Cord Blood News 10.15 April 20, 2018 | |
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TOP STORYResearchers showed that multi-antigen HIV-specific T-cells can be generated from naïve T-cells of both cord blood and adults using a reproducible good-manufacturing practice grade protocol. This product lysed antigen-pulsed targets and suppressed active HIV in vitro. [Mol Ther] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists investigated the therapeutic effects and mechanisms of their good manufacturing practice-manufactured human umbilical cord-derived MSCs (hUMSCs) using various cell doses and delivery time points in a rodent model of stroke. Intravenous-hUMSCs at a dose of 1 × 106 cells at 24 hours after stroke improved functional deficits and reduced neuronal damage by attenuation of post-ischemic inflammation. [Exp Mol Med] Full Article The authors tried to profile whether miRNA expression differences exist after human umbilical cord MSCs treatment in peritoneal fibrosis rats and investigated the possible role of miR‐153‐3p involved in anti‐epithelial to mesenchymal transition process. [J Cell Mol Med] Full Article Hydroxychlorquine (HCQ) and umbilical cord-derived MSCs (UC-MSCs) were used in MRL/lpr mice. Although the treatment of both HCQ and UC-MSCs could ameliorate renal damage separately, the presence of HCQ decreased unexpectedly the therapeutic effects of UC-MSCs through interfering expression of IFN-γ. [Mol Pharm] Abstract Researchers found that irradiated hematopoietic stem and early progenitor cells, but not lineage-committed progenitors, undergo rapid ATM-dependent apoptosis, which is suppressed upon interaction with bone-marrow stroma cells. [Sci Rep] Full Article The distribution of the mRNA belonging to the cellular iron network is similar in human leukemic cell lines and in normal cord blood progenitors, with differences among the cellular models only associated with their different propensities to synthesize hemoglobin. Thus, the iron regulatory protein regulator was in large excess over its presently identified regulated mRNA targets. [Metallomics] Abstract | Graphical Abstract The proliferation and migration abilities of irradiated and non-irradiated nasal epithelial cells significantly increased after culture in bronchial epithelial cell growth medium (BEGM) containing 10% conditioned medium of human umbilical cord-MSCs compared to cells cultured in BEGM alone. [Biotechnol Lett] Abstract | |
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REVIEWSAutophagy as a Pharmacological Target in Hematopoiesis and Hematological Disorders Scientists present therapeutic strategies and pharmacological agents in the context of hematological disorders. [Biochem Pharmacol] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSStemCyte, Inc. announced the expansion of two new umbilical cord blood collection sites in Southern California. [StemCyte, Inc. (PR Newswire Association LLC.)] Press Release Researchers from The Ottawa Hospital, CHEO and the University of Ottawa are bringing discoveries made in the lab closer to human trials and therapies, thanks to five new peer-reviewed research grants from the Stem Cell Network worth $999,900, part of an overall investment of $4 million across Canada. [The Ottawa Hospital] Press Release | |
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POLICY NEWSDutch Universities, Journal Publishers Agree on Open-Access Deals Despite some difficult negotiations, academic institutions in the Netherlands have been securing subscriptions that combine publishing and reading into one fee. [The Scientist] Editorial African Scientists Call for More Control of Their Continent’s Genomic Data Africa-based researchers issued guidelines for the ethical handling of samples for genomic studies. The voluntary rules are an effort to combat ‘helicopter’ research, in which foreign scientists take samples and data from communities and then return to their home institutions. [Nature News] Editorial A Final Dash across the United States: Updates from the 2018 March for Science The March for Science celebrated its anniversary. And although the turnout around the world was significantly smaller than last year, supporters haven’t lost any of their energy. [ScienceInsider] Editorial Spain’s Biggest-Ever Science Petition Decries ‘Abandonment’ of Research Leading Spanish scientific organizations delivered a petition signed by more than 277,000 people to the national parliament in Madrid, calling on the government to stop the “progressive abandonment of science in Spain” caused by budget cuts. The petition is the largest ever on a science-policy subject in Spain. [Nature News] Editorial
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EVENTSNEW 5th International Placenta Stem Cell Society (IPLASS) Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Chronic Lymphocytic Leukemia (Università della Svizzera italiana) Postdoctoral Fellow – Molecular and Translational Cancer Biology (Thomas Jefferson University) Postdoctoral Position – Hematology (Yale Cancer Center) Research Technician – Acute Myeloid Leukemia (European Molecular Biology Laboratory) Pathology Faculty Tenure Track – Leukemia and Hematopoiesis (University of Virginia) Postdoctoral Scholar – Hematology (Huntsman Cancer Institute) Postdoctoral Scholar – Clonal Hematopoiesis (Stanford University) Postdoctoral Fellow – Leukemia (Washington University) Postdoctoral Fellowship – Cell and Molecular Biology (Canadian Nuclear Laboratories) Postdoctoral Positions – Molecular Biology (Memorial Sloan Kettering Cancer Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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