Cord Blood News 10.49 December 13, 2018 | |
| |
TOP STORYScientists evaluated the implication of the tumor necrosis factor-α/sphingomyelinase/ceramide pathway on inhibition of erythropoiesis in human CD34+ hematopoietic stem/progenitor cells from healthy donors. [Cell Death Differ] Full Article | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Paracrine Factors Released by Osteoblasts Provide Strong Platelet Engraftment Properties Limiting dilution transplantation assays revealed that osteoblasts secrete soluble factors that synergize with exogenously‐added cytokines to promote the production of progenitors with short term platelet engraftment activities, and to a lesser extent with long term platelet engraftment activities. [Stem Cells] Abstract Scientists created a new approach to treat type 2 diabetes by inducing prolonged expression of apelin in Wharton’s jelly (WJ)-derived MSCs. Infusion of WJMSCs-apelin not only improved significantly insulin sensitivity and glucose disposal, but also promoted endogenous pancreatic β cell proliferation. [Stem Cell Res Ther] Full Article Researchers investigated the effects of autophagy on the status of the cell, release of anti‐inflammatory factors and migration of umbilical cord (UC)‐derived MSCs in vitro. The therapeutic effects and in vivo migration of rapamycin‐preconditioned UC‐MSCs were observed in a C57/B6 mouse model of liver ischemia/reperfusion injury. [Cell Prolif] Full Article Investigators present the crosslinking of arginyl‐glycyl‐aspartic acid (RGD) on the surface of “real thickness” porous polyurethane scaffolds, to be used for the expansion and osteogenic differentiation of umbilical cord blood MSCs. RGD‐functionalized scaffolds increased initial cell adhesion (1.5‐2‐fold) and achieved a 3.4‐fold increase in cell numbers at the end of culture compared to a 1.5‐fold increase in non‐functionalized controls. [J Tissue Eng Regen Med] Abstract Improved Multilineage Human Hematopoietic Reconstitution and Function in NSGS Mice The authors compared the engraftment and output of umbilical cord blood CD34+ cells in four immune-deficient strains: NOD/SCID (NS), NS with additional IL2RG knockout (NSG), NS with transgenic expression of human myeloid promoting cytokines SCF, GM-CSF, and IL-3 (NSS), and NS with both IL2RG knockout and transgenic cytokine expression (NSGS). Overall engraftment of human hematopoietic cells was highest in the IL2RG knockout strains, while myeloid cell output was notably enhanced in the two strains with transgenic cytokine expression. [PLoS One] Full Article Investigators found that human umbilical cord MSC-derived exosomes can reduce the expression of the NLRP3 inflammasome and downstream inflammatory factors in acute liver failure. [Biochem Biophys Res Commun] Abstract Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
| |
REVIEWSMesenchymal Stromal Cell Therapy: Progress in Manufacturing and Assessments of Potency The authors review recent developments in MSC manufacturing technologies, release testing and potency assays. They conclude that, although MSCs hold considerable promise clinically, economies of scale have yet to be achieved although numerous bioreactor technologies for scalable production of MSCs exist. [Cytotherapy] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
| |
INDUSTRY NEWSTissue Regeneration Therapeutics Inc. and RoosterBio Inc. announced an important strategic alliance to advance their shared goal of accelerating the development of the Regenerative Medicine and Cellular Therapy fields. This collaboration will be focused on applying RoosterBio’s unique scale-up bioprocess systems to TRT’s core technology around human umbilical cord perivascular cells. [Tissue Regeneration Therapeutics Inc.] Press Release Therapeutic Solutions International, Inc. announced the signing of an agreement between TSOI and Jadi Cell LLC for licensing of the Jadi Cell universal donor adult stem cell, as covered in US Patent No.: 9,803,176 B2 for use in chronic traumatic encephalopathy, and traumatic brain injury. The Jadi Cell product, which belongs to the MSC family of cells, is a unique adult stem cell, which produces higher levels of therapeutic factors compared to other stem cells. [Therapeutic Solutions International, Inc. (GlobeNewswire, Inc.)] Press Release | |
| |
POLICY NEWSThe End of DACA Would Be a Blow to Science With the end of Deferred Action for Childhood Arrivals (DACA), undocumented scientists will lose what few protections they currently have under immigrant law, lose their access to their scientific research, and once again live in fear, as they are caught in legal limbo. [Scientific America] Editorial South Korean Scientists Protest Treatment of University President Accused of Misusing Funds Researchers in South Korea have criticized the nation’s science ministry for its handling of an investigation into the president of the Korea Advanced Institute of Science and Technology (KAIST) in Daejon, the country’s top technical university. The science ministry alleges that KAIST leader Shin Sung-Chul made illegal payments to a California lab, but many scientists see a political purge. [Nature News] Editorial Lawsuit Alleges NIH, FDA Let Clinical Trial Sponsors Off the Hook A former top official at the FDA and a longtime science journalist are suing the agency and the National Institutes of Health (NIH), saying they let clinical trial sponsors off the hook for reporting nearly a decade’s worth of important scientific data. [STAT News] Editorial
| |
EVENTSNEW 5th Annual Perinatal Stem Cell Society Congress NEW 3rd International Conference on Stem Cells NEW Tissue Engineering & Regenerative Medicine International Society – AP Chapter and the 7th Asian Biomaterials Congress Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Staff Scientist – Hematology (St. Jude Children’s Research Hospital) Research Officer – Hematopoietic Stem Cells (The University of Queensland) Tenure Track Assistant Professor – Center for Regenerative Medicine (Massachusetts General Hospital) Associate Professor/Professor – Regenerative Medicine or Stem Cell Biology (University of Toronto) Postdoctoral Fellowship – Leukemia (Lund University) Research Scientist – Hematologic Malignancies (Mayo Clinic) Process Scientist – Cell Therapy (University College London) Faculty Position – GvHD or Immunotherapy (Medical College of Wisconsin) Postdoctoral Associate – Hematopoiesis and Leukemia (The Jackson Laboratory) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Cord Blood News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|