SCIENCE NEWSPatient-Derived Stem Cells Could Help Test Cardiac Disease Treatments Scientists turned skin cells into induced pluripotent stem cells, then coaxed these stem cells to become cardiac cells. The newborn heart cells showed an abnormal electrical activity in the laboratory, recapitulating clinical presentation of the long QT syndrome patient, making them useful for studying this potentially lethal disorder. [Press release from the American Technion Society discussing online prepublication in Nature] Scientists Uncover Inherent Properties of Cell Signaling Pathways Using an innovative approach based on synthetic biology and mathematical modeling, researchers have explored the workings of a crucial cell-signaling pathway, the mitogen-activated protein kinase cascade. [Press release from the University of Pennsylvania discussing online prepublication in Cell]Overexpression of Repetitive DNA Sequences Discovered in Common Tumor Cells Researchers have discovered a previously unknown feature of common tumor cells — massive overexpression of certain DNA sequences that do not code for proteins. These DNA sequences — called satellite repeats — have been studied for their role in chromosomal structure but previously were not suspected of having a role in cancer. [Press release from Massachusetts General Hospital discussing online prepublication in Science] Scientists Find the “Master Switch” for Key Immune Cells in Inflammatory Diseases Scientists have identified a protein that acts as a “master switch” in certain white blood cells, determining whether they promote or inhibit inflammation. [Press release from Imperial College London discussing online prepublication in Nature Immunology] Researchers Gain Better Understanding of Interaction of Human Immune System with HIV Scientists announced discoveries that are relevant to better understanding of the interaction of the human immune system with HIV and which could potentially guide the development of effective immunization protocols. [Press release from the Seattle Biomedical Research Institute discussing online prepublication in PLoS Pathogens] Embryonic Stem Cells Are a Potentially Unlimited Source of Functional Platelets for Transfusion Advanced Cell Technology, Inc. reported that its hemangioblast-based technology can be used to generate functional platelets from human embryonic stem cells (hESCs). This research shows that it is feasible to generate functional megakaryocytes and platelets from hESCs on a large scale. [Press release from Stem Cell & Regenerative Medicine International, Inc. discussing online prepublication in Cell Research] Syndax Announces Publication of Entinostat NSCLC Data Syndax, a clinical-stage epigenetics oncology company, announced publication of data of entinostat combined with the demethylating agent Vidaza® (azacitidine) showing effect in reducing tumor burden in differentiated tumor cells in animal tumor models of non-small cell lung cancer (NSCLC). [Press release from Syndax Pharmaceuticals, Inc. discussing online prepublication in Cancer Research] Nanodisk Gene Therapy A team of scientists demonstrated that the peptide R9, formed by a specific type of amino-acid (arginine), can encapsulate genetic material, assemble itself with other identical molecules to form nanoparticles and enter directly into the cell nucleus to release the material it contains. The nanoparticles have the shape of a disk, with a diameter measuring 20 nanometers and a height of 3 nm. [Press release from EurekAlert! discussing online prepublication in Biomaterials] Better Way to Treat Deadly Brain Tumors? Lab studies show that combining drugs that target a variety of developmental cell signaling pathways may do a better job of killing deadly brain tumors than single drugs that target one pathway at a time. [Press release from Johns Hopkins Medicine discussing online prepublication in Clinical Cancer Research] Blame the “Chaperone”: Researchers Find Mutation in “Chaperone” Proteins That Lead to Major Developmental Abnormalities A research team has identified a mutation in a gene that is essential for correct protein-processing in cells. Defects in protein folding are associated with a variety of abnormalities and diseases. [Press release from The Jackson Laboratory discussing online prepublication in the Journal of Biological Chemistry] Researchers Find Critical Link Between Down Syndrome and Alzheimer’s Disease Researchers have discovered that the genetic mechanism which destroys brain cells is responsible for early development of Alzheimer’s Disease in people with Down Syndrome and for development of Alzheimer’s Disease in general population — providing a potential new target for drugs that could forestall dementia in people with either condition. [Press release from the University of British Columbia discussing online prepublication in the Journal of Biological Chemistry] Success in Treating End-Stage Liver Disease Transplanting autologous bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients, report researchers. Yet, the mechanism by which the infusion of CD34+ stem cells improves liver function remains elusive. [Press release from EurekAlert! discussing online prepublication in Cell Transplantation] Scientists Construct Synthetic Proteins That Sustain Life In a groundbreaking achievement that could help scientists “build” new biological systems, scientists have constructed for the first time