| PUBLICATIONS (Ranked by impact factor of the journal) | Radiation and Dual Checkpoint Blockade Activate Non-Redundant Immune Mechanisms in Cancer Researchers report major tumor regressions in a subset of patients with metastatic melanoma treated with an anti-CTLA4 antibody and radiation, and reproduced this effect in mouse models. [Nature] Abstract | Press Release Five-Year Survival Rates for Treatment-Naive Patients with Advanced Melanoma who Received Ipilimumab plus Dacarbazine in a Phase III Trial To demonstrate a long-term survival benefit with ipilimumab, investigators evaluated the five-year survival rates of patients treated in a randomized, controlled Phase III trial. [J Clin Oncol] Abstract | Press Release Generation of Human Memory Stem T Cells upon Haploidentical T-Replete Hematopoietic Stem Cell Transplantation Investigators longitudinally tracked memory stem T cells dynamics in patients undergoing haploidentical hematopoietic stem cell transplantation, thereby providing novel hints on the contribution of this subset to post transplant immune reconstitution in humans. [Blood] Abstract DAP12-Based Activating Chimeric Antigen Receptor for NK Cell Tumor Immunotherapy On the basis of DNAX-activation protein 12 (DAP-12), a signaling adaptor molecule involved in signal transduction of activating NK cell receptors, scientists generated a new type of chimeric Ag receptor targeting the prostate stem cell Ag (PSCA). Infused YTS cells armed with anti-PSCA-DAP12 caused delayed tumor xenograft growth and resulted in complete tumor eradication in a significant fraction of treated mice. [J Immunol] Abstract Tolerance of Activated Pathogenic CD4+ T Cells by Transcriptional Targeting of Dendritic Cells The authors recently showed that targeted expression of myelin oligodendrocyte glycoprotein to dendritic cells with self-inactivating-lentivirus vectors induces antigen-specific tolerance in naive antigen-specific CD4+ T cells and protects mice from experimental autoimmune encephalomyelitis (EAE). They now demonstrate that this approach also induces tolerance of activated antigen-specific CD4+ T cells and completely protects mice from passive EAE induction. [Gene Ther] Abstract Dental Pulp Stem Cells: A New Cellular Resource for Corneal Stromal Regeneration Researchers report that adult dental pulp cells (DPCs) isolated from third molars have the capability to differentiate into keratocytes, cells of the corneal stoma. After injection in vivo into mouse corneal stroma, human DPCs produced corneal stromal extracellular matrix containing human type I collagen and keratocan and did not affect corneal transparency or induce immunological rejection. [Stem Cells Transl Med] Abstract | Press Release Innovative Delivery of siRNA to Solid Tumors by Super Carbonate Apatite Investigators introduce an in vivo pH-sensitive delivery system for small interfering RNA (siRNA) using super carbonate apatite nanoparticles, which is the smallest class of nanocarrier. [PLoS One] Full Article Enhanced Engraftment and Repairing Ability of Human Adipose-Derived Stem Cells, Conveyed by Pharmacologically Active Microcarriers Continuously Releasing HGF and IGF-1, in Healing Myocardial Infarction in Rats Rats with four-week-old myocardial infarction were injected in the border zone with human adipose-derived stem cells conveyed by poly(lactic-co-glycolic acid) microcarriers releasing hepatocyte growth factor (HGF) and insulin-like growth factor-1 (IGF-1). [J Biomed Mater Res A] Abstract Double-Blind, Placebo-Controlled Study of HGF Gene Therapy in Diabetic Neuropathy Investigators aimed to evaluate the safety and efficacy of a plasmid containing two human hepatocyte growth factor isoforms given by intramuscular injections in patients with painful diabetic neuropathy. [Ann Clin Transl Neurol] Full Article | Press Release |
