Cell Therapy News Volume 21.22 | Jun 22 2020

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    2020-22-06 | CTN 21.22

    Cell Therapy News by STEMCELL Technologies
    Vol. 21.22 – 22 June, 2020
    TOP STORY

    Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

    Intravenous delivery of immunity- and matrix-regulatory cells, derived from human embryonic stem cells, inhibited both pulmonary inflammation and fibrosis in mouse models of lung injury, and significantly improved the survival rate of the recipient mice in a dose-dependent manner, likely through paracrine regulatory mechanisms.
    [Cell Research]

    Full Article

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    Engraftment Kinetics after Transplantation of Double Unit Cord Blood Grafts Combined with Haplo-Identical CD34+ Cells without Antithymocyte Globulin

    Scientists investigated adding haplo-identical CD34+ cells to double unit cord blood (CB) grafts to facilitate early haplo-identical donor-derived neutrophil recovery prior to CB engraftment.
    [Leukemia]

    Abstract

    Human Gingiva-Derived Mesenchymal Stem Cells Are Therapeutic in Lupus Nephritis through Targeting of CD39-CD73 Signaling Pathway

    Investigators demonstrated that the adoptive transfer of gingiva derived mesenchymal stem cells homes to and maintains in the kidney and had a robust therapeutic effect in a spontaneous lupus nephritis model.
    [Journal of Autoimmunity]

    Abstract

    Bone Regeneration Capacities of Alveolar Bone Mesenchymal Stem Cells Sheet in Rabbit Calvarial Bone Defect

    Scientists compared the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone and iliac bone in vitro and in vivo.
    [Journal of Tissue Engineering]

    Full Article

    Effect of Amniotic Fluid Stem Cell Transplantation on the Recovery of Bladder Dysfunction in Spinal Cord-Injured Rats

    The effects of human amniotic fluid stem cell transplantation on bladder function and molecular changes in spinal cord-injured rats were investigated.
    [Scientific Reports]

    Full Article

    Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Pre-Conditioned Cardiosphere Derived Cells

    Scientists enhanced the effect of cardiosphere-derived cells with APOSEC preconditioning (apoCDC), and investigated the reparative effect in a translational pig model of reperfused MI.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    Anti-Relapse Effects of Donor Natural Killer Cells and IL-2 Gene Modification on Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia

    The authors investigated whether donor natural killer cells and interleukin-2 gene modification exerted anti-relapse effects on allogeneic hematopoietic stem-cell transplantation after establishing a mouse model of acute leukemia.
    [Cancer Biomarkers]

    Abstract

    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    Regenerative Potential of Wharton’s Jelly‐Derived Mesenchymal Stem Cells: A New Horizon of Stem Cell Therapy

    The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of Wharton’s jelly‐derived mesenchymal stem cells in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
    [Journal of Cellular Physiology]

    Abstract

    INDUSTRY AND POLICY NEWS

    UCLA Receives Nearly $14 Million from NIH to Investigate Gene Therapy to Combat HIV

    UCLA researchers and colleagues have received a $13.65 million grant from the National Institutes of Health (NIH) to investigate and further develop an immunotherapy known as CAR T, which uses genetically modified stem cells to target and destroy HIV.
    [University of California, Los Angeles]

    Press Release

    Ovid Therapeutics Announces Strategic Research Collaboration Focused on Accelerating the Development of New Treatments for Rare Neurological Diseases

    Ovid Therapeutics Inc. announced a strategic research collaboration with Columbia University Irving Medical Center researchers to advance genetic based therapies for a range of rare neurological conditions, complementary to Ovid’s current pipeline.
    [Ovid Therapeutics Inc.]

    Press Release

    City of Hope Signs Licensing Agreement with Scopus BioPharma Inc. to Develop Novel, Targeted Immuno-Oncology Gene Therapy

    City of Hope have signed an exclusive, worldwide licensing agreement with Scopus BioPharma Inc. Scopus will further develop and plans to commercialize a City of Hope first-in-class, targeted immuno-oncology gene therapy.
    [City of Hope]

    Press Release

    FEATURED EVENT

    International Society for Stem Cell Research (ISSCR) Virtual Annual Meeting 2020

    2020-06-23 – 2020-06-27
    Virtual

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    JOB OPPORTUNITIES

    Scientific Project Manager – Neurofibromatosis Type 1 Gene Therapy

    Gilbert Family Foundation – Detroit, Michigan, United States

    Postdoctoral Fellow – Immune and Stem Cell Engineering

    Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States

    Faculty Positions – Regenerative Medicine

    Guangzhou Regenerative Medicine and Health Guangdong Laboratory – Guangzhou, China

    Chair – Bioengineering

    University of Washington – Seattle, Washington, United States

    Lab Director – Cancer Immunotherapy

    Vrije Universiteit Brussels – Brussels, Belgium

    Principal Scientist – Human iPSC Gene Engineering

    Empyrean Therapeutics Ltd – Cambridge, United Kingdom

    Postdoctoral Position – RNA Editing and Immunotherapy

    University of Chicago – Chicago, Ilinois, United States

    Postdoctoral Fellow – CRISPR Research

    Boston Children’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Fellow – Cancer Adoptive Cell Immunotherapy

    Wake Forest School of Medicine – Winston Salem, North Carolina, United States

    Postdoctoral Position – CRISPR/Cas Genetic Engineering

    Aarhus University – Aarhus C, Denmark

    Professor Positions – Biomedical Sciences

    The Chinese University of Hong Kong – Hong Kong, China

    > See All Jobs

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