Cord Blood News 10.02 January 18, 2018 | |
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TOP STORYResearchers examined immunological mechanisms determining the fate of infused MSC and the immunomodulatory response associated with it. Tracking viable and dead human umbilical cord MSC (ucMSC) in mice using Qtracker beads and Hoechst33342 revealed that viable ucMSC were present in the lungs immediately after infusion. [Stem Cells] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists investigated the expression profile of amniotic membrane-derived MSCs cultured under hypoxic conditions and observed interesting expression changes in various genes involved in immune regulation. CD200, an anti-inflammatory factor and positive regulator of transforming growth factor-beta, was more highly expressed under hypoxic conditions than normoxic conditions. [Exp Mol Med] Full Article Amniotic Fluid Stem Cell Exosomes: Therapeutic Perspective Morphology, phenotype, and protein content of exosomes released into amniotic fluid in vivo and from amniotic fluid stem cells (AFSCs) during in vitro culture were examined. The authors found that AFSC-derived exosomes present different molecules than amniotic fluid ones, some of them involved in immunomodulation, such transforming growth factor beta and hepatic growth factors. [Biofactors] Abstract Culturing 3D-expanded human placental-derived adherent stromal cells in the presence of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) transiently upregulated the secretion of numerous anti-proliferative, anti-angiogenic and pro-inflammatory cytokines. [Sci Rep] Full Article Investigators developed a new activator for bone marrow-MSCs using human umbilical cord extracts, Wharton’s jelly extract supernatant, which improved cell proliferation, mobilization and suppressive effects on activated osteoclasts in ovariectomy-MSCs. [Sci Rep] Full Article Scientists investigated whether inhibition of autophagy could weaken or block the function of human umbilical cord MSCs (huMSCs) through in vitro and in vivo experiments. They demonstrated that regulation of autophagy can affect huMSC migration and their neuronal differentiation. [Stem Cell Res Ther] Full Article Researchers evaluated the effect of human umbilical cord-derived MSC (hucMSC) conditioned medium (CM) on renal tubulointerstitial inflammation and fibrosis. hucMSC-CM reduced extracellular matrix deposition and inflammatory cell infiltration as well as release of inflammatory factors in unilateral ureteral obstruction-induced renal fibrosis. [Stem Cell Res Ther] Full Article EDAG Promotes the Expansion and Survival of Human CD34+ Cells Using ex vivo culture and hematopoietic stem cell transplantation models, the authors report that erythroid differentiation-associated gene (EDAG) enhanced the proliferative potential of human cord blood CD34+ cells, increases survival, prevents cell apoptosis and promotes their repopulating capacity. [PLoS One] Full Article Investigators expanded cord blood mononuclear cells (CB MNCs) in co-culture with human adipose tissue-derived stromal cells (ASCs) to enrich hematopoietic stem and progenitor cells (HSPCs) and describe phenotypic features of newly formed hematopoietic populations. CB MNC expansion in the presence of ASCs provided the generation of both lineage committed lymphoid progenitors and CD34+/CD133– primitive HSPCs. [Cell Tissue Res] Abstract | |
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REVIEWSThe Rocky Road to Personalized Medicine in Acute Myeloid Leukemia The authors describe current standard and investigational therapeutic strategies with a focus on targeted agents and highlight potential tools that might facilitate the development of targeted therapies for this fatal disease. [J Cell Mol Med] Full Article Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSAmerican CryoStem Statement on the Receipt of a Warning Letter from FDA American CryoStem Corporation issued a statement acknowledging that it has received a warning letter issued by the FDA dated January 3, 2018 relating to its adipose derived stem cell product and its production facilities. This action follows the earlier inspections of the company’s New Jersey facility by the agency between July 17 and July 26, 2017. [American CryoStem Corporation] Press Release Cellect Biotechnology Ltd. announced that it has signed an agreement with the Hadassah Medical Center to conduct clinical trials on cancer patients in Cellect’s ongoing Phase I/II study. Furthermore, Cellect received approval from the independent Data and Safety Monitoring Board (DSMB) to escalate ApoGraft™ FasL protein dosage to 25 ng/ml and enroll three additional patients for the clinical trial. [Cellect Biotechnology Ltd. (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSWhat a US Government Shutdown Would Mean for Science The National Institutes of Health would stop processing grants, but astronauts in space would keep working. [Nature News] Editorial In Trump’s First Year, Science Advice Sees a Marked Decline Since U.S. President Donald Trump took office, expert panels that provide key federal agencies with science advice have had fewer members and met less often than at any time since 1997, when the government started tracking such numbers, a new analysis concludes. [ScienceInsider] Editorial
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EVENTSNEW 2018 Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Tumor Immunology (University of Maryland) Research Fellow – Pediatric Cancer and Zebrafish Models (Massachusetts General Hospital) Postdoctoral Scientists and Research Technologists – Hematopoiesis and Leukemogenesis (City of Hope) Postdoctoral Fellow – Hematopoietic Stem Cell Biology (University of Colorado, Anschutz) PhD Student Position – Leukemia (RWTH Aachen University) Research Assistant – Mouse Handling (The University of Texas MD Anderson Cancer Center) Research Assistant – Flow Cytometry (The University of Texas MD Anderson Cancer Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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