Cord Blood News Volume 10.47 | Nov 29 2018

TOP STORY

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

The authors cataloged mutations in the genomes of human-bone-marrow-derived and umbilical-cord-blood-derived hematopoietic stem and progenitor cells. They found that mutations accumulate gradually during life with approximately 14 base substitutions per year. [Cell Rep] Full Article | Press Release | Graphical Abstract

(Ranked by impact factor of the journal)

The Small-Molecule Compound AC-73 Targeting CD147 Inhibits Leukemic Cell Proliferation, Induces Autophagy and Increases the Chemotherapeutic Sensitivity of Acute Myeloid Leukemia Cells

Scientists analyzed CD147 expression and function in hematopoietic progenitor cells from normal cord blood, in several leukemic cell lines and in primary leukemic blasts obtained from patients with acute myeloid leukemia. They investigated the effects of AC-73, used alone or in combination with arabinosylcytosine and arsenic trioxide, on leukemic cell proliferation. [Haematologica] Abstract | Full Article

Risk Factors Affecting Outcome of Unrelated Cord Blood Transplantation for Children with Familial Hemophagocytic Lymphohistiocytosis

Umbilical cord blood transplantation with a high cell dose and good HLA match was a suitable alternative option to hematopoietic stem cell transplantation in children with familial hemophagocytic lymphohistiocytosis who lack a HLA‐matched donor. [Br J Haematol] Abstract

Impact of Graft‐versus‐Lymphoma Effect on Outcomes after Reduced Intensity Conditioned‐Alemtuzumab Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Mature Lymphoid Malignancies

Investigators demonstrated good long‐term outcomes and supported the concept of the graft‐vs‐lymphoma effect as a key protective factor against relapse following reduced‐intensity conditioning‐alemtuzumab allogeneic hematopoietic stem cell transplant for patients with mature lymphoid malignancies. [Br J Haematol] Abstract

Human UCB-MSCs Treatment upon Intraventricular Hemorrhage Contributes to Attenuate Hippocampal Neuron Loss and Circuit Damage through BDNF-CREB Signaling

Researchers showed that treatment with human umbilical cord blood (UCB)-derived MSCs attenuated neuronal loss and promoted neurogenesis in the hippocampus, an area highly vulnerable to intraventricular hemorrhage-induced brain injury. [Stem Cell Res Ther] Full Article

Direct Transdifferentiation of Human Wharton’s Jelly Mesenchymal Stromal Cells into Cholinergic-Like Neurons

Human Wharton’s Jelly MSCs cultured with cholinergic-N-Run medium differentiated into cholinergic-like neurons in four days as evidenced by high levels of protein expression of the neuronal markers ChAT, VAChT, AChE, MAP2, β-Tubulin III, NeuN, TUC-4, NF-L and no expression of the immature marker SOX2, the dopaminergic marker TH, GABAergic marker GAD67 and glial marker GFAP. [J Neurosci Methods] Abstract | Graphical Abstract

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Mesenchymal Stem Cell-Derived Extracellular Vesicles Affect Disease Outcomes via Transfer of MicroRNAs

The authors summarize the mechanism and role of miRNA transfer in mediating the effects of MSC-extracellular vesicles in the models of human diseases. [Stem Cell Res Ther] Full Article

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Weill Cornell Medicine Awarded $9M Grant for Lymphoma Research

Weill Cornell Medicine has been awarded a five-year, $9 million Program Project Grant from the National Cancer Institute to better understand how and why patients with an aggressive and incurable form of lymphoma initially respond to treatment, only to relapse over time. [Weill Cornell Medicine] Press Release

Umbilical Cord Blood Cells Studied for Preserving Brain Function in Infants with Congenital Diaphragm Disease

A new clinical trial at The University of Texas Health Science Center at Houston is the first in the world to investigate whether infusing an infant’s own umbilical cord blood cells, or autologous cells, can protect the brain, mitigating the risk of neurodevelopmental challenges in babies with severe congenital diaphragmatic hernia. [The University of Texas Health Science Center] Press Release

Romania Cuts Research Budget for Second Time This Year

The Romanian government has sliced off another €49 million from its research budget, as the ministry for research and innovation failed to put out funding calls to spend all of the €350 million it had allocated for 2018. [Science|Business] Editorial

Some Research May Be Encouraging Ineffective Prescriptions, Says New Study

A new paper published by McGill University researchers in JAMA Internal Medicine suggests that some clinical trials may promote the use of ineffective and costly treatments. That’s the opposite of what clinical trials are aimed at, namely preventing ineffective and costly treatments from being taken up by physicians and patients. [McGill University] Editorial

Researcher Who Created CRISPR Twins Defends His Work but Leaves Many Questions Unanswered

The researcher who set off a global firestorm when he announced the birth of the world’s first gene-edited babies defended his study at a meeting. He Jiankui of the Southern University of Science and Technology in nearby Shenzhen, China, said he was “proud” of the work, which he said could lead to disease prevention “for millions of children,” and provided some details about the unpublished research that many scientists and bioethicists—as well as a phalanx of journalists—were clamoring to hear. [ScienceInsider] Editorial

NEW EMBO-EMBL Symposia: Synthethic Morphogenesis: From Gene Circuits to Tissue Architecture
March 17-20, 2019
Heidelberg, Germany

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NEW Tenure Track Assistant Professor – Center for Regenerative Medicine (Massachusetts General Hospital)

NEW Associate Professor/Professor – Regenerative Medicine or Stem Cell Biology (University of Toronto)

NEW Postdoctoral Fellowship – Leukemia (Lund University)

Research Scientist – Hematologic Malignancies (Mayo Clinic)

Process Scientist – Cell Therapy (University College London)

Postdoctoral Research Scholar – Myeloproliferative Neoplasms (Washington University School of Medicine)

Postdoctoral Research Scientist – Hematopoietic Stem Cells (Columbia University Medical Center)

Faculty Position – GvHD or Immunotherapy (Medical College of Wisconsin)

Postdoctoral Fellow – Blood Development & Disease (University of Washington)

Postdoctoral Associate – Hematopoiesis and Leukemia (The Jackson Laboratory)

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