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Early Stem Cell Transplants Evaluated for Non-Hodgkins Lymphoma Patients at High Risk of Early Relapse Performing early stem cell transplants in patients with aggressive non-Hodgkin’s lymphoma does not improve overall survival in high-risk patients. But early transplantation does appear to be beneficial among a small group of patients who are at the very highest risk. [Press release from Loyola University Chicago discussing research published in the New England Journal of Medicine] Press Release | Abstract |
PUBLICATIONS (Ranked by impact factor of the journal) |
Human Treg Responses Allow Sustained Recombinant Adeno-Associated Virus-Mediated Transgene Expression Recombinant adeno-associated virus (rAAV) vectors have shown promise for the treatment of several diseases; however, immune-mediated elimination of transduced cells has been suggested to limit and account for a loss of efficacy. To determine whether rAAV vector expression can persist long term, researchers administered rAAV vectors expressing normal, M-type α-1 antitrypsin to AAT-deficient subjects at various doses by multiple i.m. injections. [J Clin Invest] Full Article | Press Release SUMO-1 Gene Transfer Improves Cardiac Function in a Large-Animal Model of Heart Failure Aldehyde Dehydrogenase Expression Drives Human Regulatory T Cell Resistance to Posttransplantation Cyclophosphamide Hypoxic Mesenchymal Stem Cells Engraft and Ameliorate Limb Ischemia in Allogeneic Recipients Guidance of In Vitro Migration of Human Mesenchymal Stem Cells and In Vivo Guided Bone Regeneration Using Aligned Electrospun Fibers Allogeneic Human Mesenchymal Stem Cell Therapy (Remestemcel-L, Prochymal®) as a Rescue Agent for Severe Refractory Acute GvHD in Pediatric Patients MSCs versus MSCs Combined with CB for Engraftment Failure Following Autologous Hematopoietic Stem Cell Transplantation: A Pilot Prospective, Open-Labeled, Randomized Trial Extrahepatic Stem Cells Mobilized from the Bone Marrow by the Supplementation of BCAA Ameliorate Liver Regeneration in an Animal Model A Novel Three-Dimensional Adipose-Derived Stem Cell Cluster for Vascular Regeneration in Ischemic Tissue Human Salivary Gland Stem Cells Ameliorate Hyposalivation of Radiation-Damaged Rat Salivary Glands |
REVIEWS |
Genetically Modified Hematopoietic Stem Cell Transplantation for HIV-1 Infected Patients: Can We Achieve a Cure? The authors discuss results from early stage clinical trials and recent findings in animal models of gene modified hematopoietic stem cell transplantation. They also propose innovative combination therapies that may aid in the reduction and/or elimination of viral reservoirs in HIV-1 infected patients and promote the artificial development of a natural controller phenotype. [Mol Ther] Abstract Visit our reviews page to see a complete list of reviews in the cell, gene and immunotherapy research field. |
SCIENCE NEWS |
Multipotent Stem Cell Proteins Support Soft Tissue Regeneration Through its proprietary technology process that simulates the conditions of the embryonic environment, Histogen has developed a human extracellular matrix (hECM) material composed of stem cell-associated proteins including SPARC, decorin, collagens I,III,IV, V, fibronectin, fibrillin, laminins, and hyaluronic acid. [Press release from Histogen, Inc. discussing research presented at the Tissue Engineering and Regenerative Medicine International Society (TERMIS) Americas Annual Meeting, Atlanta] Press Release LVAD Patients Benefit from Heart Injection with Millions of Powerful Cells Sangamo BioSciences Announces Presentation Of Clinical Data from Alzheimer’s Disease Program Advanced Melanoma Patients’ Long-Term Survival Improved with California Stem Cell, Inc.’s Patient Specific Cell Therapy Additional Interim Data for Merck’s Investigational Anti-PD-1 Immunotherapy, MK-3475, Shows Estimated Overall Survival Rate of 81 Percent at One Year in Patients with Advanced Melanoma From our sponsor: Free wallchart from Nature Neuroscience – Neural Stem Cells. Request your copy. |
POLICY |
Regenerative Medicine Certification System Eyed The Japanese Society for Regenerative Medicine (JSRM) will establish a certification system for physicians with expertise and skills in regenerative medicine and for medical technicians adept at cell culturing techniques as early as next fall, JSRM officials said. [The Japan Times] Editorial House Hearing Skates Over Big Disagreements on NSF Reauthorization Open-Access Group Sanctions Three Publishers After Science ‘Sting’ |
BUSINESS |
Austrianova Announces Exclusive Licensing Deal with Nuvilex Inc for Use of Cell-in-a-Box® Encapsulated Cell Technology for Diabetes Treatment Austrianova announced that Nuvilex, Inc has acquired the exclusive world-wide rights to use Austrianova’s cellulose-based live-cell encapsulation technology for the development of certain cell-type based treatments for diabetes in a multi-million dollar deal. [AustriaNova] Press Release immatics and Roche Sign Cancer Vaccine and Immunotherapy Collaboration MultiCell Technologies Files U.S. Patent Application for Targeted Delivery of MCT-485, a Noncoding miRNA for Cancer Treatment ViGene Biosciences Introduces World’s Largest Collection of Pre-Made Human Full-Length cDNA ORF and miRNA Adenoviruses Cardio3 BioSciences Announces Q3 2013 Business Update and Authorization to Enroll Patients in Poland in Its CHART-1 Phase III Clinical Trial CEL-SCI Receives Croatian Government Approval to Commence Phase III Clinical Trial of Multikine in Head and Neck Cancer Opexa Therapeutics Selected as a “Top 10 Advanced Therapy Projects to Watch” Life Stem Genetics Announces James Vanden Bosch as Chief Medical Stem Cell Specialist |
NIH |
Center for Scientific Review Amended; Notice of Meeting (FR Doc No: 2013-27355) Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc No: 2013-27348) |
REGULATORY |
Food and Drug Administration (United States) FDA Safety Communication: New Boxed Warning for Thrombosis Related to Human Immune Globulin Products |
EVENTS |
NEW 4th International Conference on Stem Cell Engineering March 16-19, 2014 Coronado, United States Visit our events page to see a complete list of events in the cell, gene and immunotherapy community. |
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