Cord Blood News Volume 10.39 | Oct 4 2018

TOP STORY

Reduced-Intensity Conditioning for Hematopoietic Cell Transplant for HLH and Primary Immune Deficiencies

A multicenter prospective Phase II trial of reduced-intensity conditioning with melphalan, fludarabine, and intermediate-timing alemtuzumab was conducted for HLA matched or single HLA locus mismatched related or unrelated donor hematopoietic cell transplantation (HCT) in a largely pediatric cohort. Although the trial demonstrated low early mortality, the majority of surviving patients required donor lymphocyte infusion or second HCT. [Blood] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

A Subset of Paracrine Factors as Efficient Biomarkers for Predicting Vascular Regenerative Efficacy of Mesenchymal Stromal/Stem Cells

Proangiogenic activities in migration and tube formation of endothelial cells and in in vivo Matrigel plug assay were highly consistent with secretion levels of four major factors. Blocking of these four factors by neutralizing antibodies or knockdown of them by siRNA treatment resulted in significant inhibition of proangiogenic activities of not only Wharton’s jelly-derived-MSCs, but also bone marrow-derived MSCs. [Stem Cells] Abstract

The Effect of NIMA Matching in Adult Unrelated Mismatched Hematopoietic Stem Cell Transplantation – A Joint Study of the Acute Leukemia Working Party of the EBMT and the CIBMTR

Fetal exposure to non-inherited maternal antigens (NIMA) may impart lifelong NIMA tolerance modulating the immune response, as shown in adult haploidentical transplantation. In cord blood transplantation, NIMA matching lowered rates of aGvHD and TRM; in haploidentical transplantation, sibling donors with non-shared maternal antigens showed less grade II-IV aGvHD. [Bone Marrow Transplant] Abstract

Successful Engraftment after Cord Blood Transplantation from an HLA-Homozygous Donor (Homo-to-Hetero Cord Blood Transplantation) in a Primary Myelofibrosis Patient with Broad HLA Antibodies

The authors reported the case of a primary myelofibrosis patient with broad human leukocyte antigen (HLA) antibodies who underwent cord blood transplantation (CBT) from an HLA-homozygous donor in which the alleles were matched only in the host-versus-graft direction (homo-to-hetero CBT). [Transfusion] Abstract

Apheresis Causes Complement Deposition on Red Blood Cells (RBCs) and RBC Antigen Alterations, Possibly Inducing Enhanced Clearance

The effect of the plasma- or plateletpheresis procedures by four different devices on the RBCs that were returned to the donor was tested in a blinded, prospective trial in a cohort of twenty five donors. [Transfusion] Abstract

Therapeutic Effects of Umbilical Cord Blood-Derived Mesenchymal Stem Cells Combined with Polydeoxyribonucleotides on Full-Thickness Rotator Cuff Tendon Tear in a Rabbit Model

There was no significant difference in the gross morphologic change of tendon tear between umbilical cord blood-derived-MSCs only and combination with polydeoxyribonucleotide (PDRN) injection in rabbit model of chronic traumatic full-thickness rotator cuff tendon tear. There were no significant differences in the regenerative effects between high and low doses of of PDRN. [Cell Transplant] Full Article

Exosomes Isolated from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Neuroinflammation and Reduce Amyloid-Beta Deposition by Modulating Microglial Activation in Alzheimer’s Disease

Scientists observed that exosomes isolated from human umbilical cord MSCs (hucMSC-exosomes) injection could repair cognitive dysfunctions and help to clear amyloid-β peptide deposition in Alzheimer’s disease mice. They found that hucMSC-exosomes injection could modulate the activation of microglia in brains of the mice to alleviate neuroinflammation. [Neurochem Res] Abstract

Long Non-Coding RNA HULC Affects the Proliferation, Apoptosis, Migration, and Invasion of Mesenchymal Stem Cells

Investigators found that overexpression of highly upregulated in liver cancer (HULC) significantly promoted cell proliferation through promoting cell division and inhibited cell apoptosis. HULC-overexpressed mesenchymal stem cells migrated and invaded faster than control mesenchymal stem cells. [Exp Biol Med (Maywood)] Abstract

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In Vitro Generation of Red Blood Cells for Transfusion Medicine: Progress, Prospects and Challenges

The authors highlight the recent advances to red blood cell (RBC) generation from different approaches and discuss the challenges and new strategies that can potentially make large-scale in vitro generation of RBCs a feasible approach. [Biotechnol Adv] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Be The Match BioTherapies^® and Cryoport Announce Strategic Partnership to Deliver Integrated End-to-End Supply Chain Services to the Cell and Gene Therapy Industry

Be The Match BioTherapies and Cryoport, Inc. announced a strategic partnership to deliver end-to-end supply chain services to the cell and gene therapy industry. The collaboration will support both organizations’ efforts to standardize critical elements of the cell therapy supply chain, as well as processes in apheresis and transplant center networks. [Be The Match BioTherapies] Press Release

Kangstem Biotech Selects Orgenesis’ Subsidiary Masthercell for GMP Manufacturing of Furestem-AD^® in Europe

Orgenesis Inc. announced that Kangstem Biotech Co., Ltd. has selected Orgenesis’ subsidiary, Masthercell Global Inc., as its contract manufacturing partner for the European clinical trials of Furestem-AD^®, a cell therapy designed to treat atopic dermatitis. [Orgenesis Inc.] Press Release

Mr Smits Goes to Washington: Architect of Bold European Open-Access Plan Hopes to Garner US Support

A month after European funders launched the ‘Plan S’ initiative to demand immediate open access to scientific literature in the next two years, the plan’s creators have revealed more details about their bold scheme — and are hurriedly trying to get support from US policymakers. [Nature News] Editorial

At NEJM, a Change at the Top Offers a Chance to Reshape the World’s Oldest Medical Journal

The retirement of Dr. Jeffrey Drazen as editor of the New England Journal of Medicine has created an opportunity to bring a new perspective to what is arguably the world’s most prestigious medical journal. [STAT News] Editorial

Brazil’s Presidential Election Could Savage Its Science

A populist surge from a right-wing presidential candidate in Brazil that is threatening to upend the country’s politics could have huge impacts on research budgets and environmental policies. [Nature News] Editorial

NEW 8^th InterAmerican Oncology Conference
October 17-18, 2019
Buenos Aires, Argentina

Visit our events page to see a complete list of events in the community.

NEW Senior Research Assistant – Stem Cell Transplantation (MD Anderson Cancer Center)

NEW Postdoctoral Associate – Hematopoiesis and Leukemia (The Jackson Laboratory)

Postdoctoral Fellowship – Translational Leukemia (Lund University)

Postdoctoral Fellow – Myelodysplasia and Acute Myeloid Leukemia (UNSW)

Professorship – Somatic Gene Therapy (University of Zurich)

Postdoctoral and Research Associate Positions – Chromatin Remodeling Proteins in Normal Stem Cell & Cancer Biology (Johns Hopkins University School of Medicine)

Postdoctoral Fellow – Epigenetics of Hematopoietic Stem Cell Development and Disorders (Nationwide Children’s Hospital)

Bioinformatician – Single Cell Biology and Reprogramming (Lund University Stem Cell Center)

Postdoctoral Researcher – Interdisciplinary (Oregon Health & Science University)

Post-Doctoral Fellow or Research Scientist – Transplant Immunology (Medical College of Wisconsin)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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