Cord Blood News Volume 10.14 | Apr 12 2018

TOP STORY

PLAG1 and USF2 Co-Regulate Expression of Musashi-2 in Human Hematopoietic Stem and Progenitor Cells

Overexpression of USF2 and PLAG1 in primitive cord blood cells enhanced musashi-2 MSI2 transcription and yielded cellular phenotypes, including expansion of CD34⁺ cells in vitro, consistent with that achieved by direct MSI2 overexpression [Stem Cell Reports] Full Article

(Ranked by impact factor of the journal)

Ocular Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation in an Italian Referral Center

Scientists assessed the prevalence and clinical manifestations of ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. [Ocul Surf] Abstract

Ceramic Hollow Fibre Constructs for Continuous Perfusion and Cell Harvest from 3D Hematopoietic Organoids

Investigators describe the fabrication and testing of ceramic hollow fibre membranes (HFs) able to separate red blood cells (RBCs) and mononuclear cells and be incorporated into 3D tissue models to improve nutrient and metabolite exchange. These HFs filtered RBCs from human umbilical cord blood suspensions of 20% RBCs to produce 90% RBC filtrate suspensions. [Stem Cells Int] Abstract

The Iron Regulatory Proteins Are Defective in Repressing Translation via Exogenous 5′ Iron Responsive Elements despite Their Relative Abundance in Leukemic Cellular Models

The distribution of the mRNA belonging to the cellular iron network was similar in human leukemic cell lines and in normal cord blood progenitors, with differences among the cellular models only associated with their different propensities to synthesize hemoglobin. [Metallomics] Abstract

Expression Profile of Long Non-Coding RNAs during the Differentiation of Human Umbilical Cord Derived Mesenchymal Stem Cells into Cardiomyocyte-Like Cells

The authors investigated the differentially expressed long non-coding RNAs during the differentiation of human umbilical cord derived MSCs into cardiomyocyte-like cells induced by 5-aza. [Cytotechnology] Abstract

Isolation of Human Mesenchymal Stem Cells from Amnion, Chorion, Placental Decidua and Umbilical Cord: Comparison of Four Enzymatic Protocols

Researchers compared four enzymatic protocols for MSCs isolation from amniotic and chorionic membranes, umbilical cord and placental decidua in order to define a robust, practical and low-cost protocol for each tissue. [Biotechnol Lett] Abstract

The Changing Face of Hematopoiesis: A Spectrum of Options Is Available to Stem Cells

Recent findings of lineage biases or affiliations within hematopoietic stem and progenitor cells that are either pluripotent or uni‐potent show that a continuum of fate options is open to hematopoietic stem cells. These results support the view that in order to close down developmental options, hematopoietic stem cells can make an immediate lineage choice rather than become gradually committed as they progress step‐wise through a series of intermediate progenitors. [Immunol Cell Biol] Abstract

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Cancer Researchers Receive More Than $2 Million to Eradicate Common Form of Leukemia

Christoph Rader, PhD, associate professor at the Florida campus of The Scripps Research Institute, has been awarded a $2.875 million, five-year grant from the National Cancer Institute to develop unique antibody-drug conjugates engineered to eradicate one of the most common forms of leukemia, chronic lymphocytic leukemia. [The Scripps Research Institute] Press Release

Kadmon Receives FDA Guidance on Pivotal Clinical Trial Design for KD025 in Chronic Graft-versus-Host Disease

Kadmon Holdings, Inc. announced that it has received final minutes from a Type C meeting with the FDA regarding the development pathway for KD025, the company’s Rho-associated coiled-coil kinase 2 inhibitor, for the treatment of chronic graft-versus-host disease. [Kadmon Holdings, Inc.] Press Release

The March for Science Is Back — and Here’s What to Expect

Nature takes a look at why people are marching, how the movement has changed over time and what its future could bring. [Nature News] Editorial

Spanish Research Gets a Nice Budget Boost—but Scientists Say It Will Be of Little Help

The Spanish government has announced plans to raise the country’s overall public R&D budget by 8.3% in 2018, from €6.5 billion to €7 billion—the biggest hike since the economic crisis hit Spain in 2008. [ScienceInsider] Editorial

Web of Science Owner Buys Tool that Offers One-Click Access to Journal Articles

The owner of the large scholarly search engine Web of Science — Clarivate Analytics — has bought a start-up company whose tool gives researchers one-click, legal access to journal articles even when off campus. [Nature News] Editorial

India Creates Unique Tiered System to Punish Plagiarism

The Indian government has adopted its first regulations on academic plagiarism—rules that some researchers say are too lenient and others fear go too far and will be difficult to implement. [ScienceInsider] Editorial

NEW American Society of Hematology (ASH) Meeting on Lymphoma Biology
August 2-5, 2018
Chicago, Illinois, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Molecular and Translational Cancer Biology (Thomas Jefferson University)

Postdoctoral Position – Hematology (Yale Cancer Center)

Research Technician – Acute Myeloid Leukemia (European Molecular Biology Laboratory)

Bioinformatics Research Scientist – Brain Tumors and Leukemia (St. Jude Children’s Research Hospital)

Pathology Faculty Tenure Track – Leukemia and Hematopoiesis (University of Virginia)

Postdoctoral Scholar – Hematology (Huntsman Cancer Institute)

Postdoctoral Scholar – Clonal Hematopoiesis (Stanford University)

Postdoctoral Fellow – Leukemia (Washington University)

Postdoctoral Fellowship – Cell and Molecular Biology (Canadian Nuclear Laboratories)

Postdoctoral Positions – Molecular Biology (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow & Scientist – Acute Myeloid Leukemia (Institute of Hematology)

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