|
TOP STORY |
Purged Versus Non-Purged Peripheral Blood Stem-Cell Transplantation for High-Risk Neuroblastoma (COG A3973): A Randomized Phase III Trial Myeloablative chemoradiotherapy and immunomagnetically purged autologous bone marrow transplantation has been shown to improve outcome for patients with high-risk neuroblastoma. Currently, peripheral blood stem cells (PBSC) are infused after myeloablative therapy, but the effect of purging is unknown. Researchers conducted a randomized study of tumor-selective PBSC purging in stem-cell transplantation for patients with high-risk neuroblastoma. [Lancet Oncol] Abstract | Press Release |
PUBLICATIONS (Ranked by impact factor of the journal) |
hESC-Derived Olig2+ Progenitors Generate a Subtype of Astroglia with Protective Effects against Ischaemic Brain Injury Researchers used an Olig2-GFP human embryonic stem cell (hESC) reporter to demonstrate that hESC-derived Olig2+ progenitors generate a subtype of previously uncharacterized astroglia (Olig2PC-Astros). When grafted into brains subjected to global ischaemia, Olig2PC-Astros exhibit superior neuroprotective effects and improved behavioral outcome compared to Olig2-negative hESC-derived neural progenitor cells. [Nat Commun] Full Article | Press Release Myeloid/Microglial Driven Autologous Hematopoietic Stem Cell Gene Therapy Corrects a Neuronopathic Lysosomal Disease N-Acetylcysteine Amide (NACA) Augments the Therapeutic Effect of Neural Stem Cell-Based Anti-Glioma Oncolytic Virotherapy TAT-Hsp70 Induces Neuroprotection against Stroke via Anti-Inflammatory Actions Providing Appropriate Cellular Microenvironment for Transplantation of Neural Precursor Cells Survival and Differentiation of Adenovirus-Generated Induced Pluripotent Stem Cells Transplanted into the Rat Striatum Mesenchymal Stem Cells from iPS Cells Facilitate Periodontal Regeneration CXCR4-Overexpressing Bone Marrow-Derived Mesenchymal Stem Cells Improve Repair of Acute Kidney Injury Apoptotic Cell Administration Enhances Pancreatic Islet Engraftment by Induction of Regulatory T Cells and Tolerogenic Dendritic Cells In Situ Tissue Engineering with Synthetic Self-Assembling Peptide Nanofiber Scaffolds, PuraMatrix, for Mucosal Regeneration in the Rat Middle-Ear |
REVIEWS |
Mesenchymal Stem Cells in Joint Disease and Repair Mesenchymal stem cells (MSCs)-multipotent precursors of connective tissue cells that can be isolated from many adult tissues, including those of the diarthrodial joint-have emerged as a potential therapy for osteoarthritis. Several early-stage clinical trials, initiated or underway in 2013, are testing the delivery of MSCs as an intra-articular injection into the knee, but optimal dose and vehicle are yet to be established. [Nat Rev Rheumatol] Abstract Cord Blood Transplantation for Cure of HIV Infections Visit our reviews page to see a complete list of reviews in the cell, gene and immunotherapy research field. |
SCIENCE NEWS |
OncoSec Medical Presents Positive Immune Response Data from Phase II Study at the 8th World Congress OncoSec Medical Inc., a company developing its advanced-stage ImmunoPulse DNA-based immunotherapy and NeoPulse therapy to treat solid tumors, announced interim immune response data from the company’s Phase II study of ImmunoPulse in patients with metastatic melanoma. [Press release from OncoSec Medical Inc. discussing research presented at the 8th World Congress of Melanoma, Hamburg] Press Release |
POLICY |
Democratizing the Collection and Storage of Stem Cells Cordsavings SA, newly housed at the BioArk site in Monthey, seeks to democratize the collection and storage of umbilical cord blood stem cells across Swiss territory. To achieve this, it is developing a totally new ethical and community-based bio-bank in Valais to serve families and the public health authorities. [Cordsavings SA] Press Release BrainStorm’s NurOwn Cell Therapy Receives Orphan Drug Designation in the European Union for ALS |
BUSINESS |
Stem Cell Agency’s Board Approves $70 Million Plan to Develop Innovative Alpha Clinics A $70 million plan to create a new statewide network of sites that will act as a hub for stem cell clinical trials was approved by the governing Board of California’s stem cell agency, the California Institute for Regenerative Medicine. The goal of the Alpha Stem Cell Clinics Network is to support and accelerate clinical trials for programs funded by the agency, as well as those developed elsewhere by academic researchers, clinicians and pharmaceutical companies. [California Institute for Regenerative Medicine] Press Release Stem Cell Clinical Trials Expert to Lead Cardiology Division at Cedars-Sinai Heart Institute International Regenerative Medicine Expert Joins University SynGen Hires Former Pall Medical Executive as President of Cord Blood Business Unit Adaptimmune Announces Opening of Phase I/IIa Clinical Trial in Ovarian Cancer Cellular Biomedicine Group Completes Enrollment in Phase I Clinical Trial for Knee Osteoarthritis Arrowhead Begins Phase I Trial of RNAi Therapeutic ARC-520 for Treatment of Chronic Hepatitis B Infection LifeMap Sciences Announces Release of LifeMap Discovery™ Version 1.2 with Extensive Stem Cell Therapy Data |
NIH |
Proposed Collection; 60-Day Comment Request: Application for the Postdoctoral Research Associate Program (FR Doc No: 2013-17645) |
REGULATORY |
Food and Drug Administration (United States) Cellular, Tissue and Gene Therapies Advisory Committee; Notice of Meeting (FR Doc No: 2013-17600) |
EVENTS |
NEW Compliance Made Easy for Cord Blood Banks July 31, 11:00AM (CT in US) Webinar NEW 3rd Geneocell Summer School: Advanced Stem Cell Technologies & Therapies NEW Cell Society Europe Congress Visit our events page to see a complete list of events in the cell, gene and immunotherapy community. |
JOB OPPORTUNITIES |
NEW Research Associate – Cardioprotection and Myocardium Repair by Gene or Cell Therapy (University of Louisville) Postdoctoral Fellowship – Immunology (Johns Hopkins University School of Medicine) Postdoctoral Fellowship – Organic Synthesis and Medicinal Chemistry (Masaryk University) Director of Cell Processing Facility (S L Collins Associates, Inc.) Postdoctoral Researcher – Hematopoietic Stem Cells (Albert Einstein College of Medicine) |
SUBSCRIBER TOOLS: | |||
Profile Center | Connexon Publications | Article Submission | Contact Us |