Cord Blood News 10.06 February 15, 2018 | |
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TOP STORYThe authors demonstrated that human umbilical cord MSCs (hUCMSCs) dramatically increased the growth of lung adenocarcinoma (LUAD) cancer cells in a xenograft tumor model. They observed that hUCMSC-derived extracellular vesicles contribute to the hUCMSC-promoted LUAD cell growth through a direct effect on LUAD cells. [Cell Death Dis] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists compared the 3D spheroid-cultured human umbilical derived MSCs (3D UC-MSCs) with 2D-cultured UC-MSCs (2D UC-MSCs) on treating hepatic ischemia-reperfusion injury. The RNA sequencing data showed that suppression of cell mitosis, response to hypoxia, inflammation, and angiogenesis were the top genetic changes in 3D UC-MSCs compared with 2D UC-MSCs. [Sci Rep] Full Article Umbilical cord-derived MSC transplantation contributed to the repair of endometrial injury and restoration of fertility, likely through the suppression of excessive fibrosis and inflammation, and enhancement of endometrial cell proliferation and vascular remodeling. [Stem Cell Res Ther] Full Article Induced Pluripotent Stem Cells Derived from Human Amnion in Chemically Defined Conditions Researchers describe episomal reprogramming of MSCs from the human amnion to pluripotency (AM-iPSC) in chemically defined conditions. The AM-iPSC expressed markers of embryonic stem cells, readily formed teratomas with tissues of all three germ layers present and had a normal karyotype after around 40 passages in culture. [Cell Cycle] Abstract Recovery of lymphocyte subsets, thymopoiesis, and its association with severe infections and clinical outcome was assessed in a group of 55 recipients of a double umbilical cord blood stem cell transplantation anti-thymocyte globulin free reduced intensity conditioning regimen. [Bone Marrow Transplant] Abstract Investigators characterized equine umbilical cord blood-derived MSCs (eUCB-MSCs) and evaluated their potential for chondrocyte differentiation for use in cartilage repair therapy. They showed that isolated eUCB-MSCs had high proliferative capacity and differentiated easily into osteoblasts and chondrocytes, but not into adipocytes. [Int J Mol Sci] Full Article Umbilical cord (UC) explants were evaluated using a plating and scoring system accounting for cell attachment and proliferation. Explant scores for fresh and cryopreserved-then-thawed tissue from the same UC were compared. Metabolic activity of composite UC tissue was also assayed after exposure of the tissue to conditions anticipated to affect UC quality and compared with explant scores within the same UC. [Cytotherapy] Full Article MSCs and extracellular vesicles (EVs) had similar miRNA expression profiles, with the exception of a small number of selectively enriched miRNAs. GO analysis indicated that, unlike MSCs, the target genes of EV-enriched miRNAs were associated with calcium channel regulation and cell junction activities, which may indicate that MSC and EVs have different regulatory properties. [Kidney Blood Press Res] Full Article Scientists investigated the effect of human amnion-derived MSCs (HAMSCs) on human adipose-derived stem cells (HASCs) by a transwell co-culture system. HAMSCs promoted proliferation, osteogenic differentiation, angiogenic potential and adiponectin secretion of HASCs. [BMB Rep] Abstract | |
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REVIEWSSeveral studies have focused on umbilical cord (UC)-derived MSCs due to their potential therapeutic effects in a cluster of diseases. However, there has been no bibliometric analysis evaluating the evolution in UC-MSC research. Therefore, this study aimed to assess scientific activity regarding UC-MSC research. [Stem Cell Res Ther] Full Article Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSGlycoMimetics, Inc. announced that it has entered into an agreement with the Haemato Oncology Foundation for Adults in the Netherlands (HOVON) group to initiate clinical trial startup activities. In the planned clinical trial, HOVON researchers will evaluate GlycoMimetics’ drug candidate, GMI-1271, in adults with newly diagnosed AML but who cannot tolerate intensive chemotherapy, as well as in patients with myelodysplastic syndrome with a high risk of leukemia. [GlycoMimetics, Inc.] Press Release Celgene Spinoff Debuts with Big Names, Big Bucks and Big Hopes A Celgene spinout known as Celularity with some of the biggest names in biotech and Silicon Valley has raised an eye-watering $250 million for its work in cancer. The biotech’s research aim is to develop cells from placentas against blood cancers and is founded on the use of cord blood taken from placentas after childbirth. [FierceBiotech] Press Release | |
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POLICY NEWSTrump’s Science Advisor, Age 31, Has a Political Science Degree A job that’s been held by some of the nation’s top scientists is now occupied by a 31-year-old politics major from Princeton University. And it’s unlikely to change soon, observers say, leaving President Trump without a science adviser as the administration wrestles with a severe outbreak of the flu, lead-poisoned drinking water and record-breaking disasters that many scientists say are sharpened by rising temperatures. [Scientific American] Editorial Researchers Debate Whether Journals Should Publish Signed Peer Reviews Scientific journals should start routinely publishing the text of peer reviews for each paper they accept, said attendees at a meeting last week of scientists, academic publishers, and funding organizations. But there was little consensus on whether reviewers should have to publicly sign their critiques, which traditionally are accessible only to editors and authors. [ScienceInsider] Editorial NIH Stays Flat, Absorbs Three Institutes in President’s 2019 Budget Proposal Biomedical research funding was one of the budget lines saved from cuts by last-minute adjustments to President Donald Trump’s administration’s 2019 budget proposal. Still, advocates say they had hoped for more. [ScienceInsider] Editorial
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EVENTSNEW 6th Cambridge International Stem Cell Symposium Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Fellowship – Leukemia (Lund University) Postdoctoral Research Associate – Hematopoiesis (University of North Dakota) Postdoctoral Scholar – Leukemia (University of Southern California) Postdoctoral Research Fellow – Fanconi Anemia (Cincinnati Children’s Hospital Medical Center) Scientific Manager – Cell Engineering Lab (Genentech, Inc.) Research Fellow – Pediatric Cancer and Zebrafish Models (Massachusetts General Hospital) Postdoctoral Scientists and Research Technologists – Hematopoiesis and Leukemogenesis (City of Hope) Postdoctoral Fellow – Hematopoietic Stem Cell Biology (University of Colorado, Anschutz) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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