Cord Blood News 10.09 March 8, 2018 | |
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TOP STORYIsolated human bone marrow (BM) or umbilical cord (UC) MSCs adhered efficiently from flow to the matrix proteins, collagen or fibronectin, but did not adhere to endothelial selectins. However, when suspended in blood, BMMSC no longer adhered to collagen, while UCMSC adhered along with many aggregated platelets. [Stem Cells] Abstract | Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Transplanting expanded CD34+ stem cells from a portion of a single umbilical cord blood unit, with the remaining un-manipulated fraction improved 100 day survival compared to double-unit cord blood transplant controls while facilitating myeloid and platelet engraftment. [Biol Blood Marrow Transplant] Abstract The longitudinally-oriented collagen conduit and human umbilical cord MSCs synergistically promoted regeneration and improved the functional recovery in a dog model of sciatic nerve injury. [J Tissue Eng Regen Med] Abstract Wharton’s Jelly Derived Mesenchymal Stem Cells: Comparing Human and Horse Researchers showed that human and equine Wharton’s jelly MSCs have similar ultrastructural details connected with intense synthetic and metabolic activity, but differ in growth, migration, adhesion capability and differentiation potential. [Stem Cell Rev] Abstract Investigators examined the effects of FOXQ1 on senescence and migration of MSCs. Lentiviral vector-mediated overexpression of FOXQ1 in human umbilical cord MSCs resulted in enhanced cell proliferation and viability. The expression of proteins and markers positively associated with senescence was reduced, whereas expression of proteins negatively associated with senescence was promoted. [Cell Tissue Res] Abstract Scientists investigated the potential therapeutic benefits of intravitreally transplanted human umbilical cord MSCs in an animal model of microbead-injection-induced ocular hypertension. [Curr Eye Res] Abstract Biological Characterization and Pluripotent Identification of Ovine Amniotic Fluid Stem Cells The authors obtained amniotic fluid stem cells (AFSCs) from ovine amniotic fluid and studied the expansion capacity, cell markers expression, karyotype, and multilineage differentiation ability. AFSCs were successfully induced to differentiate into adipocytes, osteoblasts and chondrocytes. [Cytotechnology] Abstract Investigators explored the metabolic behavior of Wharton’s Jelly MSCs in in vitro culture to identify biomarkers that are specific to the cell passage effect and the loss of their immunosuppressive phenotype. [Metabolites] Full Article MSCs treated with culture media containing fetal bovine serum and peripheral blood-platelet lysates (PL) were successfully isolated and expanded, whereas MSCs treated with cord blood-PL could not be maintained in culture. [Bioengineering] Full Article | |
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REVIEWSMesenchymal Stem Cells in Multiple Myeloma: A Therapeutical Tool or Target? Researchers focus on the current understanding of the biological role of MSCs in multiple myeloma as well as the potential utility of MSC-based therapies in this malignancy. [Leukemia] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSTrovagene, Inc. announced that the initial patient successfully completed the first cycle 1 of treatment in its Phase Ib/II multicenter trial of PCM-075 in combination with LDAC in patients with acute myeloid leukemia (AML). [Trovagene, Inc.] Press Release Shire plc announced that the FDA has accepted the Biologics License Application for Calaspargase Pegol. The investigational-stage compound is being reviewed as a component of a multi-agent chemotherapeutic regimen for the treatment of patients with ALL. [Shire plc] Press Release | |
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POLICY NEWSRise of Nationalist and Populist Parties Has Italian Scientists Worried The outcome of parliamentary elections in Italy was a stunning victory for populist and nationalist parties, and a clear warning to Italy’s political establishment and the European Union. But some in Italy worry that the results may also have a negative impact on science. [ScienceInsider] Editorial What Researchers Can Expect from China’s Top-Level Political Meetings As Chinese leaders gather for the government’s most significant meetings of the year, researchers are anticipating major policy announcements for science and innovation that could shape the country’s research agenda for years. [Nature News] Editorial New NSF Rules on Sexual Harassment Leave Many Questions Unanswered The National Science Foundation (NSF) in Alexandria, Virginia, hopes that its new policy on sexual harassment will spur universities to deal more aggressively with the pervasive problem. But the additional reporting requirements, which will be officially published in the Federal Register, are far from a definitive statement about how NSF plans to deal with this complex and sensitive subject. [ScienceInsider] Editorial
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EVENTSNEW Cell Symposia: Translation of Stem Cells to the Clinic: Challenges and Opportunities Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowship – Cell and Molecular Biology (Canadian Nuclear Laboratories) Postdoctoral Positions – Molecular Biology (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellow & Scientist – Acute Myeloid Leukemia (Institute of Hematology) Postdoctoral Fellowship – Functional Genomics of Human Hematopoiesis (Boston Children’s Hospital) Postdoctoral Fellowship – Leukemia (Lund University) Postdoctoral Research Associate – Hematopoiesis (University of North Dakota) Postdoctoral Scholar – Leukemia (University of Southern California) Postdoctoral Research Fellow – Fanconi Anemia (Cincinnati Children’s Hospital Medical Center) Scientific Manager – Cell Engineering Lab (Genentech, Inc.) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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