Cord Blood News 10.27 July 12, 2018 | |
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TOP STORYScientists used a quantitative phospho-tyrosine analysis to generate a comprehensive signaling map of granulocyte-colony stimulating factor (G-CSF) induced tyrosine phosphorylation in the normal versus mutated G-CSF receptors (G-CSFRs). Primary murine progenitor cells from G-CSFR knock-in mice validated activation of Bruton’s tyrosine kinase by the mutant receptor and retrovirally transduced human CD34+ umbilical cord blood cells expressing mutant receptors displayed enhanced sensitivity to Ibrutinib. [Leukemia] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors induced a type 2 diabetes mouse model with a combination of high-fat diet and low-dose streptozotocin, and then performed human umbilical cord-derived MSCs infusion to investigate whether the effect of MSCs on islet protection was related to regulation of macrophages in pancreatic islets. [Cell Death Dis] Full Article Investigators performed a proteomic profiling of human mesenchymal stem cells derived from adipose tissue or umbilical cord and identified peptides derived from 13 of such missing proteins. They found compelling evidence of the expression of hyaluronan synthase 1 and confirmed its identification by the fragmentation of four heavy-labeled peptides that coeluted with their endogenous light counterparts. [J Proteome Res] Abstract | Graphical Abstract Studies focusing on plasmatic coagulation suggested both procoagulatory and anticoagulatory activities of MSCs. Researchers showed that MSCs can, dependent on their tissue origin, inhibit platelet activation involving adenosine converted from adenosine monophosphate by CD73 ectonucleotidase activity. [Stem Cell Res Ther] Full Article The authors investigated whether cell-based screening could detect hepatitis B virus (HBV) in human umbilical cord-derived mesenchymal stem cells (HUMSCs) isolated from HBV-infected donors to understand the susceptibility of HUMSCs to HBV infection. [Stem Cell Res Ther] Full Article Human umbilical cord-derived MSCs (UC-MSCs) were infused into lupus-prone B6.MRL-Faslpr mice to investigate the influences of UC-MSCs on podocyte injury in lupus nephritis. [Nephrol Dial Transplant] Abstract Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSManipulation of Hematopoietic Stem Cell Fate by Small Molecules Compounds Recent progress toward the use of small molecule compounds (SMCs) in hematopoietic stem cell research is presented. The authors focus on the significant applications of SMCs related to hematopoietic stem/progenitor cell expansion and discuss the associated mechanism. [Stem Cells Dev] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSCreative Medical Technology Holdings, Inc. announced initiation of a program aimed at treating cancer associated wasting, through the in-licensing of patent application #15/814284 entitled “Treatment of Cachexia Using Stem Cells and Products Thereof“. [Creative Medical Technology Holdings, Inc. (PR Newswire Association LLC.).] Press Release BioBridge Global Announces Formation of Regenerative Medicine Advisory Board BioBridge Global announced the formation of a new Regenerative Medicine Advisory Board, composed of industry leaders with a wide range of scientific, product development and business experience, to support the organization’s continued growth in regenerative medicine. [BioBridge Global] Press Release | |
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POLICY NEWSIt’s Time to Burst the Biomedical Bubble in UK Research A new study calls for a rebalancing of research and innovation funding to better meet the UK’s economic, social and health needs. [The Guardian] Editorial UK Politicians Propose New “Research Integrity” Watchdog Members of the UK Parliament are calling for the establishment of a new regulatory body to oversee academic research integrity and help prevent misconduct, according to a report published by the House of Commons’s Science and Technology Committee. The proposed “national research integrity committee” would be responsible for tightening up existing UK rules on research integrity for publicly funded universities and, in particular, making sure that institutions are complying with them. [The Scientist] Editorial Chinese Researchers to Get More Autonomy Over Lab Spending Chinese Premier Li Keqiang says the country will ease restrictive rules governing how research funds are used, and cut red tape for researchers. Revised rules are designed to help researchers focus on their work and compete with their counterparts globally. [Nature News] Editorial Research charity launches $330M initiative to fund high-risk life sciences projects One of the world’s largest biomedical research charities is setting up a new $330 million initiative to fund high-risk projects — an effort it hopes can help researchers challenge the status quo in the life sciences. [STAT] Editorial
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EVENTSNEW World Advanced Therapies and Regenerative Medicine Congress 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Position – Cancer Drug Discovery (University of Michigan) Postdoctoral Position – Hematology (Uppsala University) Postdoctoral Associate – Cancer Biology (Trustees of Boston University Medical Campus) Postdoctoral Fellow Positions – Hematopoietic Stem Cell Biology (Nationwide Children’s Hospital) Research Fellow – Epigenetics and Hematology (University of Edinburgh) PhD Student – Cellular Immunotherapy (Glycostem Therapeutics) Postdoctoral Fellowship – Myeloid Tumors (St. Jude Children’s Research Hospital) Postdoctoral Positions – Cell Biology (Children’s Hospital of Philadelphia) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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