Cord Blood News Volume 10.15 | Apr 19 2018

TOP STORY

HIV-Specific T-cells Generated from Naive T-cells can Suppress HIV In Vitro, Display Cytotoxicity, and Recognize Wide Epitope Breadths

Researchers showed that multi-antigen HIV-specific T-cells can be generated from naïve T-cells of both cord blood and adults using a reproducible good-manufacturing practice grade protocol. This product lysed antigen-pulsed targets and suppressed active HIV in vitro. [Mol Ther] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Interleukin-1 Receptor Antagonist-Mediated Neuroprotection by Umbilical Cord-Derived Mesenchymal Stromal Cells following Transplantation into a Rodent Stroke Model

Scientists investigated the therapeutic effects and mechanisms of their good manufacturing practice-manufactured human umbilical cord-derived MSCs (hUMSCs) using various cell doses and delivery time points in a rodent model of stroke. Intravenous-hUMSCs at a dose of 1 × 106 cells at 24 hours after stroke improved functional deficits and reduced neuronal damage by attenuation of post-ischemic inflammation. [Exp Mol Med] Full Article

Human Umbilical Cord Mesenchymal Stem Cells Facilitate the Up‐Regulation of miR‐153‐3p, Whereby Attenuating MGO‐Induced Peritoneal Fibrosis in Rats

The authors tried to profile whether miRNA expression differences exist after human umbilical cord MSCs treatment in peritoneal fibrosis rats and investigated the possible role of miR‐153‐3p involved in anti‐epithelial to mesenchymal transition process. [J Cell Mol Med] Full Article

The Double-Edged Effect of Hydroxychloroquine on Human Umbilical Cord-Derived Mesenchymal Stem Cells Treating Lupus Nephritis in MRL/Lpr Mice

Hydroxychlorquine (HCQ) and umbilical cord-derived MSCs (UC-MSCs) were used in MRL/lpr mice. Although the treatment of both HCQ and UC-MSCs could ameliorate renal damage separately, the presence of HCQ decreased unexpectedly the therapeutic effects of UC-MSCs through interfering expression of IFN-γ. [Mol Pharm] Abstract

Attenuated DNA Damage Responses and Increased Apoptosis Characterize Human Hematopoietic Stem Cells Exposed to Irradiation

Researchers found that irradiated hematopoietic stem and early progenitor cells, but not lineage-committed progenitors, undergo rapid ATM-dependent apoptosis, which is suppressed upon interaction with bone-marrow stroma cells. [Sci Rep] Full Article

The Iron Regulatory Proteins Are Defective in Repressing Translation via Exogenous 5′ Iron Responsive Elements despite Their Relative Abundance in Leukemic Cellular Models

The distribution of the mRNA belonging to the cellular iron network is similar in human leukemic cell lines and in normal cord blood progenitors, with differences among the cellular models only associated with their different propensities to synthesize hemoglobin. Thus, the iron regulatory protein regulator was in large excess over its presently identified regulated mRNA targets. [Metallomics] Abstract | Graphical Abstract

Conditioned Medium from Umbilical Cord Mesenchymal Stem Cells Improves Nasal Mucosa Damage by Radiation

The proliferation and migration abilities of irradiated and non-irradiated nasal epithelial cells significantly increased after culture in bronchial epithelial cell growth medium (BEGM) containing 10% conditioned medium of human umbilical cord-MSCs compared to cells cultured in BEGM alone. [Biotechnol Lett] Abstract

Autophagy as a Pharmacological Target in Hematopoiesis and Hematological Disorders

Scientists present therapeutic strategies and pharmacological agents in the context of hematological disorders. [Biochem Pharmacol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

StemCyte, Inc. Announces the Expansion of Two New Umbilical Cord Blood Collection Sites in Southern California

StemCyte, Inc. announced the expansion of two new umbilical cord blood collection sites in Southern California. [StemCyte, Inc. (PR Newswire Association LLC.)] Press Release

Could Stem Cells Repair the Heart, Fight Infections, Mend Premature Lungs, and Heal the Brain after Stroke?

Researchers from The Ottawa Hospital, CHEO and the University of Ottawa are bringing discoveries made in the lab closer to human trials and therapies, thanks to five new peer-reviewed research grants from the Stem Cell Network worth $999,900, part of an overall investment of $4 million across Canada. [The Ottawa Hospital] Press Release

Dutch Universities, Journal Publishers Agree on Open-Access Deals

Despite some difficult negotiations, academic institutions in the Netherlands have been securing subscriptions that combine publishing and reading into one fee. [The Scientist] Editorial

African Scientists Call for More Control of Their Continent’s Genomic Data

Africa-based researchers issued guidelines for the ethical handling of samples for genomic studies. The voluntary rules are an effort to combat ‘helicopter’ research, in which foreign scientists take samples and data from communities and then return to their home institutions. [Nature News] Editorial

A Final Dash across the United States: Updates from the 2018 March for Science

The March for Science celebrated its anniversary. And although the turnout around the world was significantly smaller than last year, supporters haven’t lost any of their energy. [ScienceInsider] Editorial

Spain’s Biggest-Ever Science Petition Decries ‘Abandonment’ of Research

Leading Spanish scientific organizations delivered a petition signed by more than 277,000 people to the national parliament in Madrid, calling on the government to stop the “progressive abandonment of science in Spain” caused by budget cuts. The petition is the largest ever on a science-policy subject in Spain. [Nature News] Editorial

NEW 5^th International Placenta Stem Cell Society (IPLASS) Meeting
September 6-7, 2018
Bern, Switzerland

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Chronic Lymphocytic Leukemia (Università della Svizzera italiana)

Postdoctoral Fellow – Molecular and Translational Cancer Biology (Thomas Jefferson University)

Postdoctoral Position – Hematology (Yale Cancer Center)

Research Technician – Acute Myeloid Leukemia (European Molecular Biology Laboratory)

Bioinformatics Research Scientist – Brain Tumors and Leukemia (St. Jude Children’s Research Hospital)

Pathology Faculty Tenure Track – Leukemia and Hematopoiesis (University of Virginia)

Postdoctoral Scholar – Hematology (Huntsman Cancer Institute)

Postdoctoral Scholar – Clonal Hematopoiesis (Stanford University)

Postdoctoral Fellow – Leukemia (Washington University)

Postdoctoral Fellowship – Cell and Molecular Biology (Canadian Nuclear Laboratories)

Postdoctoral Positions – Molecular Biology (Memorial Sloan Kettering Cancer Center)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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