artificial proteins that enable the growth of living cells. [Press release from Princeton University discussing online prepublication in PLoS One] Biomedical Breakthrough: Discovery Addresses Key Roadblock to Growing Replacement Tissues, Organs Researchers from Baylor College of Medicine and Rice University have broken one of the major roadblocks on the path to growing transplantable tissue in the lab: they've found a way to grow the blood vessels and capillaries needed to keep tissues alive. [Press release from Baylor College of Medicine discussing online prepublication in Acta Biomaterialia] Inovio Pharmaceuticals' Novel DNA Vaccine for Clade C HIV Achieves Immune Responses and Protection in Non-Human Primates Inovio Pharmaceuticals, Inc. announced the publication of a scientific paper highlighting positive preclinical results from Inovio's novel DNA vaccine targeting HIV Clade C viruses. [Press release from Inovio Pharmaceuticals, Inc. discussing online prepublication in Vaccine] RevaTen Platelet-Rich Plasma Shows Promise as Potential Treatment for Heart Attacks Researchers at the Stanford University School of Medicine, in collaboration with BioParadox, Inc., have published data supporting the use of platelet-rich plasma as a promising biologic treatment for myocardial infarction. [Press release from EurekAlert! discussing online prepublication in Cardiovascular Revascularization Medicine] Scientists Bring New Hopes to Translate Human Stem Cell Technologies to the Clinic Scientists have successfully generated new human induced pluripotent stem cells (hiPSCs) that are free from animal products. [University of Hong Kong Press Release] CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
Modeling the Long QT Syndrome with Induced Pluripotent Stem Cells Researchers report the development of a patient/disease-specific human induced pluripotent stem cell (iPSC) line from a patient with type-2 long QT syndrome (which is due to the A614V missense mutation in the KCNH2 gene). The generated iPSCs were coaxed to differentiate into the cardiac lineage. [Nature] Tunable Signal Processing in Synthetic MAP Kinase Cascades This work demonstrates that tunable signal processing is inherent to minimal MAPK modules and elucidates principles for rational design of synthetic signaling systems. [Cell] Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers The overexpression of satellite transcripts in cancer may reflect global alterations in heterochromatin silencing and could potentially be useful as a biomarker for cancer detection. [Science] IRF5 Promotes Inflammatory Macrophage Polarization and TH1-TH17 Responses Researchers show that IRF5 expression in macrophages was reversibly induced by inflammatory stimuli and contributed to the plasticity of macrophage polarization. [Nat Immunol] Using Mechanobiological Mimicry of Red Blood Cells to Extend Circulation Times of Hydrogel Microparticles Researchers synthesized hydrogel microparticles with tunable elasticity in the physiological range, which resemble red blood cells in size and shape, and tested their behavior in vivo. [Proc Natl Acad Sci U S A] Platelets Generated from Human Embryonic Stem Cells Are Functional In Vitro and in the Microcirculation of Living Mice Researchers report that it is feasible to generate functional megakaryocytes and platelets from human embryonic stem cells on a large scale. [Cell Res] Combination Therapy with Vidaza and Entinostat Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotopic Lung Cancer Model Findings show the promise for epigenetic therapy in cancer management and provide an orthotopic lung cancer model that can assess therapeutic efficacy and reprogramming of the epigenome in tumors harboring different genetic and epigenetic profiles to guide use of these drugs. [Cancer Res] Internalization and Kinetics of Nuclear Migration of Protein-Only, Arginine-Rich Nanoparticles Researchers have investigated the uptake and kinetics of intracellular migration of protein nanoparticles built up by a chimerical multifunctional protein, and functionalized by a pleiotropic, membrane-active terminal peptide. [Biomaterials] Autologous Hematopoietic Stem Cell Transplantation in 48 Patients with End-Stage Chronic Liver Diseases Results suggest that autologous CD34+ stem cell transplantation may be safely administered and appears to offer some therapeutic benefit to patients with both viral and autoimmune-induced end-stage liver disease. [Cell Transplant] De Novo Designed Proteins from a Library of Artificial Sequences Function in Escherichia Coli and Enable Cell Growth A central challenge of synthetic biology is to enable the growth of living systems using parts that are not derived from nature, but designed and synthesized in the laboratory. As an initial step toward achieving this goal, researchers probed the ability of a collection of >106 de novo designed proteins to provide biological functions necessary to sustain cell growth [PLoS One] Covalently Immobilized Platelet-Derived Growth Factor-BB Promotes Angiogenesis in Biomimetic Poly(Ethylene Glycol) Hydrogels In this work bioactive, covalently immobilized platelet-derived growth factor BB was shown to induce tubulogenesis on two-dimensional modified surfaces, migration in three-dimensional degradable hydrogels and angiogenesis in a mouse cornea micropocket angiogenesis assay. [Acta Biomater]
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