Cell Therapy News 19.01 January 15, 2018 | |
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TOP STORYThree double-blinded randomized trials compared intramyocardial (IM) autologous-CD34+ cells with IM placebo injections to affect total exercise time, angina frequency, and major adverse cardiac events. [Eur Heart J] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Upon culture in vitro in chondrogenic medium for 21 days, robust cartilage formation was observed in the cell/extracellular matrix (ECM) constructs. Similarly prepared cell/ECM constructs were tested in vivo by subcutaneous implantation into SCID mice. [Acta Biomater] Abstract | Graphical Abstract Amniotic membrane-derived mesenchymal stem cells transplanted into an ischemic rat model of stroke dramatically inhibited the expression of pro-inflammatory cytokines and up-regulated CD200, as compared with the levels in a sham-treated group. [Exp Mol Med] Full Article Human adipose tissue-derived stem cells (ASCs) in low and high concentrations differentiated into vessels when transplanted to mouse peritoneum inside a fibrin matrix, but only high ASC concentrations significantly increased human vessel area 14 days after transplantation. [Hum Reprod] Abstract Researchers present the first adeno-associated virus (AAV) gene therapy experiments in a naturally occurring canine model of globoid cell leukodystrophy that closely recapitulates the clinical disease progression, neuropathological alterations, and biochemical abnormalities observed in human patients. [Hum Gene Ther] Abstract Adipose derived stem cells (ADSCs) were injected into three different tissues and were tracked in vivo with a dual GFP-Luc reporter system. Scientists showed that ADSCs were able to survive up to four months after the engraftment and some of them started showing resident cell tissue phenotype. [J Cell Physiol] Abstract Targeted Repair of Heart Injury by Stem Cells Fused with Platelet Nanovesicles Inspired by the ability of platelets to recruit stem cells to sites of injury on blood vessels, scientists hypothesized that platelets might enhance the vascular delivery of cardiac stem cells (CSCs) to sites of myocardial infarction injury. They showed that CSCs with platelet nanovesicles fused onto their surface membranes express platelet surface markers that are associated with platelet adhesion to injury sites. [Nat Biomed Eng] Abstract | Press Release Intranasal Stem Cell Treatment as a Novel Therapy for Subarachnoid Hemorrhage Intranasal mesenchymal stem cell (MSC) treatment significantly improved sensorimotor and mechano-sensory function at 21 days after subarachnoid hemorrhage. Gray and white matter loss was significantly reduced by MSC treatment and the number of NeuN+ neurons around the lesion increased due to MSC treatment. [Stem Cells Dev] Abstract Interferon-γ Promotes Neuronal Repair by Transplanted Neural Stem Cells in Ischemic Rats The authors investigated whether co-injection of neural stem cells and inteferon-γ can improve therapeutic outcomes in ischemic stroke model. [Stem Cells Dev] Abstract Murine second generation CAR T cells expressing interleukin-12 (IL-12) were capable of eradicating established B cell lymphoma with a long-term survival rate of ~25%. [Mol Ther Oncolytics] Full Article Scientists tested orthotopic pulp regeneration on mini-swine including the use of multi-rooted teeth. Using autologous swine dental pulp stem cells carried by hydrogel and transplanted into the mini-swine root canal space, they observed regeneration of vascularized pulp-like tissue with a layer of newly deposited dentin-like tissue or osteodentin along the canal walls. [Tissue Eng Part C Methods] Abstract | |
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REVIEWSResearchers reviewed the different strategies for optimizing both donor stem cells and the target cardiac microenvironments to enhance the engraftment and efficacy of stem cells, highlighting their clinical translatability and potential limitation. [Stem Cells] Abstract | Full Article The Limited Application of Stem Cells in Medicine: A Review The history of stem cell therapies is one of a limited number of clinical applications despite a vast therapeutic potential. Major breakthroughs in stem cell research have not yet enjoyed clinical success—all stem cell therapies bar hematopoietic stem cell transplantations remain experimental. [Stem Cell Res Ther] Abstract Visit our reviews page to see a complete list of reviews in the cell therapy research field. | |
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SCIENCE NEWSBell Biosystems, Inc. Announces Pre-Clinical Results of Major In Vivo Safety Study Milestone Bell Biosystems, Inc. presented the results of their latest pre-clinical safety study. The study was designed in accordance with USP <151> pyrogenicity guidelines, where the safety of intravascularly injected stem cells labeled for magnetic resonance imaging (MRI) tracking using a high dose of Bell’s Magnelle® brand MRI contrast agent was demonstrated safe in rabbit subjects. [Press release from Bell Biosystems, Inc. (PR Newswire Association LLC.) discussing research presented at the 2018 Biotech Showcase, San Francisco] Press Release | |
