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TOP STORY |
Modified mRNA Directs the Fate of Heart Progenitor Cells and Induces Vascular Regeneration after Myocardial Infarction Scientists showed that intramyocardial injection of synthetic modified RNA encoding human vascular endothelial growth factor-A results in the expansion and directed differentiation of endogenous heart progenitors in a mouse myocardial infarction model. [Nat Biotechnol] Abstract | Press Release |
PUBLICATIONS (Ranked by impact factor of the journal) |
Identification of Human Nephron Progenitors Capable of Generation of Kidney Structures and Functional Repair of Chronic Renal Disease Scientists showed that growth of human fetal kidneys in serum-free defined conditions and prospective isolation of NCAM1+ cells selects for nephron lineage that includes the SIX2-positive cap mesenchyme cells identifying a mitotically active population with in vitro clonogenic and stem/progenitor properties. After transplantation in the chick embryo, these cells – but not differentiated counterparts – efficiently formed various nephron tubule types. [EMBO Mol Med] Full Article Minimally Invasive Transplantation of iPSC-Derived ALDHhiSSCloVLA4+ Neural Stem Cells Effectively Improves the Phenotype of an Amyotrophic Lateral Sclerosis Model Intranasal Delivery of Mesenchymal Stem Cells Significantly Extends Survival of Irradiated Mice with Experimental Brain Tumors Exploiting Human CD34+ Stem Cell-Conditioned Medium for Tissue Repair Replacement of a Tracheal Stenosis with a Tissue-Engineered Human Trachea using Autologous Stem Cells – A Case Report Cooperation by Fibroblasts and Bone Marrow-Mesenchymal Stem Cells to Improve Pancreatic Rat-to-Mouse Islet Xenotransplantation A Novel Oxysterol Promotes Bone Regeneration in Rabbit Cranial Bone Defects Allogeneic Stem Cells from Deciduous Teeth Mediated Treatment for Periodontitis in Miniature Swine Age of the Donor Reduces the Ability of Human Adipose-Derived Stem Cells to Alleviate Symptoms in the Experimental Autoimmune Encephalomyelitis Mouse Model Administration of Murine Stromal Vascular Fraction Ameliorates Chronic Experimental Autoimmune Encephalomyelitis |
REVIEWS |
Chemical Approaches to Stem Cell Biology and Therapeutics Researchers discuss recent scientific and therapeutic progress, as well as new perspectives and future challenges for using chemical approaches in stem cell biology and regenerative medicine. [Cell Stem Cell] Abstract The Role of Mesenchymal Stromal Cells in Spinal Cord Injury, Regenerative Medicine and Possible Clinical Applications Visit our reviews page to see a complete list of reviews in the cell, gene and immunotherapy research field. |
SCIENCE NEWS |
Cellular Biomedicine Group Announces Positive Interim Results from Phase I/IIa Clinical Trial for Treatment of Knee Osteoarthritis (KOA) Cellular Biomedicine Group, Inc. announced the interim results of its Phase I/IIa clinical trial for human adipose-derived mesenchymal precursor cell (haMPC) therapy for KOA, which tests the safety and efficacy of intra-articular injections of autologous (patient’s own) haMPCs in order to reduce inflammation and repair damaged joint cartilage. [Cellular Biomedicine Group, Inc.] Press Release |
POLICY | ||||
Sequester Cuts May Delay Drug Approvals – and More The United States Congress’s current mandatory budget cuts – sequestration – threaten unprecedented opportunities in all biomedical research and development. These severe cuts raise the particular concern that translation of intricate knowledge about the molecular biology of cancer to new, targeted treatments will be impeded in part by an underfunded U.S. Food and Drug Administration. [Sci Transl Med] Editorial Abe Funds Stem Cells to Help Cure Japan Wasting Disease
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BUSINESS |
Novartis Announces an Exclusive Global Licensing and Research Collaboration with Regenerex Novartis announced that it has entered into an exclusive global licensing and research collaboration agreement with Regenerex LLC for use of the company’s novel Facilitating Cell Therapy (FCRx) platform. The hematopoietic stem cell-based FCRx platform has been investigated in kidney transplantation to induce stable immunological tolerance, resulting in graft survival without the need for lifelong immunosuppression. [Novartis AG] Press Release Biogen Idec and Isis Pharmaceuticals Announce Strategic Collaboration to Advance Treatment of Neurological Disorders America Stem Cell, Inc. Receives FDA Clearance for Its Multi-Center Nationwide Trial SanBio Announces the Completion of Enrollment of Its Clinical Trial of Cell Therapy for Chronic Stroke Deficits Stem Cell Therapeutics Advances CD47 Antagonist Program into IND-Enabling Phase Targeted Medical Pharma Initiates Clinical Trial of Red Blood Cell Stimulating Formulation New Hub Forms Part of ‘Industrial Revolution’ in Regenerative Medicine BIDMC Awarded NIH Grant to Study New Treatment for Spinal Cord Injuries BioLife Solutions Provides Update on Clinical Use of CryoStor® and HypoThermosol® Cell and Tissue Biopreservation Media Products From our sponsor: Free mouse hematopoietic progenitors wallchart. Request your copy. |
NIH |
National Cancer Institute; Amended Notice of Meeting (FR Doc No: 2013-21395) Center for Scientific Review; Notice of Closed Meetings (FR Doc No: 2013-21785) |
EVENTS |
NEW Cancer Therapeutics 2013: From Bench to Bedside November 4-6, 2013 La Jolla, United States Visit our events page to see a complete list of events in the cell, gene and immunotherapy community. |
JOB OPPORTUNITIES |
NEW Doctoral Position in Bioengineering (University of Genoa) NEW Postdoctoral Position – Leukemia Biology (Northwestern University) Cellular Therapy Lab Specialist (University of Texas Medical School at Houston) Postdoctoral Research Fellow – Bioengineering (Fred Hutchinson Cancer Research Center) Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.) Postdoctoral Positions – AIDS Vaccine and Human Gene Therapy (GeneCure Biotechnologies) |
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