appeals, United States] HHS to Let Secretary's Genetics Committee Expire The Secretary's Advisory Committee on Genetics, Health, and Society will disband next month, eight years after its founding. The committee had completed its original task, advising the Department of Health and Human Services (HHS) on a number of issues related to genomics. [Department of Health and Human Services, Untied States] Advisory Council on Blood Stem Cell Transplantation; Notice of Meeting (FR Doc. 2010-25646) [Department of Health and Human Services, United States] Screening Framework Guidance for Providers of Synthetic Double-Stranded DNA (FR Doc. 2010-25728) [Department of Health and Human Services, United States] Proposed Collection; Comment Request; National Evaluation of the Clinical and Translational Science Awards (CTSA) Initiative (FR Doc. 2010-25589) [Department of Health and Human Services, United States] Agency Information Collection Request. 30-Day Public Comment Request (FR Doc. 2010-25587) [Department of Health and Human Services, United States] Partnerships To Advance the National Occupational Research Agenda (NORA) (FR Doc. 2010-25973) [Centers for Disease Control and Prevention, States]
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| BUSINESSCell Cure Neurosciences Ltd., a Subsidiary of BioTime, Inc. and Hadasit Bio Holdings Ltd., Enters into an Exclusive License Option Agreement with Teva Pharmaceutical Industries Ltd. to Develop and Market OpRegen™ for the Treatment of Age-Related Macular Degeneration BioTime, Inc., Cell Cure Neurosciences Ltd., and Hadasit Bio-Holdings Ltd. jointly announced that Cell Cure and Teva Pharmaceutical Industries Ltd. have entered into an exclusive license option agreement to develop and commercialize Cell Cure's OpRegen™ product for the treatment of age-related macular degeneration. OpRegen™ is a proprietary formulation of embryonic stem cell-derived retinal pigment epithelial cells designed by Cell Cure. [BioTime, Inc. Press Release] Breakthrough Regenerative Therapy for Newborns with Metabolic Disorders in Qatar Hamad Medical Corporation has partnered with the University Children’s Hospital in Heidelberg and German biotech company Cytonet GmbH & Co. KG to establish an agreement to conduct the clinical trial SELICA (Safety and Efficacy of Liver Cell Application). [Hamad Medical Corporation Press Release] BioFocus Extends Collaboration with Chiesi BioFocus, a leading provider of integrated gene-to-clinical candidate drug discovery services, announced that it has expanded a collaboration with Chiesi Farmaceutici, a privately held Italian pharmaceutical company. [BioFocus Press Release] KINAXO Enters Agreement with Bristol-Myers Squibb Company KINAXO Biotechnologies GmbH announced that Bristol-Myers Squibb Company has chosen KINAXO to support several of its drug discovery programs. [KINAXO Biotechnologies GmbH Press Release] ImmunoGen, Inc. Announces Collaboration for Rights to Use ImmunoGen's Targeted Antibody Payload Technology ImmunoGen, Inc. announced that it has entered into a collaboration agreement with Novartis to discover and develop targeted anticancer therapeutics using antibodies to several antigen targets to be named by Novartis. [ImmunoGen, Inc. Press Release] Genmab Announces Antibody Development Collaboration with Lundbeck Genmab A/S announced an agreement to create and develop human antibody therapeutics for disorders of the central nervous system with H. Lundbeck A/S. [Genmab Press Release] American Cancer Society Awards New Research and Training Grants The American Cancer Society has awarded 94 national research and training grants totaling $46,633,000 to 70 institutions nationwide in the first of two grants cycles for 2011. [American Cancer Society Press Release] Cytomedix Secures $13 Million in Committed Funding Cytomedix, Inc., a leading developer of biologically active regenerative therapies for wound care, inflammation and angiogenesis, announced that the Company has secured approximately $13 million in current and future funding via a registered direct offering and commitments under two separate equity purchase agreements. [Cytomedix, Inc. Press Release] Tekmira and Collaborators Awarded $2.4 Million NIH Grant for Development of RNAi Therapeutics to Treat Ebola and Marburg Viral Infections Tekmira Pharmaceuticals Corporation announced that, together with collaborators at The University of Texas Medical Branch, it has been awarded a new United States National Institutes of Health (NIH) grant to support research to develop RNAi