Cell Therapy News Volume 22.03 | Jan 25 2021

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    Justin.choi
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    CTN 22.03 | Jan 25 2021


    Cell Therapy News by STEMCELL Technologies
    Vol. 22.03 – 25 January, 2021
    TOP STORY

    A
    CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Non-Essential Modes of Oncogenic Transformation

    CRISPR/Cas9-mediated ARID1A knockout in primary TP53-/- human gastric organoids induced morphologic dysplasia, tumorigenicity and mucinous differentiation.
    [Cancer Discovery]

    Abstract

    Dr. Jackie Damen discusses why the CFU assay should be a vital part of your cell therapy workflow in this on-demand webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Preclinical
    Assessment of the Efficacy and Specificity of GD2-B7H3 SynNotch CAR-T in Metastatic Neuroblastoma

    Researchers found that murine GD2 CAR-T cells, specific for the tumor-associated antigen GD2, induce fatal neurotoxicity in a costimulatory domain-dependent manner.
    [Nature Communications]

    Full Article

    Universal
    Toxin-Based Selection for Precise Genome Engineering in Human Cells

    Scientists screened for mutations in the receptor for Diphtheria Toxin (DT) which protected human cells from DT.
    [Nature Communications]

    Full Article

    Generation
    of HIV-Resistant Cells with a Single-Domain Antibody: Implications for HIV-1 Gene Therapy

    Glycosylphosphatidylinositol-anchored m36.4, a single-domain antibody targeting the coreceptor-binding site of gp120, was constructed with a lentiviral vector. Investigators verified that m36.4 was efficiently expressed on the plasma membrane of transduced TZM-bl cells and targeted lipid raft sites without affecting the expression of HIV receptors.
    [Cellular & Molecular Immunology]

    Full Article

    Long-Term
    Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

    To determine whether autologous hematopoietic stem cell transplantation was able to induce durable disease remission in people with multiple sclerosis (MS), researchers analyzed the long-term outcomes after transplant in a large cohort of MS patients.
    [Neurology]

    Abstract

    Nanoparticle T-Cell Engagers as a Modular Platform for Cancer Immunotherapy

    Investigators developed nanoparticle-based bispecific T-cell engagers, which were liposomes decorated with anti-CD3 monoclonal antibodies (mAbs) targeting T cells, and mAbs targeting the cancer antigen.
    [Leukemia]

    Full Article

    Mesenchymal
    Stem Cells Ameliorate Lipid Metabolism through Reducing Mitochondrial Damage of Hepatocytes in the Treatment of Post-Hepatectomy Liver Failure

    Scientists found that there were some subtle connections between mesenchymal stem cells and liver lipid metabolism in the post-hepatectomy liver failure model.
    [Cell Death & Disease]

    Full Article

    Survival of Salivary Gland Cancer Stem Cells Requires mTOR Signaling

    The authors tested the hypothesis that mucoepidermoid carcinoma (MEC) cancer stem cells were sensitive to therapeutic inhibition of mTOR. They report a correlation between the long-term clinical outcomes of 17 MEC patients and the intratumoral expression of p-mTOR and p-S6K1.
    [Cell Death & Disease]

    Full Article

    Comparative
    Analysis on the Anti-Inflammatory/Immune Effect of Mesenchymal Stem Cell Therapy for the Treatment of Pulmonary Arterial Hypertension

    Researchers compared the treatment effects of adipose tissue-, bone marrow-, and umbilical cord blood-derived mesenchymal stem cells in the rat monocrotaline-induced pulmonary hypertension model.
    [Scientific Reports]

    Full Article

    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    REVIEWS

    Advances
    in the Development of Personalized Neoantigen-Based Therapeutic Cancer Vaccines

    Scientists provide an overview of the complex process that is necessary to generate a personalized neoantigen vaccine, review the types of vaccine-induced T cells that are found within tumours and outline strategies to enhance the T cell responses.
    [Nature Reviews Clinical Oncology]

    Full Article

    Recent Advances and Discoveries in the Mechanisms and Functions of CAR T Cells

    The authors discuss the major advances and changes made over the past three years to our understanding of chimeric antigen receptor T cell efficacy and safety.
    [Nature Reviews Cancer]

    Abstract

    CRISPR Technologies and the Search for the PAM-Free Nuclease

    Investigators review ongoing efforts toward realizing protospacer adjacent motif-free nucleases through natural ortholog mining and protein engineering.
    [Nature Communications]

    Full Article

    INDUSTRY AND POLICY NEWS

    Precision BioSciences Announces FDA Accepts IND for PBCAR19B, a Next-Generation, Stealth Cell, CD19 Allogeneic CAR T Candidate for Non-Hodgkin Lymphoma

    Precision BioSciences, Inc. announced that the FDA has accepted the Investigational New Drug application for PBCAR19B, a next-generation, stealth cell, CD19 product candidate for patients with relapsed/refractory Non-Hodgkin Lymphoma.
    [Precision BioSciences, Inc. (Globe Newswire, Inc.)]

    Press Release

    Sarepta Therapeutics and Genevant Sciences Announce Research Collaboration for Lipid Nanoparticle-Based Gene Editing Therapeutics

    Sarepta Therapeutics, Inc. and Genevant Sciences announced a research collaboration and option agreement for the delivery of LNP-gene editing therapeutics in Sarepta’s pipeline for neuromuscular diseases.
    [Sarepta Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    The 3rd
    UK Cellular Microbiology Network

    March 1 – 2, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Retinal Cell Therapy Development

    University of British Columbia – Vancouver, British Columbia, Canada


    Postdoctoral Fellow – T Cell Immunology and Transplantation

    Stanford School of Medicine – Stanford, California, United States

    Postdoctoral Position – Gene Regulation and Neuroinflammation

    National Institutes of Health – Bethesda, Maryland, United States


    Postdoctoral Fellow – Cancer Genetics and Immunology

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Experimental Genetics Researcher – IBS, and the Immune/Microbiome/Endothelial Axis

    University of California San Francisco – San Francisco, California, United States

    > See All Jobs

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