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Pulmonary Cell News| Cord Blood News 10.46 November 22, 2018 | |
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TOP STORYBICD1 Mediates HIF1α Nuclear Translocation in Mesenchymal Stem Cells during Hypoxia Adaptation Scientists investigated the role of a motor adaptor protein bicaudal D homolog 1 (BICD1) in dynein-mediated hypoxia inducible factor 1α (HIF1α) nuclear translocation and the effect of BICD1 regulation on hypoxia adaptation and its therapeutic potential on human umbilical cord blood-derived MSCs. [Cell Death Differ] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)The status of signaling pathways involved in the osteogenic differentiation and the expression profile of integrins in the WJ-derived MSCs (WJ-MSCs) were examined. WJ-MSCs displayed differentiation capacities and expressed surface antigens, characteristics of MSCs. [Artif Cells Nanomed Biotechnol] Abstract Human endometrial stromal cells (ESCs) were cultured with mifepristone to obtain damaged ESCs, which were then cocultured with or without Wharton’s jelly (WJ)-MSCs to observe the reparative effect upon damaged ESCs by WJ-MSCs. [Stem Cell Res Ther] Full Article The authors evaluated the safety of MSC infusions in patients with autoimmune diseases. The mean follow-up period of all patients was 43.4 ± 25.9 months. Majority of stem cells were from the umbilical cord. The most common indications for MSC infusions were systemic lupus erythematosus, Sjögren’s syndrome, and systemic sclerosis. [Stem Cell Res Ther] Full Article Effect of Dentin Matrix Components on the Mineralization of Human Mesenchymal Stromal Cells Researchers showed that low concentration solubilized dentin extracellular matrix components in osteogenic cultures of human umbilical cord (UC) MSCs and dental pulp stromal cells (DPSCs) enhanced mineral deposition, while adipose stromal cells were barely affected. Interestingly, UC-MSCs displayed significantly greater hydroxyapatite formation compared to DPSCs. [Tissue Eng Part A] Abstract To improve the efficiency of graft-versus-host disease (GvHD) prophylaxis in haploidentical peripheral blood stem cell transplantation combined with unrelated cord blood, a novel regimen, which is composed of low dose of anti-thymocyte globulin and low-dose posttransplant cyclophosphamide for GvHD prophylaxis, was evaluated in a prospective Phase II clinical trial [Bone Marrow Transplant] Abstract Investigators showed that non-commercial, simple media formulations with extended storage intervals at 2-10°C temperatures are capable of retaining the characteristics of clinical-grade human umbilical cord multipotent stromal cells. [Cytotherapy] Abstract Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSMyths, Reality and Future of Mesenchymal Stem Cell Therapy In spite of a huge amount of preclinical data that has been accumulated on the therapeutic properties of MSCs, there are many conflicting results, possibly due to differences in the properties of MSCs obtained from different sources or underestimated mechanisms of MSC in vivo behavior. The authors consolidate the in vivo effects of MSC therapy, discuss the fate of MSCs after intravascular and local delivery and propose possible trends in MSC therapy. [Cell Tissue Res] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSCesca Therapeutics Inc. announced that its device subsidiary, ThermoGenesis® Corp., has received 510(k) clearance from the FDA for its proprietary AXP® II AutoXpress® Platform (AXP II) for clinical blood banking. [Cesca Therapeutics Inc.] Press Release Study Aims to Cure Blood Cancers with Transplants That Could Block HIV, Too Thanks to a new federal grant, Fred Hutchinson Cancer Research Center is about to lead a clinical trial offering cord blood transplants to a small group of especially vulnerable patients with blood cancers: those who also have HIV, the virus that causes AIDS. [Fred Hutchinson Cancer Research Center] Press Release | |
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POLICY NEWSStop Exploitation of Foreign Postdocs in the United States A survey reveals some lab heads are using the need for visas to create unacceptable conditions for junior researchers. Some PIs are exploiting the fact that overseas scientists rely on them for continued visas. The responses suggest that senior scientists are using this reliance to force postdocs to work longer hours and endure unacceptable conditions. [Nature News] Editorial To Catch Misconduct, Journals Are Hiring Research Integrity Czars Scientific journals’ creation of dedicated positions for rooting out misconduct before publication comes amid growing awareness of such issues, and stems from a recognition that spot-checking and other ad hoc arrangements were insufficient. [STAT News] Editorial In Reversal, NSF Lifts Proposal Limits on Biologists In a reversal, the National Science Foundation (NSF) will no longer restrict researchers to only one proposal submission per year to the biology directorate’s three core tracks in which they are listed as a principal investigator (PI) or co-PI. [ScienceInsider] Editorial
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EVENTSNEW Keystone Symposia: Cell Competition in Development and Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Scientist – Hematologic Malignancies (Mayo Clinic) NEW Process Scientist – Cell Therapy (University College London) Postdoctoral Research Scientist – Hematopoietic Stem Cells (Columbia University Medical Center) Faculty Position – GvHD or Immunotherapy (Medical College of Wisconsin) Senior Research Scientist – Flow Cytometry (MD Anderson Cancer Center) Research Scientist – Hematological Malignancies (MD Anderson Cancer Center) Postdoctoral Fellow – Blood Development & Disease (University of Washington) Senior Research Assistant – Stem Cell Transplantation (MD Anderson Cancer Center) Postdoctoral Associate – Hematopoiesis and Leukemia (The Jackson Laboratory) Postdoctoral Fellowship – Translational Leukemia (Lund University) Postdoctoral Fellow – Myelodysplasia and Acute Myeloid Leukemia (UNSW) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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