therapeutics to treat Ebola and Marburg hemorrhagic fever viral infections using Tekmira’s lipid nanoparticle delivery technology. [Tekmira Pharmaceuticals Corporation Press Release] Geron Initiates Clinical Trial of Human Embryonic Stem Cell-Based Therapy Geron Corporation announced the enrollment of the first patient in the company's clinical trial of human embryonic stem cell-derived oligodendrocyte progenitor cells, GRNOPC1. [Geron Corporation Press Release] BrainStorm Receives Approval to Begin Clinical Trial of Adult Stem Cell Therapy in Patients with ALS BrainStorm Cell Therapeutics Inc. announced that the Israeli Ministry of Health has granted clearance for a Phase I/II clinical trial using the company’s autologous NurOwn™ stem cell therapy in patients with amyotrophic lateral sclerosis (ALS). [BrainStorm Cell Therapeutics Inc. Press Release] CEL-SCI Corporation Receives Approval from First Taiwanese Institutional Review Board to Commence Phase III Clinical Trial of Multikine in Head and Neck Cancer CEL-SCI Corporation announced it has received approval from the first Taiwanese Institutional Review Board to begin enrollment of subjects for a Phase III clinical trial of Multikine®, the Company's flagship immunotherapy developed as a first-line standard of care in treating head and neck cancer. [CEL-SCI Corporation Press Release] Immunomedics Awarded Additional U.S. Patent for Antibody Therapy of Autoimmune Diseases Immunomedics, Inc. announced that additional claims for the patent family “Method and kit for imaging and treating organs and tissue,” were issued as U.S. Patent No. 7,811,570. [Immunomedics, Inc. Press Release] The New York Stem Cell Foundation Announces 2010 NYSCF-Investigators in Conjunction with Fifth Annual Translational Stem Cell Conference In an expansion of its ongoing effort to promote the next generation of stem cell scientists, The New York Stem Cell Foundation (NYSCF) named the first six NYSCF Investigators. Each of the NYSCF-Robertson and NYSCF-Helmsley Investigators will receive up to $1.5 million over the next five years to expand their own laboratories, train other scientists and foster innovative high-risk/high reward research to explore the therapeutic potential of stem cells derived from humans and model organisms. [The New York Stem Cell Foundation Press Release] Personal Genetic Secrets Made Public by Experts The Genomes Unzipped project is releasing personal genetic data from contributors — researchers and other genomics experts and commentators, who have had their genome scanned by personal genomics companies. [Foundation for Genomics and Population Health Press Release]
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EVENTS (Listed by Date)
6th Modern Drug Discovery & Development Summit (M3D) October 20-22, 2010 San Francisco, United StatesNEW Cancer Immunotherapy: A Long-Awaited Reality October 21, 2010 New York, United States NEW International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference October 22-24, 2010 Dallas, United States European Society of Gene and Cell Therapy (ESGCT) 18th Annual Congress October 22-25, 2010 Milan, Italy 3rd Annual Dubai Congress on Anti-Aging and Aesthetic Medicine (DCAAAM) October 26-27, 2010 Dubai, United Arab Emirates International Consensus Conference: Risk-Based Decision Making for Blood Safety October 26-28, 2010 Toronto, Canada 2nd Annual Stem Cells Asia and Regenerative Medicine Congress October 26-28, 2010 Seoul, Korea Select Biosciences 2nd Annual Lab-on-a-Chip World Congress October 28-29, 2010 San Diego, United States Select Biosciences 3rd Annual Molecular Diagnostics World Congress October 28-29, 2010 San Diego, United States Fraunhofer Life Science Symposium Leipzig 2010 October 29-30, 2010 Leipzig, Germany FDA Public Workshop on Cell and Gene Therapy Clinical Trials in Pediatric Populations November 2, 2010 North Bethesda, United States NEW 5th UK Cancer Stem Cell Symposium November 2, 2010 London, United Kingdom BioMalaysia 2010 November 2-3, 2010 Kuala Lumpur, Malaysia Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy November 2-3, 2010 Singapore NEW 2010 National GvHD Symposium November 4, 2010 Cleveland, United States World Cord Blood Congress November 4-7, 2010 Marseille, France 9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research November 7-10, 2010 Philadelphia, United States NEW Cambridge Healthtech Institute's Inaugural Stem Cells in Drug Discovery and Development November 8-9, 2010 San Diego, United States NEW GTCbio 8th Annual Vaccines: “All Things Considered” Conference