 | | Vol. 21.40 – 16 November, 2020 |
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| To access human endocardial cells, investigators generated a human pluripotent stem cell-derived endothelial population that displayed many characteristics of endocardium, including expression of the cohort of genes that identified this lineage in vivo, the capacity to induce a trabecular fate in immature cardiomyocytes in vitro, and the ability to undergo endothelial-to-mesenchymal transition.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| An anti‐inflammatory gene therapy nanoparticle targeted to VCAM‐1, a protein overexpressed by inflamed endothelial cells located within atherosclerotic plaque, was developed.
[Advanced Therapeutics] |
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| In vivo, researchers found that mice given CAR T cells with only a PYAP CD28 endodomain had a significant survival advantage, with 100% of mice alive after 62 days compared to 50% for mice with an unmutated endodomain.
[Cancer Immunology Research] |
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| Scientists explored the therapeutic efficacy of human induced pluripotent stem cell (iPSC)‐derived endothelial cell and iPSC‐derived smooth muscle cell in peripheral artery disease model.
[Stem Cells Translational Medicine] |
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| Investigators designed and tested new endothelial differentiation media with a fully defined composition using standard basal culture media supplemented with a mixture of B27, heparin and growth factors, including VEGF-A165 at different concentrations.
[Biomedicines] |
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| Scientists report the outcome of 68 patients with advanced peripheral T-cell lymphoma receiving transplantation from haploidentical or from conventional donors. The four-year overall survival, progession free survival, two-year cumulative incidence of relapse and two-year GVHD and relapse free survival was 75%, 70%, 21%, and 51%, respectively.
[Bone Marrow Transplantation] |
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| The authors evaluated the effects of the number of implanted bone-marrow mononuclear cells on clinical outcomes in atherosclerotic peripheral arterial disease patients with critical limb ischemia who underwent cell therapy.
[Scientific Reports] |
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| Primary co-cultures of dental pulp stem cell (DPSC) and rigeminal ganglion neuronal cells (TGNC) were established to evaluate the paracrine effects of DPSC. In comparison, nerve growth factor was used to evaluate its neurotrophic and neuritogenic effect on TGNC.
[Scientific Reports] |
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| The authors identified the efficacy of ruxolitinib in human leukocyte antigen haploidentical hematopoietic stem cell transplantation recipients with multidrug-resistant-graft-versus-host disease.
[Annals of Hematology] |
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| Scientists review the latest reports regarding blockade of CAR T cell exhaustion and senescence with a particular focus on the exhaustion-inducing pathways. Subsequently, they describe what potential these latest insights offer for boosting the potency of adoptive cell transfer therapies involving CAR T cells.
[Oncogene] |
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| Vor Biopharma announced an exclusive licensing agreement with the National Cancer Institute, part of the National Institutes of Health, for intellectual property related to a clinical-stage anti-CD33 chimeric antigen receptor T-cell therapy candidate.
[Vor Biopharma] |
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| Xencor, MorphoSys AG and Incyte announced a clinical collaboration to investigate the combination of tafasitamab, plamotamab and lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), first-line DLBCL, and relapsed or refractory follicular lymphoma.
[Xencor] |
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| Homology Medicines, Inc. announced the presentation of positive data from the dose-escalation portion of the Phase I/II gene therapy pheNIX clinical trial for adults with phenylketonuria.
[Homology Medicines, Inc. (Globe Newswire, Inc.)] |
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| July 22 – July 23, 2021
Berlin, Germany |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | LMU University Hospital Munich – Munich, Germany |
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| | EnaraBio – Oxford, England, United Kingdom |
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| | GlaxoSmithKline – Stevenage, United Kingdom |
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| | Nanyang Technological University – Singapore, Singapore |
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Cancer Stem Cell News
Cell Therapy News
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Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
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Human Immunology News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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