Cell Therapy News 21.08 March 9, 2020 | |
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TOP STORYChlorotoxin-Directed CAR T for Specific and Effective Targeting of Glioblastoma CAR T cells using chlorotoxin as the targeting domain mediated potent anti-glioblastoma (GBM) activity and efficiently targeted tumors lacking expression of other GBM-associated antigens. [Sci Transl Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers bioprinted a sweat gland (SG)-like matrix to direct the conversion of mesenchymal stem cells (MSCs) into functional sweat glands (SGs) and facilitated SGs recovery in mice. [Sci Adv] Full Article LEM-S401 effectively inhibited the formation of hypertrophic scars in wound-associated dermal fibrosis mouse models, during both the epidermis recovery and tissue remodeling process. [Nanoscale] Abstract | Graphical Abstract Mesenchymal stem cell therapy increased the number of regenerating myofibers and improved fast-twitch and tetanus muscle strength in a mouse model of muscle contusion. [Am J Sports Med] Abstract Higher ascorbic acid content and catalase activity were noted in cerebrospinal fluid (CSF) relative to plasma, whereas superoxide dismutase activity and total antioxidant capacity were higher in plasma relative to CSF. Total antioxidant capacity measured in CSF was greater after bone marrow-derived mesenchymal stem cell transplantations. [J Clin Med] Full Article To validate the antifibrotic effects of the miR-150 secretome, investigators generated in vitro and in vivo models of liver fibrosis by treating human hepatic stellate cells with thioacetamide (TAA) and subcutaneous injection of TAA into mice, respectively. [Exp Mol Med] Full Article Scientists explored the effect of retinal pigment epithelium derived from human-induced pluripotent stem cell on the retina of retinal degeneration 10 mice, which were characterized with progressive photoreceptor death. [Stem Cell Res Ther] Full Article The implanted islet-seeded biomaterial assembled into a solid organoid substructure that reorganized the extracellular matrix compartment and recruited endothelial progenitors for neovascularization. [Sci Rep] Full Article Transplantation of a 3D-Printed Tracheal Graft Combined with iPS Cell-Derived MSCs and Chondrocytes The authors designed an artificial trachea with mechanical properties similar to the native trachea that could enhance the regeneration of tracheal mucosa and cartilage through the optimal combination of a two-layered tubular scaffold and human induced pluripotent stem cell-derived cells. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as Mesenchymal Cell News & ESC & iPSC News. | |
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REVIEWSViral Vectors, Animal Models, and Cellular Targets for Gene Therapy of Cystic Fibrosis Lung Disease Researchers highlight the role next-generation cystic fibrosis (CF) animal models are playing in the preclinical development of gene therapies for CF lung disease and the knowledge gaps in disease pathophysiology these models are attempting to fill. [Hum Gene Ther] Abstract Visit our reviews page to see a complete list of reviews in the cell therapy research field. | |
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INDUSTRY NEWSAmicus Opens New Global Research and Gene Therapy Center of Excellence in Philadelphia Amicus Therapeutics announced the official opening of the company’s Global Research and Gene Therapy Center of Excellence in uCity Square in Philadelphia to advance its industry leading portfolio of rare disease gene therapy programs. [Amicus Therapeutics] Press Release Avectas and CCRM announced they have entered into a collaboration to accelerate the translation of Avectas’ non-viral cell engineering platform into the clinic. [Avectas (PR Newswire Association LLC.)] Press Release GEMoaB announced that it has apheresed the first patient in a Phase IA study with UniCAR-T-CD123, the lead product candidate from its proprietary UniCAR cellular immunotherapy platform. [GEMoaB (PR Newswire Association LLC.)] Press Release OHSU Performs First-Ever CRISPR Gene Editing within Human Body Clinicians with OHSU’s Casey Eye Institute performed the procedure for the BRILLIANCE clinical trial, which seeks to repair mutations in the CEP290 gene that cause a rare form of inherited blindness called Leber congenital amaurosis type 10; also known as LCA10 and CEP290-related retinal dystrophy. [Oregon Health & Science University] Press Release DiscGenics, Inc. announced that it has completed enrollment in its Phase I/II first-in-human US clinical study of IDCT, an allogeneic, injectable discogenic cell therapy for degenerative disc disease. [DiscGenics, Inc.] Press Release | |
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POLICY NEWSNew Trump Rules Aim to Fuel Sharing of Patient Health Records by Smartphone President Trump’s top health care aides said they will finalize federal rules requiring health providers and insurers to make health records available to patients in an easily accessible electronic format, a policy shift aimed at fueling broader efforts to use patient data to develop new software tools and services. [STAT News] Editorial
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EVENTSNEW First International STEMNET Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Cancer Immunotherapy (The University of Texas MD Anderson Cancer Center) Sr Associate Scientist – Autoimmunity and Tumor Immunotherapy (Amgen) Research Associate – Stem Cell and Gene Therapy Program (Fred Hutchinson Cancer Research Center) Postdoctoral Researcher – Cell Therapies for Cancer (Technical University of Denmark) Postdoctoral Fellow – Inflammation and Cancer (University Hospital of Erlangen) Lecturer – Clinical Pharmacology (University of Bristol) Research Assistant – Organoid Modeling for Stem Cell Therapies (Boston Children’s Hospital) Postdoctoral Fellow – Cancer Research (BC Cancer) Research Assistant – Cancer Research (BC Cancer) Postdoctoral Fellow – Single Cell Genomics (BC Cancer) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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