Generation of a New Therapeutic Peptide that Depletes Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice Researchers adapted a competitive peptide phage display platform to identify candidate peptides binding myeloid-derived suppressor cells (MDSCs) specifically and generated peptide-Fc fusion proteins (peptibodies). In multiple tumor models, intravenous peptibody injection completely depleted blood, splenic and intratumoral MDSCs in tumor-bearing mice without affecting proinflammatory immune cell types, such as dendritic cells. [Nat Med] Abstract | Press Release Photoactivation of Endogenous Latent Transforming Growth Factor-β1 Directs Dental Stem Cell Differentiation for Regeneration Scientists showed that non-ionizing, low-power laser treatment can be used as a minimally invasive tool to activate an endogenous latent growth factor complex, transforming growth factor-β1, that subsequently differentiates host stem cells to promote tissue regeneration. [Sci Transl Med] Abstract | Press Release Improved Survival with T Cell Clonotype Stability after Anti-CTLA-4 Treatment in Cancer Patients Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) blockade in patients with metastatic castration-resistant prostate cancer and metastatic melanoma resulted in both expansion and loss of T cell clonotypes, consistent with a global turnover of the T cell repertoire. [Sci Transl Med] Abstract | Press Release Transplanted Terminally Differentiated Induced Pluripotent Stem Cells Are Accepted by Immune Mechanisms Similar to Self-Tolerance Scientists showed in murine models that autologous induced pluripotent stem cell-derived endothelial cells elicit an immune response that resembles the one against a comparable somatic cell, the aortic endothelial cell. [Nat Commun] Abstract | Press Release In Utero Depletion of Fetal Hematopoietic Stem Cells Improves Engraftment after Neonatal Transplantation in Mice Scientists used an antibody against the murine c-Kit receptor (ACK2) to deplete fetal host hematopoietic stem cells and increase space within the hematopoietic niche for donor cell engraftment. Fetal mice were injected with ACK2 on E13.5-14.5 and surviving pups were transplanted with congenic hematopoietic cells on day of life one. [Blood] Abstract Effect of HMGB1 on the Paracrine Action of EPC Promotes Post-Ischemic Neovascularization in Mice In vivo studies showed hPB-endothelial progenitor cells (EPCs) transplantation improved neurobehavioral outcomes, reduced brain atrophy volume and enhanced neovascularization in transient middle cerebral artery occlusion mice. [Stem Cells] Abstract Dual-Regulated Lentiviral Vector for Gene Therapy of X-Linked Chronic Granulomatosis X-linked chronic granulomatous disease mice transplanted with transduced hematopoietic stem cell restored gp91phox expression, and myeloid-specific promoter-driven vectors maintained regulation during BM development. [Mol Ther] Abstract Silencing Mutant Huntingtin by Adeno-Associated Virus-Mediated RNA Interference Ameliorates Disease Manifestations in the YAC128 Mouse Model of Huntington’s Disease Scientists examined the merits of administering a recombinant adeno-associated viral vector designed to deliver small interfering RNA that targets the degradation of the huntingtin transcript. [Hum Gene Ther] Abstract | Press Release Therapeutic Effect of Bone Marrow Mesenchymal Stem Cells on Laser-Induced Retinal Injury in Mice Researchers investigated the therapeutic potential of bone marrow mesenchymal stem cells by systemic transplantation in a laser-induced retinal injury model. [Int J Mol Sci] Abstract | Download Full Article |