Cord Blood News Volume 10.11 | Mar 22 2018

TOP STORY

Molecular Transitions in Early Progenitors during Human Cord Blood Hematopoiesis

The authors leveraged Drop‐seq, a massively parallel single‐cell RNA sequencing approach, to individually profile 20,000 progenitor cells from human cord blood, without prior enrichment or depletion for individual lineages based on surface markers. [Mol Syst Biol] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Comparison of the Biological Characteristics of Mesenchymal Stem Cells Derived from the Human Placenta and Umbilical Cord

Investigators compared MSCs derived from different perinatal tissues, including the umbilical cord, amniotic membrane, chorionic plate and decidua parietalis. Using human leukocyte antigen typing and karyotype analysis, they found that the first three cell types were derived from the fetus, while the MSCs from the decidua parietalis were derived from the maternal portion of the placental tissue. [Sci Rep] Full Article

Elevated Soluble Human Leukocyte Antigen G Levels in Patients after Allogeneic Stem Cell Transplantation Are Associated with Less Severe Acute and Chronic Graft-versus-Host Disease

The authors present detailed analyses of human leukocyte antigen (HLA)-G-levels in patients after allogeneic stem cell transplantation showing a correlation of elevated soluble HLA-G levels with less severe acute and chronic graft-versus-host disease and with a superior overall survival. [Bone Marrow Transplant] Abstract

Functional Organic Cation Transporters Mediate Osteogenic Response to Metformin in Human Umbilical Cord Mesenchymal Stromal Cells

Scientists demonstrated that functional organic cation transporters are expressed in human-derived MSCs from umbilical cord Wharton’s jelly, an inexhaustible source of nonembryonic MSCs with proven osteogenic potential. [Cytotherapy] Abstract

Transplantation of UC-MSCs on Collagen Scaffold Activates Follicles in Dormant Ovaries of POF Patients with Long History of Infertility

Transplantation of collagen/umbilical cord (UC)-MSCs to the ovaries of premature ovarian failure (POF) patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. [Sci China Life Sci] Abstract

Isolation and Characterization of Buffalo (Bubalus bubalis) Amniotic Mesenchymal Stem Cells Derived from Amnion from the First Trimester Pregnancy

Researchers explored a suitable way to isolate and culture the buffalo amniotic mesenchymal stem cells, and to identify their biological characteristics. [J Vet Med Sci] Abstract

Transplantation and Alternatives to Treat Autoimmune Diseases

Cord blood transplantation is favored over other transplant techniques. The propelled treatments incorporate interferon administrative elements and mesenchymal stromal cells for the management of immune system issue particularly in the treatment of rheumatoid joint inflammation. [Adv Exp Med Biol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Gamida Cell to Present Immune Reconstitution Data for its NiCord^® Program

Gamida Cell announced that new data on immune reconstitution from its Phase I/II study of NiCord in high-risk hematologic malignancies will be presented. [Press release from Gamida Cell discussing research to be presented at the 44^th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), Lisbon] Press Release

FDA Expands Approval of Adcetris for First-Line Treatment of Stage III or IV Classical Hodgkin Lymphoma in Combination with Chemotherapy

FDA approved Adcetris to treat adult patients with previously untreated stage III or IV classical Hodgkin lymphoma in combination with chemotherapy. [The U.S. Food and Drug Administration] Press Release

Novartis Drug Tasigna^® Approved by FDA to Treat Children with Rare Form of Leukemia

Novartis announced that the FDA expanded the indication for Tasigna^® to include treatment of first- and second-line pediatric patients one year of age or older with Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase. [Novartis] Press Release

AbbVie and the International Myeloma Foundation Announce Partnership to Study the Role of a Genetic Mutation in Outcomes of Patients with Multiple Myeloma

AbbVie and the International Myeloma Foundation announced they have entered into a collaboration to conduct a landmark retrospective chart review study to better understand and help manage multiple myeloma, the second most common blood cancer. [AbbVie Inc.] Press Release

US Science Agencies Set to Win Big in Budget Deal

Nearly all US science agencies would see their budgets grow in 2018, under a US$1.3-trillion spending deal announced. For the second year in a row, lawmakers in Congress seem set to ignore the steep cuts sought by President Donald Trump. [Nature News] Editorial

Expectations Are High for UKRI, the United Kingdom’s New £6 Billion Research Behemoth

Combine U.S. agencies akin to the National Institutes of Health, National Science Foundation, and National Endowment for the Humanities. Toss in some energy and innovation research and fuel it all with the largest boost in R&D spending in recent history. Then put one person in charge. [ScienceInsider] Editorial

HIV Researcher Is New Head of US Public-Health Agency

HIV researcher Robert Redfield will lead the Centers for Disease Control and Prevention, Secretary of Health and Human Services Alex Azar announced. [Nature News] Editorial

NEW Arizona Cord Blood Conference 2018 – Advancing Innovation
April 13, 2018
Tempe, Arizona, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Scholar – Hematology (Huntsman Cancer Institute)

NEW Postdoctoral Scholar – Clonal Hematopoiesis (Stanford University)

Postdoctoral Fellow – Leukemia (Washington University)

Postdoctoral Fellowship – Cell and Molecular Biology (Canadian Nuclear Laboratories)

Postdoctoral Positions – Molecular Biology (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow & Scientist – Acute Myeloid Leukemia (Institute of Hematology)

Postdoctoral Fellowship – Functional Genomics of Human Hematopoiesis (Boston Children’s Hospital)

Postdoctoral Fellow Positions – Hematopoietic Stem Cell Biology (Nationwide Childrens Hospital and Ohio State University)

Postdoctoral Research Fellow – Fanconi Anemia (Cincinnati Children’s Hospital Medical Center)

Scientific Manager – Cell Engineering Lab (Genentech, Inc.)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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