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TOP STORY |
Heart’s Own Stem Cells Offer Hope for New Treatment of Heart Failure Researchers have for the first time highlighted the natural regenerative capacity of a group of stem cells that reside in the heart. This new study shows that these cells are responsible for repairing and regenerating muscle tissue damaged by a heart attack which leads to heart failure. [Press release from King’s College London discussing online prepublication in Cell] Press Release | Abstract | Graphical Abstract |
PUBLICATIONS (Ranked by impact factor of the journal) |
Inhibition of p300 Impairs Foxp3+ T Regulatory Cell Function and Promotes Antitumor Immunity Scientists report that conditional deletion or pharmacologic inhibition of one histone/protein acetyltransferase, p300 (also known as Ep300 or KAT3B), in Foxp3+ Treg cells increased T cell receptor-induced apoptosis in Treg cells, impaired Treg cell suppressive function and peripheral Treg cell induction, and limited tumor growth in immunocompetent but not in immunodeficient mice. [Nat Med] Abstract | Press Release Complement Anaphylatoxin C3a Is a Potent Inducer of Embryonic Chick Retina Regeneration Transplants of Adult Mesenchymal and Neural Stem Cells Provide Neuroprotection and Behavioral Sparing in a Transgenic Rat Model of Huntington’s Disease The miR-223/Nuclear Factor I-A Axis Regulates Glial Precursor Proliferation and Tumorigenesis in the CNS Polydopamine-Assisted Osteoinductive Peptide Immobilization of Polymer Scaffolds for Enhanced Bone Regeneration by Human Adipose-Derived Stem Cells Adipose Tissue-Derived Stromal Stem Cell Therapy in Murine ConA-Derived Hepatitis Is Dependent on Myeloid-Lineage and CD4+ T-Cell Suppression Human Umbilical Cord Mesenchymal Stem Cell Therapy for Patients with Active Rheumatoid Arthritis: Safety and Efficacy Adipose Tissue-Derived Stem Cells (ADSCs) Transplantation Promotes Regeneration of Expanded Skin Using a Tissue Expansion Model Enhancing In Vivo Survival of Adipose-Derived Stromal Cells through Bcl-2 Overexpression Using a Minicircle Vector |
REVIEWS |
Back to the Future: How Human Induced Pluripotent Stem Cells will Transform Regenerative Medicine This review discusses here are recent developments in the field as they relate to regenerative medicine, with an emphasis on creating functional cells, editing their genome, autologous transplantation and how this ground-breaking field may eventually impact human aging. [Hum Mol Genet] Abstract | Full Article Visit our reviews page to see a complete list of reviews in the cell, gene and immunotherapy research field. |
SCIENCE NEWS |
Bavituximab’s Mechanism of Action Highlighted at Immunomodulatory Therapeutic Antibodies for Cancer Conference Peregrine Pharmaceuticals, Inc. announced the presentation of preclinical data and ongoing drug development activities highlighting the immune-stimulatory mechanism of action of phosphatidylserine (PS)-targeting antibodies, such as the company’s lead drug candidate bavituximab. Data from this presentation showed that PS-targeting antibodies block a primary upstream immune checkpoint, thus inhibiting PS from engaging its natural receptors on immune cells, resulting in multiple downstream immunostimulatory effects. [Press release from Peregrine Pharmaceuticals, Inc. discussing research presented at the Cambridge Healthtech Institute’s Immunotherapies Congress, Boston] Press Release Grafix® Demonstrates Overwhelming Efficacy in Landmark Stem Cell Study for the Treatment of Diabetic Foot Ulcers |
POLICY |
DOH Gives Health Facilities Engaged in Stem Cell Therapy until Aug. 31 to Register The Philippines Department of Health (DOH) has given all health facilities practicing stem cell therapy and companies importing and producing stem cell products until Aug. 31 to apply for accreditation and product registration, respectively. Nick Lutero, director of the DOH-Bureau of Health Facilities and Services, said it will be considered illegal for facilities to do stem cell procedures if they fail to comply with the requirement. [Philippines Department of Health] Press Release $250 Million Regenerative Medicine Plan Part of Rudd Labor Health Policy From our sponsor: |
BUSINESS |
BioLife Solutions Expands Strategic Relationship with STEMCELL Technologies Inc. BioLife Solutions, Inc. announced an expansion of its relationship with STEMCELL Technologies Inc. Since August 2009, STEMCELL Technologies has distributed BioLife’s biopreservation media products to the worldwide research and clinical biobanking communities. [BioLife Solutions, Inc.] Press Release Stem Cell Research Lab to Open at Tehnopol Cystinosis Research Foundation Awards $1.29 Million in Grants to Find a Cure for Deadly Genetic Disease FDA Approves MSC-NP Therapy as Investigational New Drug in MS Clinical Trial: A Research Milestone Alnylam Receives Orphan Drug Designation from U.S. Food & Drug Administration for ALN-AT3, an RNAi Therapeutic for the Treatment of Hemophilia AlloSource Launches AlloMend: Allograft Offers New Possibilities in Soft Tissue Repair MRI Interventions’ ClearPoint System Enables Precise Delivery of Promising Investigational Gene Therapy in Parkinson’s Disease Phase I Clinical Trial Celldex Announces Expansion of Phase II ReACT Study in Recurrent Glioblastoma Medistem Announces Patent Application on Stem Cell Secreted Nanoparticles (Exosomes) Verastem Issued U.S. Patent Covering VS-4718 Composition of Matter Arcturus Therapeutics Acquires Cutting-Edge UNA Patent Estate from Marina Biotech |
CBER |
Consolidation of Wound Care Products Containing Live Cells |
EVENTS |
NEW Harnessing New Players in Atherosclerosis to Treat Heart Disease September 24, 2013 New York, United States NEW Genetic Engineering of Mammalian Stem Cells March 10-22, 2014 Cambridge, United Kingdom NEW Clinical Translation of Stem Cells Visit our events page to see a complete list of events in the cell, gene and immunotherapy community. |
JOB OPPORTUNITIES |
NEW Research Associate – Human Induced Pluripotent Stem Cell Initiative (King’s College London) Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.) Tenure-Track Position – Cell Biologist (McGill University) Postdoctoral Positions – AIDS Vaccine and Human Gene Therapy (GeneCure Biotechnologies) Postdoctoral Fellowship – Immunology (Johns Hopkins University School of Medicine) Director of Cell Processing Facility (S L Collins Associates, Inc.) Postdoctoral Researcher – Hematopoietic Stem Cells (Albert Einstein College of Medicine) |
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