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INDUSTRY NEWSSTEMCELL Technologies Inc. has released two product lines for organoid research that will enable scientists to create powerful models for studying human disease in the lab. [STEMCELL Technologies Inc.] Press Release Rocket Pharmaceuticals and Inotek Pharmaceuticals Complete Merger Transaction Rocket Pharmaceuticals, Ltd. announced the completion of its merger with Inotek Pharmaceuticals Corporation. [Rocket Pharmaceuticals, Ltd.] Press Release Alnylam and Sanofi Enter into Strategic Restructuring of RNAi Therapeutics Rare Disease Alliance Alnylam Pharmaceuticals, Inc. and Sanofi announced a strategic restructuring of their RNAi therapeutics alliance to streamline and optimize development and commercialization of certain products for the treatment of rare genetic diseases. [Alnylam Pharmaceuticals, Inc.] Press Release Cell and Gene Therapy Catapult and CombiGene announced that they will be collaborating on a project to develop manufacturing processes for CombiGenes drug candidate CG01, a novel gene therapy for treatment of epilepsy. [Cell and Gene Therapy Catapult] Press Release American CryoStem Statement on the Receipt of a Warning Letter from FDA American CryoStem Corporation issued a statement acknowledging that it has received a warning letter issued by the FDA dated January 3, 2018 relating to its adipose derived stem cell product and its production facilities. This action follows the earlier inspections of the company’s New Jersey facility by the agency between July 17 and July 26, 2017. [American CryoStem Corporation] Press Release CTA Approval for Potentially Pivotal Heartcel™ Phase IIb Trial Celixir announced it has received formal clinical trial application (CTA) approval from the Medicines and Healthcare Products Regulatory Agency to initiate a Phase IIb human clinical trial with its Heartcel™ medicine for the treatment of moderate to severe adult heart failure. [Celixir] Press Release GenSight Biologics announced UK Medicines and Healthcare Regulatory Agency (MHRA) acceptance of the company’s Clinical Trial Application to initiate the PIONEER Phase I/II study of GS030 in patients with retinitis pigmentosa. [GenSight Biologics] Press Release Adaptimmune Therapeutics plc announced initial safety data from its two ongoing pilot studies of SPEAR T-cells targeting MAGE-A10, one in non-small cell lung cancer and a triple tumor study in bladder, melanoma, and head & neck cancers. [Adaptimmune Therapeutics plc] Press Release Adaptimmune Therapeutics plc announced that it has successfully manufactured the first SPEAR T-cells for a patient at its Navy Yard facility in Philadelphia. [Adaptimmune Therapeutics plc] Press Release | |
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POLICY NEWSAt $850,000, Price for New Childhood Blindness Gene Therapy Four Times Too High, Analysis Says The $850,000 list price for a new medicine that treats a genetic form of childhood blindness is about four times too high for the value the drug provides, a nonprofit that studies the cost-effectiveness of new drugs said, though it added that the price of the drug is cost-effective for select patients and with certain assumptions. [STAT News] Editorial South Korean Universities Reach Agreement with Elsevier after Long Standoff After a months-long standoff, a consortium of hundreds of South Korean universities has reached a new deal with scientific publisher Elsevier for access to ScienceDirect, a database containing content from 3,500 academic journals and thousands of electronic books. [ScienceInsider] Editorial Rising Star Appointed UK Science Minister The United Kingdom has gained a new science minister as part of a broader reshuffle of government posts. Sam Gyimah, who moves from the Ministry of Justice, was appointed minister for universities and science, replacing Jo Johnson. [Nature News] Editorial
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REGULATORYFDADetermining Whether to Submit an Abbreviated New Drug Application or 505(b)(2) Application; Draft Guidance for Industry; Availability; Reopening of the Comment Period (FR Doc. No:2018-00405) Notice
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EVENTSNEW World Immunotherapy Congress USA 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Tenure-Track Group Leader Position – Pancreatic Cancer Biology (University of Copenhagen) Postdoctoral Research Fellows – Bioengineering and Nanotechnology (University of Queensland) National Operations Manager – Cellular and Molecular Therapies (NHS Blood & Transplant) Research Associate – Immunology and Gene Therapy (Fred Hutchinson Cancer Research Center) Postdoctoral Associate – Gene Therapy (University of Massachusetts) Postdoctoral Positions – Immunotherapy (University of Houston) Assistant Scientist – Cancer Therapy Research (University of Miami) Postgraduate Positions – Translational Medicine (Qingdao University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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