 | | Vol. 21.27 – 27 July, 2020 |
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| Analysis of clinical transgenic adoptive cell therapy products in vivo revealed that despite strong persistence of the transgenic T-cell receptor DNA sequence over time, its expression was profoundly decreased over time at the RNA and protein levels.
[Cancer Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using a highly novel gene therapy approach in a canine, rapid atrial pacing model of atrial fibrillation, researchers demonstrated that NADPH oxidase 2 generated oxidative injury.
[Circulation] |
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| By conducting flow cytometry of the cervical cells, scientists found that poly PBAE-GFP-NPs-mMMT gel was more efficient than PBAE-GFP-NPs-HTT gel in delivering exogenous DNA intravaginally.
[Ebiomedicine] |
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| Investigators tested if knockdown of USP10 with a USP10-targeting sdRNA reduced scarring after wounding a rabbit cornea in vivo.
[Molecular Therapy-Nucleic Acids] |
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| The authors investigated therapeutic efficiency and potential mechanism of probucol combined with mesenchymal stem cells.
[Stem Cell Research & Therapy] |
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| Scientists investigated the therapeutic potential of neural precursor cells derived from human HLA‐homozygous induced pluripotent stem cells following intracerebral transplantation into a rodent model of middle cerebral artery occlusion.
[Cell Proliferation] |
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| Researchers present a simple approach for islet preconditioning that uses the antibiotic mitomycin C, which has antitumor activity, to reduce islet immunogenicity and prevent proinflammatory events in an intraportal islet transplantation model.
[Scientific Reports] |
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| The authors performed cellular, kinematic, physiological, and anatomical analyses, either in vitro or in vivo, to comprehensively evaluate the safety and efficacy associated with subarachnoid transplantation of human umbilical cord mesenchymal stem cells in rats with subacute incomplete spinal cord injury.
[Experimental Cell Research] |
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| Investigators determined the ability of the R-GSIK scaffold in supporting the effects of mesenchymal stem cells on motor function activity and inflammatory responses in an experimental traumatic brain injury model.
[Cell and Tissue Research] |
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| Researchers discuss innovative developments in the CAR T-cell therapy field that benefited from evaluation in humanized mice, illustrated by multiple examples.
[Cancers] |
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| Sarepta Therapeutics, Inc. announced that the FDA has granted Fast Track designation to SRP-9001. SRP-9001 is an investigational gene transfer therapy intended to deliver its micro-dystrophin-encoding gene to muscle tissue for the targeted production of the micro-dystrophin protein.
[Sarepta Therapeutics, Inc.] |
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| Kite announced that the FDA has granted accelerated approval to Tecartus™, the first and only approved chimeric antigen receptor T cell therapy for the treatment of adult patients with relapsed or refractory mantle cell lymphoma.
[Gilead Sciences, Inc.] |
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| The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider] |
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| August 19 – August 21
Virtual |
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| | Nanyang Technological University – Singapore, Singapore |
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| | Genezen Laboratories – Indianapolis, Indiana, United States |
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| | Genezen Laboratories – Indianapolis, Indiana, United States |
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| | Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States |
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| | Guangzhou Regenerative Medicine and Health Guangdong Laboratory – Guangzhou, China |
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Cancer Stem Cell News
Cell Therapy News
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Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
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Hepatic Cell News
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Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
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