November 8-9, 2010 Washington, DC, United States 5th Annual European Biomarkers Summit November 9-10, 2010 Florence, Italy Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC) November 12-13, 2010 Tianjin, China Select Biosciences 2nd Annual RNAi Asia Conference and Exhibition November 15-16, 2010 Singapore The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms November 15-18, 2010 Nara, Japan 3rd Annual Workshop on Genome Engineering November 16, 2010 Seattle, United States NEW 22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics November 16-19, 2010 Berlin, Germany 9th Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases November 17-19, 2010 Sonoma, United States 8th Annual Commercial Translation of Regenerative Medicine Conference November 18-19, 2010 London, United Kingdom NEW Translational Excellence in Regenerative Medicine (TeRM) – Biophysical Stimuli and Mass Transport for Tissue Development November 18-19, 2010 Lattrop, The Netherlands 4th Annual Conference of the Korea Society of Gene Therapy (KSGT) November 19, 2010 Seoul, Korea Stem Cell Network's 10th Annual Scientific Meeting November 22-24, 2010 Calgary, Alberta HealthTech and Medicines Knowledge Transfer Network 7th Annual BioProcessUK Conference November 24-25, 2010 Manchester, United Kingdom NEW Tumor Immunology: Basic and Clinical Advances November 30-December 3, 2010 Miami, United Sates 2ND European Association for Cardio-Thoracic Surgery (EACTS) Meeting on Cardiac and Pulmonary Regeneration December 3-4, 2010 Vienna, Austria 3rd Annual BioPartnering China December 5-7, 2010 Shanghai, China Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference December 5-8, 2010 Orlando, United States 5th Annual Stem Cell Meeting on the Mesa December 7, 2010 La Jolla, United States Genesis 2010 December 9, 2010 London, United Kingdom The American Society for Cell Biology 50th Annual Meeting December 11-15, 2010 Philadelphia, United States Functional Consequences of Structural Variation in the Genome January 8-13, 2011 Steamboat Springs, Colorado NEW Nano in Cancer: Linking Chemistry, Biology, and Clinical Applications In Vivo January 12-15, 2011 Miami, United Sates COGEM Symposium: GM Viruses as Medicine: Panacea or Pandora's Box? January 20, 2011 Amsterdam, The Netherlands NEW Extracellular Matrix and Cardiovascular Remodeling January 23-28, 2011 Tahoe City, United States 5th Annual Stem Cells and Regenerative Medicine World Congress January 24-25, 2011 San Diego, United States BIO Asia International Partnering Conference January 24-25, 2011 Tokyo, Japan Phacilitate 7th Annual Cell & Gene Therapy Forum 2011 January 24-26, 2011 Washington, DC, United States Phacilitate 9th Annual North American Vaccine Forum January 24-26, 2011 Washington, DC, United States Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease January 30-February 4, 2011 Santa Fe, United States NEW CMC Workshop: Translating Science into Successful Regulatory Submissions February 7-9, 2011 Washington, DC, United States NEW 23rd Lorne Cancer Conference February 10-12, 2011 Lorne, Australia NEW BMT Tandem Meetings (ASBMT/CIBMTR) February 17-21, 2011 Honolulu, Hawaii NEW 18th International Molecular Medicine Tri-Conference (MMTC) February 23-25, 2011 San Francisco, United States NEW Molecular Medicine Tri-Conference: Stem Cells – Revolutionizing Regenerative Medicine and Personalized Therapy 2011 February 23-25, 2011 San Francisco, United States NEW Molecular Medicine Tri-Conference: Inaugural Circulating Tumor Cells for Cancer Detection, Diagnosis, Prognosis and Treatment February 23-25, 2011 San Francisco, United States NEW Targeting PI3K/mTOR Signaling in Cancer February 24-27, 2011 San Francisco, United Sates NEW 9th Annual BioPartnering North America February 27-March 1, 2011 Vancouver, Canada NEW 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011) February 27-March 2, 2011 Boston, United States NEW American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer March 3-6, 2011 Vancouver, Canada NEW Stem Cells, Cancer and Metastasis (C4) March 6-11, 2011 Dillon, United States NEW Spring Meeting of the Dutch Society of Gene Therapy (NVGT) March 10-11, 2010 Heeze, The Netherlands NEW BIO-Europe Spring 2011 March 14-16, 2011 Milan, Italy NEW The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics March 16-19, 2011 Las Vegas, United States NEW HIV Evolution, Genomics and Pathogenesis March 20-25, 2011 Whistler, British Columbia Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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