Scientists Discover Cause of Rare Skin Cancer That Heals Itself
Scientists have discovered the gene behind a rare skin cancer which grows rapidly for a few weeks before healing spontaneously. [Press release from the University of Dundee discussing online prepublication in Nature Genetics]New Nanoparticles Could Lead to Powerful Vaccines for HIV and Other Diseases
Engineers have designed a new type of nanoparticle that could safely and effectively deliver vaccines for diseases such as HIV and malaria. [Press release from Massachusetts Institute of Technology discussing online prepublication in Nature Materials]
Hot Off the Presses, New Skin for Burn Victims
Designing organs on a computer and printing them out in a matter of minutes definitely beats growing them in vats. But is it possible? Scientists say the technology is closer then you might think, and could revolutionize transplantation and wound repair. [Press release from ScienceNOW discussing research presented at the Annual Meeting of the American Association for the Advancement of Science]
Scientists Tie Cell Cycle “Clock” to Childhood Cancers
Abnormal chromosomes have long been detected in children with leukemias and lymphomas, and now, research has linked such abnormalities with a molecular clock that controls the timing of a high-stakes genetic exchange inside dividing immune system cells. [Press release from Johns Hopkins University discussing online prepublication in Immunity]
Cancer-Related Pathways Reveal Potential Treatment Target for Congenital Heart Disease
Cross-disciplinary teams of scientists studying genetic pathways that are mutated in many forms of cancer, but which also cause certain forms of congenital heart disease — including hypertrophic cardiomyopathy (HCM) — have introduced these mutations into mice and successfully treated HCM in the lab. [Press release from EurekAlert! discussing online prepublication in the Journal of Clinical Investigation]
Study Identifies Genes Associated with Binge Drinking
Scientists found that manipulating two receptors in the brain, GABA receptors and toll-like receptor 4, “caused profound reduction” of binge drinking for two weeks in rodents that had been bred and trained to drink excessively. [Press release from the University of Maryland School of Medicine discussing online prepublication in the Proceedings of the National Academy of Sciences USA]
Personalized Medicine Comes Within Reach
A team of scientists has established a strategy for identifying biomarkers. If a particular pattern of these biomarkers can be detected in the blood, this indicates a cancerous disease. [Press release from Swiss Federal Institute of Technology Zurich discussing online prepublication in the Proceedings of the National Academy of Sciences USA]
Scientists Devise Artificial Intestine to Help Engineer Disease-Fighting Gut Bacteria
3D hydrogel scaffolds developed by researchers will allow scientists to grow cells under realistic physiological conditions. [Press release from Cornell University discussing online prepublication in Lab on a Chip]
Vaccine Made with Synthetic Gene Protects Against Deadly Pneumonia
Researchers have developed an experimental vaccine that appears to protect against an increasingly common and particularly deadly form of pneumococcal pneumonia. [Press release from Albert Einstein College of Medicine of Yeshiva University discussing online prepublication in the Journal of Infectious Diseases]
Human Umbilical Cord Blood Cells Aid Diabetic Wound Healing
Transplanting human umbilical cord blood-derived endothelial progenitor cells has been found to “significantly accelerate” wound closure in diabetic mouse models, said a team of Korean researchers. [Press release from EurekAlert! discussing online prepublication in Cell Transplantation]
Gene Fuelled Transporter Causes Breast Cancer Cells to Self-Destruct
Scientists have shown that they can deliver a gene directly into breast cancer cells causing them to self-destruct, using an innovative, miniscule gene transport system. [Press release from Queen’s University Belfast discussing online prepublication in the International Journal of Pharmaceutics]
Designing New Molecular Tools to Study the Life and Death of a Cancer Cell
Researchers have developed new synthetic molecules as models to study the structural and functional role of the proline residue and tetrapeptide sequence important for the regulation of cancer cell apoptosis by the XIAP protein. [Press release from ScienceDaily discussing online prepublication in Experimental Biology and Medicine]
Researchers First Worldwide to Generate Pluripotent Stem Cells from Horses
In a world first, pluripotent stem cells have been generated from horses. The findings will help enable new stem cell based regenerative therapies in veterinary medicine, and because horses’ muscle and tendon systems are similar to our own, aid the development of preclinical models leading to human applications. [Press release from the University of Montreal discussing online prepublication in Stem Cell Reviews and Reports]
BrainStorm’s NurOwn™ Stem Cell Technology Shows Promise for Treating Sciatic Nerve Injury
BrainStorm Cell Therapeutics Inc. announced that intramuscular transplantation of autologous, astrocyte-like cells that produce and secrete neurotrophic factors, representing the company’s NurOwn™ technology platform, preserved motor function, significantly inhibited the degeneration of the neuromuscular junctions, and preserved the myelinated motor axons in an animal sciatic nerve injury model. [Press release from BrainStorm Cell Therapeutics Inc. discussing online prepublication in Stem Cell Reviews and Reports]
Clinical Responses Demonstrated in Metastatic Castrate Resistant Prostate Cancer Patients Treated with BPX-101 Cancer Vaccine
Bellicum Pharmaceuticals, Inc. announced the presentation of Phase I/II safety and efficacy data for BPX-101, a novel drug-activated dendritic cell vaccine for metastatic castrate resistant prostate cancer. [Press release from Bellicum Pharmaceuticals, Inc. discussing research presented at the 2011 Genitourinary Cancers Symposium]
Sangamo BioSciences Announces Presentation of Positive Clinical Data from Novel ZFN Therapeutic Approach for HIV/AIDS Treatment
Sangamo BioSciences, Inc. announced the presentation of positive preliminary clinical data from its Phase I trial (SB-728-902). The study is designed to evaluate safety and clinical outcomes of Sangamo’s zinc finger nuclease (ZFN)-generated CCR5-modified, autologous T-cell product (SB-728-T) for the treatment of HIV/AIDS. [Press release from Sangamo BioSciences, Inc. discussing research presented at the Conference on Retroviruses and Opportunistic Infections]
UCLA and Sound Pharmaceuticals Identify a Key Hearing Regeneration Protein in the Human Inner Ear
In collaboration with scientists and clinicians from the University of California Los Angeles, scientists from Sound Pharmaceuticals have found p27Kip1 to be expressed in the adult and aged human inner ear including the auditory and vestibular sensory organs. These findings are identical to what has been observed and reported in neonatal and adult rodents, further validating p27Kip1 as a key regeneration target in the deafened mammalian inner ear. [Press release from PR Newswire discussing research presented at the 34th Annual Midwinter Meeting of the Association for Research in Otolaryngology]