Cord Blood News 10.24 June 21, 2018 | |
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TOP STORYThe authors developed a poly(lactic-co-glycolic acid) (PLGA) nanoparticle with a layer of plasma membrane from umbilical cord MSC coating on the surface for tumor-targeted delivery of chemotherapy. Functionalization of MSC plasma membrane significantly enhanced the cellular uptake efficiency of PLGA nanoparticles, the tumor cell killing efficacy of PLGA-encapsulated doxorubicin, and most importantly the tumor-targeting and accumulation of the nanoparticles. [ACS Appl Mater Interfaces] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)SERPINB2 Is a Novel Indicator of Stem Cell Toxicity Researchers identified a labile toxic response gene, SERPINB2, which is significantly increased in response to various toxic agents in human stem cells in vitro and in vivo. [Cell Death Dis] Full Article Human MSCs derived from many adult (bone marrow and adipose tissue) or fetal (cord blood, Wharton’s jelly, umbilical cord perivascular compartment and amniotic fluid) tissues were investigated. Their immunophenotype was analyzed to define consistent source-specific markers by extensive flow cytometry analysis and real-time qRT-PCR. [Sci Rep] Full Article Scientists performed a coculture of cord blood CD34+ cells with Wharton’s jelly MSCs under different O2 concentration to simulate the growth of hematopoietic stem/progenitor cells (HSPCs) in vivo, and assessed the impacts on stemness maintenance and proliferation of cord blood HSPCs in vitro. [Stem Cell Res Ther] Full Article Researchers successfully expanded natural killer (NK) cells from umbilical cord blood (UCB) with membrane-bound IL-21, termed eUCB-NK cells. eUCB-NK cells efficiently lysed colorectal cancer cell lines in vitro and secreted significantly higher levels of IFN-γ, TNF-α, GM-CSF and CCL3 compared with IL-2 stimulated NK cells. [Hum Gene Ther] Abstract Investigators compared amniotic fluid (AF) MSCs and bone marrow (BM) MSCs in terms of cell proliferation, surface markers, multidifferentiation potential, senescence, and DNA repair capacity. They showed that AF‐MSCs were less prone to senescence with respect to BM‐MSCs. [J Cell Physiol] Abstract Umbilical cord (UC)-MSCs were induced to differentiate into hepatocytes and were compared with bone marrow (BM)-MSCs for their hepatic differentiation potential. UC-MSCs showed significantly higher proliferation than BM-MSCs. [Mol Med Rep] Abstract | |
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REVIEWSTranslational Regenerative Therapies for Chronic Spinal Cord Injury The advancements of nanoscience and stem cell technology, combined with the powerful, novel neuroimaging modalities that have arisen can now accelerate the path of promising novel therapeutic strategies from bench to bedside. Several types of stem cells have reached up to clinical trials phase II, including adult neural stem cells, human spinal cord stem cells, olfactory ensheathing cells, autologous Schwann cells, umbilical cord blood-derived mononuclear cells, adult mesenchymal cells, and autologous bone-marrow-derived stem cells. [Int J Mol Sci] Full Article | Graphical Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSTrovagene, Inc. announced completion of the first dose cohort of PCM-075, a highly-selective polo-like kinase 1 inhibitor, in combination with decitabine, in its Phase Ib/II clinical trial in patients with acute myeloid leukemia (AML). [Trovagene, Inc.] Press Release Celyad announced the successful injection of the first acute myeloid leukemia (AML) patient at the third and final dose level of CYAD-01 in the hematological arm of the Phase I THINK trial. [Celyad] Press Release | |
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POLICY NEWSHundreds of U.S. Scientists Urge More Transparency in Animal Research Breaking with a history of reticence, nearly 600 scientists, students, and lab animal workers published a letter in USA Today that calls on U.S. research institutions to “embrace openness” about their animal research. [ScienceInsider] Editorial U.S. Legislators Back Larger Facilities Budget for NSF The National Science Foundation (NSF) in Alexandria, Virginia, is in line for a budget increase of 4% to 5% next year. That assessment is based on bills approved recently by the spending committees in both chambers of Congress. Lawmakers have also signaled support for growing the account that NSF uses to build major new scientific facilities. [ScienceInsider] Editorial Why the Medical Research Grant System Could Be Costing Us Great Ideas The medical research grant system in the United States, run through the National Institutes of Health, is intended to fund work that spurs innovation and fosters research careers. In many ways, it may be failing. [The New York Times] Editorial
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EVENTSNEW World Cord Blood Day 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow Positions – Hematopoietic Stem Cell Biology (Nationwide Children’s Hospital) Research Fellow – Epigenetics and Hematology (University of Edinburgh) PhD Student – Cellular Immunotherapy (Glycostem Therapeutics) Research Associate – Advanced Cell Culture Biology (The University of Manchester) Postdoctoral Fellowship – Myeloid Tumors (St. Jude Children’s Research Hospital) Postdoctoral Positions – Cell Biology (Children’s Hospital of Philadelphia) Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine) Postdoctoral Fellow – Hematopoiesis and Leukemia (University of Pennsylvania) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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