Researchers Inject Nanofiber Spheres Carrying Cells into Wounds to Grow Tissue For the first time, scientists have made star-shaped, biodegradable polymers that can self-assemble into hollow, nanofiber spheres, and when the spheres are injected with cells into wounds, these spheres biodegrade, but the cells live on to form new tissue. [Press release from the University of Michigan discussing online prepublication in Nature Materials] Decoding Cancer Patients’ Genomes Is Powerful Diagnostic Tool Two new studies highlight the power of sequencing cancer patients’ genomes as a diagnostic tool, helping doctors decide the best course of treatment and researchers identify new cancer susceptibility mutations that can be passed from parent to child. [Press release from Washington University in St. Louis discussing online prepublication in the Journal of the American Medical Association] Enhanced Cord Blood Stem Cell Transplants Safe in Long-Term Studies An innovative experimental treatment for boosting the effectiveness of stem-cell transplants with umbilical cord blood has a favorable safety profile in long-term animal studies, report scientists. [Press release from ScienceDaily discussing online prepublication in Cell Stem Cell]
New Study Finds Better Strategy for Lymphoma Immunotherapy An extra boost to extend the cancer-fighting power of specially engineered immune system cells proved effective in a preliminary study involving six lymphoma patients, said researchers. [Press release from Baylor College of Medicine discussing online prepublication in the Journal of Clinical Investigation]
Simple Injection Could Limit Damage from Heart Attacks and Stroke Medical researchers held out promise that a simple injection is being developed to limit the devastating consequences of heart attacks and strokes. They identified an enzyme, mannan binding lectin-associated serine protease-2, that is found in blood and is a key component of the lectin pathway of complement activation, a component of the innate immune system. [Press release from the University of Leicester discussing online prepublication in the Proceedings of the National Academy of Science] Scientists Identify a Surprising New Source of Cancer Stem Cells Researchers have discovered that a differentiated cell type found in breast tissue can spontaneously convert to a stem-cell-like state, the first time such behavior has been observed in mammalian cells. [Press release from Whitehead Institute for Biomedical Research discussing online prepublication in the Proceedings of the Natural Academy of Science] Potential New Blood Test and Treatment for Breast Cancer Announced by Sialix, Inc. and Researchers at the University of California, San Diego Sialix, Inc. announced the results of a study it participated in that could have significant impact in the prediction, early detection and treatment of cancer in humans. [Press release from the Sialix, Inc. discussing online prepublication in Cancer Research] A Cancer Marker and Treatment in One? Researchers say antibodies to a non-human sugar molecule commonly found in people may be useful as a future biomarker for predicting cancer risk, for diagnosing cancer cases early and, in sufficient concentration, used as a treatment for suppressing tumor growth. [Press release from the University of California, San Diego discussing online prepublication in Cancer Research] Louisiana State University Health Sciences Center Research Discovery May Block ALS Disease Process In the first animal model of amyotrophic lateral sclerosis (ALS), researchers have found in fruit flies that blocking the abnormal movement of a protein made by a mutated gene called FUS also blocks the disease process. [Press release from EurekAlert! discussing online prepublication in Human Molecular Genetics] Improved Recovery of Motor Function After Stroke Scientists report a two-pronged molecular therapy that leads to significant recovery of skilled motor function in a rat model of stroke. [Press release from Children’s Hospital Boston discussing online prepublication in the Journal of Neuroscience]
University of Southern California, Massachusetts Institute of Technology Researchers Develop Gene Therapy with Potential to Restore Sight to the Blind Researchers have developed a potential therapy for blindness that involves delivering a gene encoding a light-sensitive protein to inner retinal cells, enabling photosensitivity in these cells and restoring visual function in mouse models. [Press release from the Massachusetts Institute of Technology discussing online prepublication in Molecular Therapy] Scientists Engineer Nanoscale Vaults to Encapsulate ‘Nanodisks’ for Drug Delivery Scientists demonstrated the ability to package drug-loaded “nanodisks” into vault nanoparticles, naturally occurring nanoscale capsules that have been engineered for therapeutic drug delivery. [Press release from the University of California, Los Angeles discussing online prepublication in Small] Cancer Breath Test ‘Step Closer’ Researchers found an “electronic nose” was able to identify chemical signals of cancer in the breath of patients with lung or head and neck cancer. [Press release from BBC discussing online prepublication in the British Journal of Cancer]
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