Cord Blood News 11.01 January 17, 2019 | |
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TOP STORYScientists retrospectively analyzed 165 adult patients who received myeloablative single-unit cord blood transplantation in their institute. In multivariate analysis, a higher controlling nutritional status score, which is indicative of poor inflammatory and nutritional status, was significantly associated with poor outcomes including low neutrophil engraftment, and development of extensive chronic graft-versus-host disease. [Biol Blood Marrow Transplant] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers previously reported significant improvements in behavior, including increased social functioning, improved communication abilities, and decreased clinical symptoms in children with autism spectrum disorder, following treatment with a single infusion of autologous cord blood in a Phase I open‐label trial. In the current study, they aimed to understand whether these improvements were associated with concurrent changes in brain structural connectivity. [Stem Cells Transl Med] Full Article MSCs were isolated from three neonatal tissues, namely amniotic membrane, umbilical cord, and chorionic plate, from the same donor, and their morphologies, immunophenotypes, trilineage differentiation potentials, global gene expression patterns, and proliferation abilities were systematically compared under chemical-defined serum-free medium. [Stem Cell Res Ther] Full Article Investigators studied Wharton’s jelly mesenchymal stem cells from umbilical cord from mothers without gestational diabetes mellitus (GDM); insulin-controlled GDM mothers and diet-controlled GDM mothers. [Stem Cell Rev] Abstract In Vitro Interaction of Human Wharton’s Jelly Mesenchymal Stem Cells with Biomimetic 3‐D Scaffold Wharton’s jelly mesenchymal stem cells’ behavior on 3‐D biomimetic nano‐hydroxy apatite/chitosan/gelatin scaffolds was investigated. The outcome was assessed by histological, biochemical and morphological tests. [J Biomed Mater Res A] Abstract PKH26-labeled umbilical cord-MSCs and cord blood mononuclear cells were transplanted into rats with hypoxia-ischemia-induced brain damage. Apoptotic cell numbers in the brain, as labeled by TUNEL, were assessed. [Behav Brain Res] Abstract The authors investigated the potential of two different types of mesenchymal stem cells derived from human Wharton’s jelly and nasal cavity for differentiation into dopaminergic neurons. [J Chem Neuroanat] Abstract | Graphical Abstract Scientists investigated the renogenic characteristics of amniotic fluid stem cells and evaluated their in vitro differentiation potential into renal proximal tubular-like cells and juxtaglomerular-like cells. [In Vitro Cell Dev Biol Anim] Abstract Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSThe authors summarize pre-transplant assessment tools in optimizing patient selection and predicting transplant outcomes in older adults, including comorbidity indices, psychosocial assessment, geriatric assessment, serum biomarkers, and disease risk. They also discuss the impact of donor age and clonal hematopoiesis of indeterminate significance on transplant outcomes. [Expert Rev Hematol] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSNYSCF Inks Strategic Partnership with Ngene Therapeutics The New York Stem Cell Foundation (NYSCF) Research Institute announced a partnership with Ngene Therapeutics Inc. to develop new disease treatments that leverage human stem cell research and novel gene editing techniques. [The New York Stem Cell Foundation] Press Release | |
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POLICY NEWSCrash-Out Brexit Looms Larger for Scientists after Deal Rejected A historic defeat for U.K. Prime Minister Theresa May has raised the odds that the United Kingdom will crash out of the European Union in March, a prospect that scientists dread for its potential for disruption to research collaborations and the economy. [ScienceInsider] Editorial German Institutions and Wiley Reach Open-Access Publishing Deal Ater nearly three years of contract negotiations, a consortium of nearly 700 German libraries, research institutes, and universities called Project DEAL has forged an agreement with the scholarly publisher Wiley that moves the publishing industry towards more open access. [The Scientist] Editorial How UK Scientists Are Planning for a Chaotic No-Deal Brexit British scientists are ramping up preparations for a ‘no deal’ Brexit on 29 March — a situation that would instantly affect travel, data collection, clinical trials and crucial laboratory supplies. [Nature News] Editorial
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EVENTSNEW 2nd Annual Meeting of the American Society for Gene & Cell Therapy (ASGCT) NEW 2nd London Stem Cell Network Symposium Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Immunology (Queen Mary University of London) Senior Research Fellow – Iron Research (New York Blood Center) Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center) Postdoctoral Fellow – Lung Biology/Lung Immunology (Royal College of Surgeons in Ireland) Associate Senior Lecturer – Regenerative Medicine (Lund University) Research Fellow – Leukemia (University College London) Assistant Professor – Regenerative Medicine (University of British Columbia) Postdoctoral Researcher – Leukemia (Karolinska Institutet) Research Associate/Assistant Professor – Hematopoiesis (Pennsylvania State University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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