Cell Therapy News Volume 22.12 | Apr 5 2021

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    CTN 22.12 | Apr 5 2021


    Cell Therapy News by STEMCELL Technologies
    Vol. 22.12 – 5 April, 2021
    TOP STORY

    Transient Rest Restores Functionality in Exhausted CAR-T Cells through Epigenetic Remodeling

    Using murine xenograft models and an in vitro model wherein tonic CAR signaling induced hallmark features of exhaustion, researchers tested the effect of transient cessation of receptor signaling, or rest, on the development and maintenance of exhaustion.
    [Science]

    Abstract

    Dr. Jackie Damen discusses why the CFU assay should be a vital part of your cell therapy workflow in this on-demand webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    A Cross-Talk between CAR T Cell Subsets and the Tumor Microenvironment Is Essential for Sustained Cytotoxic Activity

    Researchers report an essential cross-talk between CAR T cell subsets and the tumor microenvironment for tumor control in an immunocompetent mouse B cell lymphoma model of anti-CD19 CAR T cell therapy.
    [Science Immunology]

    Abstract

    Receptor-Ligand Supplementation via a Self-Cleaving 2A Peptide–Based Gene Therapy Promotes CNS Axonal Transport with Functional Recovery

    The authors offered evidence that combined overexpression of both brain-derived neurotrophic factor and its receptor, tropomyosin receptor kinase B, was more effective in stimulating axonal transport than either receptor administration or ligand administration alone.
    [Science Advances]

    Full Article

    The Deubiquitinase Usp9x Regulates PRC2-Mediated Chromatin Reprogramming during Mouse Development

    Scientists report a post-translational mechanism that destabilized Polycomb Repressive Complex 2 (PRC2) to constrict H3K27me3 during lineage commitment.
    [Nature Communications]

    Full Article

    Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Crest Cells for Corneal Endothelial Regeneration

    Transplantation of the hiPSC-derived neural crest cells rapidly restored rabbit corneal thickness and clarity. However, the long-term recovery efficacy was impaired by the improper maturation, senescence, and endothelial-mesenchymal transition of the transplanted cells.
    [Stem Cell Research & Therapy]

    Full Article

    Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy

    Researchers identified two markers for myogenic cell purification: CDH13, which purified most of the myogenic cells, and FGFR4, which purified a subset of muscle progenitor cells.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Synapsin-Caveolin-1 Gene Therapy Preserves Neuronal and Synaptic Morphology and Prevents Neurodegeneration in a Mouse Model of Alzheimer’s Disease

    Scientists indicated that SynCav1 gene therapy may be an option for Alzheimer’s disease and potentially in other forms of neurodegeneration caused by unknown etiology.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    Efficacy of Topical and Systemic Transplantation of Mesenchymal Stem Cells in a Rat Model of Diabetic Ischemic Wounds

    The authors compared the effects of topical and systemic transplantation mesenchymal stem cells on diabetic ischemic wound healing and explored the underlying mechanisms.
    [Stem Cell Research & Therapy]

    Full Article

    Efficient CRISPR/Cas9 Based Genome Editing of β-Globin Gene on Erythroid Cells from Homozygous β039-Thalassemia Patients

    By CRISPR/Cas9 gene editing, scientists present the correction of the β039-thalassemia mutation, one of the most frequent in the Mediterranean area.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    Lotus-Root-Shaped Cell-Encapsulated Construct as a Retrieval Graft for Long-Term Transplantation of Human iPSC-Derived β-Cells

    Researchers developed a lotus-root-shaped cell-encapsulated construct as a graft that could be retrieved after long-term human-stem-cell-derived pancreatic beta cell transplantation.
    [iScience]

    Full ArticleGraphical Abstract

    Explore scientific events this April with the Science Events Calendar.
    REVIEWS

    Enhancing CAR-T Cell Efficacy in Solid Tumors by Targeting the Tumor Microenvironment

    The authors summarize the inhibitory factors that affect the function of CAR-T cells in tumor microenvironment and discuss approaches to improve CAR-T cell efficacy for solid tumor treatment by targeting those barriers.
    [Cellular & Molecular Immunology]

    Abstract

    Scaffold-Free Cell-Based Tissue Engineering Therapies: Advances, Shortfalls and Forecast

    Scientists critically discuss advancements and shortfalls of scaffold-free cell-based tissue engineering strategies, along with pioneering concepts that have the potential to transform regenerative and reparative medicine.
    [NPJ Regenerative Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    Turning Point Therapeutics Announces Initial Clinical Data from Phase I/II SWORD-1 Study of RET Inhibitor TPX-0046

    Turning Point Therapeutics, Inc. report initial clinical data from the ongoing Phase I/II SWORD-1 study of its RET inhibitor drug candidate, TPX-0046.
    [Turning Point Therapeutics, Inc. (Globe Newswire, Inc.)]

    Press Release

    Kite Submits Supplemental Biologics License Application to US Food and Drug Administration for Tecartus® in Adult Patients with Relapsed or Refractory Acute Lymphoblastic Leukemia

    Kite announced that it has submitted a supplemental Biologics License Application to FDA for Tecartus® for the treatment of adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).
    [Kite (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    Wisconsin Stem Cell Symposium: The Single Cell Revolution in Stem Cells

    April 14, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Lab Scientist – Tissue and Cellular Therapy

    The University of Iowa – Iowa City, Iowa, United States

    Assistant Professor – Hematology

    University of Washington – Seattle, Washington, United States

    Postdoctoral Position – Gene and Cell Therapy Development for Treatment of Primary Immune Deficiencies

    NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States

    Stem Cell Core Director – Stem Cell Research

    Gladstone Institute – San Francisco, California, United States

    Research Fellow – RNA Biology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    > See All Jobs

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