Cord Blood News Volume 10.38 | Sep 27 2018

TOP STORY

Lnk/Sh2b3 Deficiency Restores Hematopoietic Stem Cell Function and Genome Integrity in Fancd2 Deficient Fanconi Anemia

Lnk deficiency restored proliferation and survival of Fancd2^−/− hematopoietic stem cells (HSCs), while reducing replication stress and genomic instability. Deletion of LNK in human fanconi anemia-like HSCs promoted clonogenic growth. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Exosomes Produced from Three-Dimensional Cultures of Mesenchymal Stem Cells by Tangential Flow Filtration Show Higher Yield and Improved Activity

Scientists evaluated mesenchymal stem cells from different sources and found that umbilical cord-derived mesenchymal stem cells produced the highest exosome yield. To optimize exosome production, they cultivated umbilical cord-derived mesenchymal stem cells in scalable microcarrier-based three-dimensional cultures. [Mol Ther] Abstract

Cord Blood-Derived Stem Cells Suppress Fibrosis and May Prevent Malignant Progression in Recessive Dystrophic Epidermolysis Bullosa

Researchers co-cultured cord blood-derived unrestricted somatic stem cells (USSCs) in a transwell with recessive dystrophic epidermolysis bullosa (RDEB) patient-derived fibroblasts, keratinocytes, and cutaneous squamous cell carcinoma, respectively. Although USSC coculture did not inhibit STAT signaling, it significantly suppressed the secretion of matrix metalloproteinase (MMP)-9 and MMP-13, and interferon-γ from RDEB patient-derived cells. [Stem Cells] Abstract | Editorial

Resveratrol Improves Human Umbilical Cord-Derived Mesenchymal Stem Cells Repair for Cisplatin-Induced Acute Kidney Injury

Resveratrol-promoted human umbilical cord-derived MSCs secreted platelet-derived growth factor-DD into renal tubular cells, resulting in downstream phosphorylation of extracellular signal-regulated kinase, which inhibited renal tubular cell apoptosis. [Cell Death Dis] Abstract

Cell Identity, Proliferation, and Cytogenetic Assessment of Equine Umbilical Cord Blood Mesenchymal Stromal Cells

Investigators determined the proliferation capacity, immunophenotype and genome integrity of MSCs from horse umbilical cord blood at passage stage 5 and 10. [Stem Cells Dev] Abstract

A Multicenter Prospective Randomized Controlled Comparative Parallel Study of Dehydrated Human Umbilical Cord (EpiCord) Allograft for the Treatment of Diabetic Foot Ulcers

Healing rates at twelve weeks for subjects treated per protocol were 81% for EpiCord treated and 54% for alginate treated diabetic foot ulcers (DFUs). For those DFUs that received adequate debridement, 96% of the EpiCord treated ulcers healed completely within twelve weeks, compared with 65% of adequately debrided alginate treated ulcers. [Int Wound J] Full Article | Press Release

Imetelstat, a Telomerase Inhibitor, Is Capable of Depleting Myelofibrosis Stem and Progenitor Cells

Treatment of CD34⁺ cells with imetelstat reduced the numbers of myelofibrosis (MF) but not cord blood hematopoietic progenitor cells (HPCs) as well as MF but not normal CD34⁺ALDH⁺ cells irrespective of the patient’s mutational status. The actions of imetelstat on MF hematopoietic stem cells/HPCs were associated with inhibition of telomerase activity and the induction of apoptosis. [Blood Adv] Full Article | Graphical Abstract

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Application of Cord Blood and Cord Blood-Derived Induced Pluripotent Stem Cells for Cartilage Regeneration

The authors provide an overview of the current status of cord blood cells and induced pluripotent stem cells derived from these cells in cartilage regeneration. They also discuss the technical challenges of articular cartilage regeneration and future directions. [Cell Transplant] Full Article

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Geron Announces Discontinuation of Imetelstat Collaboration by Janssen

Geron Corporation announced that Janssen Biotech, Inc. has terminated the 2014 Collaboration and License Agreement with the company. As such, Geron has regained the global rights to develop and commercialize imetelstat, a first-in-class telomerase inhibitor. [Geron Corporation] Press Release

Children Treated with Remestemcel-L Continue to Have Strong Survival Outcomes at Six Months in Mesoblast’s Phase III Trial for Acute Graft versus Host Disease

Mesoblast Limited announced continued strong survival outcomes through day 180 in children with steroid refractory acute graft versus host disease treated with Mesoblast’s Phase III product candidate remestemcel-L, an allogeneic mesenchymal stem cell product candidate. [Mesoblast Ltd (GlobeNewswire, Inc.)] Press Release

France Seeks Slim Rise to Research Budget Amid Spending Cuts

The French government has called for a modest increase to its higher education and research budget for 2019 as it strives to rein in public spending amid a sluggish economic growth forecast. [Nature News] Editorial

Why Chinese Medicine Is Heading for Clinics around the World

For the first time, the World Health Organization will recognize traditional medicine in its influential global medical compendium. [Nature News] Editorial

Science Learns from Its Mistakes Too

Scientific studies should always be published irrespective of their result. That is one of the conclusions of a research project conducted by the German Centre for the Protection of Laboratory Animals at the German Federal Institute for Risk Assessment, the results of which have now been published in the journal PLOS ONE. [EurekAlert!] Editorial

Six Months to Brexit: How Scientists Are Preparing for the Split

The incredible is fast becoming the inevitable. Just six months from now, unless a political earthquake intervenes, the United Kingdom must leave the European Union. Yet the details of the March 2019 break-up are still muddy, and scientists are growing increasingly anxious — and angry — about how Brexit will alter their research and their lives. [Nature News] Editorial

NEW 2019 Transplantation & Cellular Therapy Meetings of ASBMT and CIBMTR
February 20-24, 2019
Houston, Texas, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellowship – Translational Leukemia (Lund University)

NEW Postdoctoral Fellow – Myelodysplasia and Acute Myeloid Leukemia (UNSW)

Professorship – Somatic Gene Therapy (University of Zurich)

Postdoctoral and Research Associate Positions – Chromatin Remodeling Proteins in Normal Stem Cell & Cancer Biology (Johns Hopkins University School of Medicine)

Research Associate – Leukemia and Lymphoma (University College London)

Postdoctoral Fellow – Epigenetics of Hematopoietic Stem Cell Development and Disorders (Nationwide Children’s Hospital)

Bioinformatician – Single Cell Biology and Reprogramming (Lund University Stem Cell Center)

Adjunct Principal Investigator Positions – Molecular Medicine (CeMM and LBI-RUD)

Postdoctoral Researcher – Interdisciplinary (Oregon Health & Science University)

Post-Doctoral Fellow or Research Scientist – Transplant Immunology (Medical College of Wisconsin)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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