| POLICY | In Japan, Embattled RIKEN Chief to Step Down Ryoji Noyori plans to resign as president of RIKEN, the network of Japanese national labs that has spent much of the past year embroiled in a fraud scandal, news outlets report. [ScienceInsider] Editorial Europe’s Human Brain Project Needs Urgent Reforms, Panel Says The Human Brain Project, a humongous, controversial research project backed by the European Union, must reform to stay on course, a review panel has recommended and it must do so fast. A summary of the panel’s report, published by the European Commission, says a series of “corrective actions” needs to be taken in HBP’s governance, the way it collaborates, and its communication. [ScienceInsider] Editorial | Download Report Harper Government Supports Innovation in Immunotherapy Treatments The Honourable Michelle Rempel, Minister of State for Western Economic Diversification, announced funding of $2,167,000 to The Centre for Drug Research and Development (CDRD) to support them in the development and commercialization of innovative treatments for human disease in the field of immunotherapy. [The Centre for Drug Research and Development] Press Release |
| BUSINESS | CIRM-Funded Clinical Trial Aimed at Blocking HIV/AIDS in People Gets the Go Ahead An innovative therapy using a patient’s own stem cells, modified to resist infection with the AIDS virus, has been given approval by the Food and Drug Administration to begin a clinical trial in people. CIRM, California’s stem cell agency, is funding that trial. [California Institute for Regenerative Medicine] Press Release The Bill & Melinda Gates Foundation and CureVac Collaborate to Accelerate the Development of Transformative Vaccine Technology The Bill & Melinda Gates Foundation and CureVac announced that the foundation has made a commitment to invest $52 million in CureVac. As part of the agreement, the foundation will also provide separate funding for several projects to develop prophylactic vaccines based on CureVac’s proprietary mRNA platform. [Bill & Melinda Gates Foundation] Press Release Bristol-Myers Squibb Signs Exclusive Agreement with Bavarian Nordic for PROSTVAC®, a Prostate-Specific Antigen-Targeting Cancer Immunotherapy Bavarian Nordic and Bristol-Myers Squibb Company announced an agreement that provides Bristol-Myers Squibb an exclusive option to license and commercialize PROSTVAC®, Bavarian Nordic’s investigational Phase III prostate-specific antigen-targeting cancer immunotherapy in development for the treatment of asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer. [Bristol-Myers Squibb Company] Press Release Athersys and Chugai Enter License Agreement and Collaboration to Develop MultiStem® Cell Therapy for Ischemic Stroke in Japan Athersys, Inc. and Chugai Pharmaceutical Co., Ltd. have announced a partnership and license agreement to exclusively develop and commercialize MultiStem® cell therapy for ischemic stroke in Japan. [Athersys, Inc.] Press Release Celimmune Announces Anti-IL-15 Antibody Licensing and Option Agreements with Amgen Celimmune LLC announced that it has licensed a Phase II-stage, anti-IL-15 monoclonal antibody (AMG 714) from Amgen. Under the provisions of this exclusive license agreement, Celimmune has the rights to develop, manufacture and commercialize AMG 714 on a worldwide basis excluding Japan. [Celimmune LLC (PR Newswire Association LLC)] Press Release Orgenesis Acquires Cell Therapy Manufacturer MaSTherCell Orgenesis Inc. announced the company’s plan to increase its global presence and capabilities by acquiring MaSTherCell, an emerging pioneer in the industrialization of cell-based therapeutics. [Orgenesis Inc. (Marketwire L.P.)] Press Release Arrowhead Acquires Novartis’ RNAi Research and Development Portfolio Arrowhead Research Corporation announced the acquisition of Novartis’ entire RNAi research and development portfolio and associated assets. [Arrowhead Research Corporation (Business Wire)] Press Release FDA Approves Opdivo (Nivolumab) for the Treatment of Patients with Previously Treated Metastatic Squamous Non-Small Cell Lung Cancer Bristol-Myers Squibb Company announced that the U.S. Food and Drug Administration (FDA) has approved Opdivo (nivolumab) injection, for intravenous use, for the treatment of patients with metastatic squamous non-small cell lung cancer with progression on or after platinum-based chemotherapy. [Bristol-Myers Squibb Company] Press Release arGEN-X Expands Preclinical Pipeline with ARGX-115: A Novel Simple Antibody™ for Cancer Immunotherapy arGEN-X N.V. announced that it has exercised its option to exclusively license a first-in-class, preclinical therapeutic antibody candidate, now ARGX-115, to target GARP, a novel immune checkpoint with potential in cancer immunotherapy. [arGEN-X N.V.] Press Release |
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