Cord Blood News 10.28 July 19, 2018 | |
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TOP STORYInvestigators report that specific HDAC5 inhibition highly upregulated CXCR4 surface expression in human cord blood hematopoietic stem cells and progenitor cells. This resulted in enhanced SDF-1/CXCR4-mediated chemotaxis and increased homing to the bone marrow environment, with elevated SCID-repopulating cell frequency and enhanced long-term and secondary engraftment in NSG mice. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Human umbilical cord-derived MSC (hUC-MSC) infusion exerted anti-diabetic effects and significantly promoted islet recovery in type 2 diabetic mice. Pancreatic inflammation was remarkably suppressed, and local M1 macrophages were directed toward an anti-inflammatory M2-like state after hUC-MSC infusion. [Cell Death Dis] Full Article Two murine chronic graft-versus-host disease (CGVHD) models were utilized to evaluate the effectiveness of ex-vivo cultured hCB-MDSCs in CGVHD. Increased production of IL-17 and more infiltration of T cells and macrophages in CGVHD mice were markedly reduced after hCB-MDSCs treatment. [Biol Blood Marrow Transplant] Abstract 1 × 107 umbilical cord-derived MSCs, loaded onto a collagen scaffold, were transplanted into the uterine cavity following an adhesion separation procedure. A histological study showed the upregulation of estrogen receptor α, vimentin, Ki67 and von Willebrand factor expression levels and the downregulation of ΔNP63 expression level, which indicated an improvement in endometrial proliferation, differentiation and neovascularization following treatment. [Stem Cell Res Ther] Full Article Exosomes from Acellular Wharton’s Jelly of the Human Umbilical Cord Promotes Skin Wound Healing Researchers showed that exosomes isolated from acellular gelatinous Wharton’s jelly enhanced cell viability and cell migration in vitro and enhanced skin wound healing in the punch biopsy wound model in mice. Mass spectrometry analysis revealed that exosomes of Wharton’s jelly umbilical cord contained a large amount of alpha-2-macroglobulin, a protein which mimics the effect of acellular gelatinous Wharton’s jelly exosomes on wound healing. [Stem Cell Res Ther] Full Article Scientists assessed the therapeutic paracrine effects of human umbilical cord-derived MSCs in the cell model of irradiation myocardial fibrosis. The conditioned medium of UC-MSCs promoted cell viability, reduced collagen deposition as measured by Sircol assay and qPCR, prevented oxidative stress and increased antioxidant status, and reduced pro-fibrotic TGF-β1, IL-6 and IL-8 levels. [J Radiat Res] Full Article Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSInvestigators discuss a “hMSC checklist” as a guide to establishing which identity and potency assays to implement when studying human MSCs (hMSCs). The checklist includes markers, differentiation potential, proliferation & growth, attachment & migration, genomic stability and paracrine activity. [Stem Cells Dev] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSGamida Cell announced that the FDA has granted orphan drug designation for NiCord as a treatment for hematopoietic stem cell transplantation. [Gamida Cell] Press Release Nohla Therapeutics announced that the FDA has granted Nohla’s lead product candidate, Dilanubicel (NLA101), orphan drug designation for reduction of morbidity and mortality associated with hematopoietic stem cell transplant. [Nohla Therapeutics] Download Press Release U.S. FDA Approves Terumo BCT’s Sodium Citrate 4% w/v Anticoagulant Solution Amid Shortage The FDA approved Terumo BCT’s Sodium Citrate 4% w/v Anticoagulant Solution USP, indicated for anticoagulating whole blood during automated apheresis procedures. [Terumo BCT, Inc. (Globe Newswire, Inc.)] Press Release | |
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POLICY NEWSOnline Portal of Thousands of Clinical Trials Could Aid Disease Research Under pressure to be more transparent about the results of drug testing studies, some companies have begun to share anonymized patient data from clinical trials with approved researchers on secure websites. An online platform launched aims to expand such efforts by offering a one-stop clearinghouse for those seeking to mine these data for new insights. [ScienceInsider] Editorial Dutch Publishing Giant Cuts Off Researchers in Germany and Sweden Elsevier stopped thousands of scientists in Germany from reading its recent journal articles, as a row escalates over the cost of a nationwide open-access agreement. The move comes just two weeks after researchers in Sweden lost access to the most recent Elsevier research papers, when negotiations on its contract broke down over the same issue. [Nature News] Editorial New Policy Aims to Free Scientists to Focus on Research, Avoid Jumping through Hoops Chinese scientific researchers are to be evaluated on the valuable contributions they make to their field rather than their number of published papers or academic credentials, according to a new policy issued by China’s top officials. The new policy is considered by experts to be the first volley of China’s resistance to efforts by the U.S. to suppress its high-tech development. [Chinanews.com] Editorial
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EVENTSNEW Gordon Research Conference: Vascular Cell Biology Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Assistant or Associate Professor – Stem Cell Transplantation (Dana-Farber Cancer Institute) NEW Scientific Research Positions – Various Subjects (Shanghai General Hospital) Postdoctoral Position – Cancer Drug Discovery (University of Michigan) Postdoctoral Position – Hematology (Uppsala University) Postdoctoral Associate – Cancer Biology (Trustees of Boston University Medical Campus) Postdoctoral Fellow Positions – Hematopoietic Stem Cell Biology (Nationwide Children’s Hospital) PhD Student – Cellular Immunotherapy (Glycostem Therapeutics) Postdoctoral Fellowship – Myeloid Tumors (St. Jude Children’s Research Hospital) Postdoctoral Positions – Cell Biology (Children’s Hospital of Philadelphia) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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