Cord Blood News 10.01 January 11, 2018 | |
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TOP STORYPeptidomimetic Blockade of MYB in Acute Myeloid Leukemia Using structure-guided molecular design, the authors developed a peptidomimetic inhibitor MYBMIM that interferes with the assembly of the molecular MYB:CBP/P300 complex and rapidly accumulates in the nuclei of acute myeloid leukemia cells. MYBMIM impeded leukemia growth and extended survival of immunodeficient mice engrafted with primary patient-derived MLL-rearranged leukemia cells. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists found that two transcription factors, MYCN and SOX17, induce and indefinitely expand in culture precursors of human arterial endothelial cells (expandable arterial endothelial precursors [eAEPs]). The eAEPs are derived from CD34+ cells found in umbilical cord blood or adult bone marrow. [Stem Cell Reports] Full Article | Press Release Researchers demonstrated that distinct mesenchymal subpopulations co-emerge from mesoderm during human pluripotent stem cell differentiation. Despite co-expression of common mesenchymal markers, a subset of cells defined as CD146hiCD73hi expressed genes associated with the hematopoietic stem/progenitor cell (HSPC) niche and supported the maintenance of functional HSPCs ex vivo, while CD146loCD73lo cells supported differentiation. [Stem Cell Reports] Full Article Investigators showed that paracrine action of human umbilical cord blood-derived-MSCs (hUCB-MSCs) protects the hippocampus from synaptic-density loss in in vitro and in vivo Alzheimer’s disease models. Treatment with exogenous recombinant thrombospondin-1 or co-cultures with hUCB-MSCs significantly increased expression of synaptic-density markers, such as synaptophysin and post-synaptic density protein-95 in amyloid beta-42-treated mouse hippocampal neurons. [Sci Rep] Full Article The authors used in utero hematopoietic cell transplantation (IUHCT) of human CD34+ cells in NSG mice to create a reproducible mouse model to study stem cell engraftment, differentiation, and systemic repopulation after IUHCT. [Blood Adv] Full Article Scientists evaluated the therapeutic potential of intravenous transplantation of human umbilical cord blood mononuclear cells transduced with adenoviral vectors overexpressing nerve growth factor for the treatment of Alzheimer’s disease in an APP/PS1 transgenic mice model. [BioNanoScience] Abstract | |
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REVIEWSThe Limited Application of Stem Cells in Medicine: A Review Major breakthroughs in stem cell research have not yet enjoyed clinical success—all stem cell therapies bar hematopoietic stem cell transplantations remain experimental. The authors conclude that the failure of such therapies to achieve clinical translation stems from the polarizing effect of the ethical debate around their use. [Stem Cell Res Ther] Full Article Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSHelsinn and MEI Pharma, Inc. announced that the European Medicines Agency has granted Orphan Drug Designation to pracinostat, an investigational drug candidate currently in a Phase III study in combination with azacitidine for the treatment of AML in adult patients unfit to induction chemotherapy. [MEI Pharma Inc.] Press Release GenCure opened the first phase of a new biomanufacturing center designed to address a critical roadblock slowing the advancement of cellular therapies and the field of regenerative medicine: A lack of access to large-scale stem cell manufacturing and support services required for current Good Manufacturing Process-compliant production of biologics for use in human clinical trials and commercial manufacturing. [GenCure (GlobeNewswire, Inc.)] Press Release | |
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POLICY NEWSRising Star Appointed UK Science Minister The United Kingdom has gained a new science minister as part of a broader reshuffle of government posts. Sam Gyimah, who moves from the Ministry of Justice, was appointed minister for universities and science, replacing Jo Johnson. [Nature News] Editorial Faced with Public Pressure, Research Institutions Step Up Reporting of Clinical Trial Results The reporting of clinical trial results to a public database — mandated by a ten-year-old federal law — has improved sharply in the last two years, with universities and other nonprofit research centers leading the way. [STAT News] Editorial
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EVENTSNEW Annual Meeting of the Israel Stem Cell Society 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Fellow – Pediatric Cancer and Zebrafish Models (Massachusetts General Hospital) Postdoctoral Fellow – Hematopoietic Stem Cell Biology (University of Colorado, Anschutz) Investigator – Stem Cells (BloodCenter of Wisconsin) PhD Student Position – Leukemia (RWTH Aachen University) Research Assistant – Mouse Handling (The University of Texas MD Anderson Cancer Center) Research Assistant – Flow Cytometry (The University of Texas MD Anderson Cancer Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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