Cord Blood News Volume 10.26 | Jul 5 2018

TOP STORY

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia

Researchers demonstrated that CBFβ-SMMHC maintained cell viability by neutralizing RUNX1-mediated repression of MYC expression. Combining the CBFβ-SMMHC inhibitor with the BET inhibitor JQ1 eliminated inv(16) leukemia in human cells and a mouse model. [Cell] Full Article | Graphical Abstract

(Ranked by impact factor of the journal)

UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells

Using a 22-hour transduction protocol, scientists found that UM171 significantly enhanced both the lentivirus-mediated transduction and yield of CD34⁺ and CD34⁺CD45RA^– hematopoietic cells from human cord blood to give a 6-fold overall higher recovery of transduced hematopoietic stem cells, including cells with long-term lympho-myeloid repopulating activity in immunodeficient mice. [Mol Ther Methods Clin Dev] Full Article

Human Mesenchymal Stem Cell-Derived Extracellular Vesicles/Estrogen Combined Therapy Safely Ameliorates Experimentally Induced Intrauterine Adhesions in a Female Rat Model

Researchers investigated the systemic administration of extracellular vesicles derived from human umbilical cord MSCs as a therapeutic agent for intrauterine adhesions caused by endometrial injury. [Stem Cell Res Ther] Full Article

Efficient Generation of Functional Cardiomyocytes from Human Umbilical Cord-Derived Virus-Free Induced Pluripotent Stem Cells

The authors generated induced pluripotent stem cells (iPSCs) from umbilical cord-derived MSCs using mRNA reprogramming and focused on the differentiation of reprogrammed iPSCs into functional cardiomyocytes. [Cell Tissue Res] Abstract

Preparation, Culture, and Analysis of Amniotic Fluid Samples

Researchers described an in situ method for the preparation, culture, and harvest of amniotic fluid samples for metaphase chromosome analysis. [Curr Protoc Hum Genet] Abstract

ROCK Y-27632 Inhibitor, Ascorbic Acid, and Trehalose Increase Survival of Human Wharton Jelly Mesenchymal Stem Cells after Cryopreservation

Investigators observed significantly increased post thaw viability, increased cell proliferation, and decreased doubling time of cells when 75 mM trehalose, 0.25 and 0.5 mM ascorbic acid, and 10 mM Y-27632 were used. [Exp Clin Transplant] Full Article

Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News.

The Current Understanding of Mesenchymal Stem Cells as Potential Attenuators of Chemotherapy‐Induced Toxicity

The authors present a concise review of the published data regarding the influence of various classes of chemotherapeutic agents on the survival, stem cell characteristics and physiological functions of MSCs. Molecular mechanisms underlying the effects are outlined, and resulting challenges of MSC‐based treatments for chemotherapy‐induced tissue injuries are discussed. [Int J Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

£215 Million Research Fund to Tackle the Next Generation of Health Challenges

The government has announced £215 million investment in NHS health research and an additional £3 million for a new research leader program for nurses and midwives. [Gov.UK] Press Release

European Commission Approves Expanded Indication for Sprycel (Dasatinib) to Include Treatment of Children with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase

Bristol-Myers Squibb Company announced that the European Commission has expanded the indication for Sprycel to include the treatment of children and adolescents aged 1 year to 18 years with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase, and to include a powder for oral suspension formulation. [Bristol-Myers Squibb Company] Press Release

Vyxeos^™ Receives Positive CHMP Opinion for Treatment of Certain Types of High-Risk Acute Myeloid Leukemia

Jazz Pharmaceuticals plc announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion recommending marketing authorization of Vyxeos^™ 44 mg/100 mg powder for concentrate for solution for infusion for the treatment of adults with newly diagnosed, therapy-related acute myeloid leukemia or acute myeloid leukemia with myelodysplasia-related changes. [Jazz Pharmaceuticals plc] Press Release

Hidden Conflicts? Pharma Payments to FDA Advisers after Drug Approvals Spark Ethical Concerns

In examining compensation records from drug companies to physicians who advised FDA on whether to approve 28 psychopharmacologic, arthritis, and cardiac or renal drugs between 2008 and 2014, Science found widespread after-the-fact payments or research support to panel members. The agency’s safeguards against potential conflicts of interest are not designed to prevent such future financial ties. [ScienceInsider] Editorial

A Better Measure of Research from the Global South

Funders Jean Lebel and Robert McLean describe a new tool for judging the value and validity of science that attempts to improve lives. [Nature News] Editorial

Hungarian Academy to Draw Up Alternative Research Budget

The Hungarian Academy of Sciences is set to put forward an “alternative proposal” for the country’s research budget, after the government moved to put the Ministry of Innovation and Technology in charge of financing research institutions, seen as the latest attack on sector autonomy by the authoritarian Orbán administration. [Times Higher Education] Editorial

NEW International Society for Stem Cell Research (ISSCR) 2019 Annual Meeting
June 26-29, 2019
Los Angeles, California, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Cancer Drug Discovery (University of Michigan)

NEW Postdoctoral Position – Hematology (Uppsala University)

Postdoctoral Associate – Cancer Biology (Trustees of Boston University Medical Campus)

Postdoctoral Fellow Positions – Hematopoietic Stem Cell Biology (Nationwide Children’s Hospital)

Research Fellow – Epigenetics and Hematology (University of Edinburgh)

PhD Student – Cellular Immunotherapy (Glycostem Therapeutics)

Postdoctoral Fellowship – Myeloid Tumors (St. Jude Children’s Research Hospital)

Postdoctoral Positions – Cell Biology (Children’s Hospital of Philadelphia)

Assistant, Associate, or Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – 3D Chromatin Architecture, Epigenetics and Metabolism (Josep Carreras Leukaemia Research Institute)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Cord Blood News? Click here to submit!

Comments or suggestions? Submit your feedback here.