Cord Blood News Volume 11.02 | Jan 24 2019

TOP STORY

Comparison of Undifferentiated versus Chondrogenic Predifferentiated Mesenchymal Stem Cells Derived from Human Umbilical Cord Blood for Cartilage Repair in a Rat Model

Transplanting undifferentiated umbilical cord blood-derived mesenchymal stem cells (undiff-MSCs) resulted in overall superior cartilage repair as compared with chondrogenic predifferentiated umbilical cord blood-derived-MSCs, hyaluronic acid alone, or no treatment. The articular surfaces of the defect sites in the undiff-MSC group were relatively smoother than those of the other treatments. [Am J Sports Med] Abstract

(Ranked by impact factor of the journal)

Extracellular Vesicles from Human Umbilical Cord Blood Ameliorate Bone Loss in Senile Osteoporotic Mice

Scientists evaluated the therapeutic potential of extracellular vesicles from human umbilical cord blood plasma on senile osteoporosis to clarify the underlying mechanism. [Metabolism] Abstract

Cerebrospinal Fluid from Alzheimer’s Disease Patients as an Optimal Formulation for Therapeutic Application of Mesenchymal Stem Cells in Alzheimer’s Disease

Scientists investigated on the potential of Alzheimer’s disease (AD) patient-cerebrospinal fluid (CSF) samples to be used as a formulation of mesenchymal stem cells (MSCs) and its application in AD therapeutics. When Wharton’s jelly-derived MSCs (WJ-MSCs) were stored in the CSF of AD patients, the stemness of WJ-MSCs was preserved. [Sci Rep] Full Article

Potential Long-Term Treatment of Hemophilia A by Neonatal Co-Transplantation of Cord Blood-Derived Endothelial Colony-Forming Cells and Placental Mesenchymal Stromal Cells

Researchers sought to determine whether co-transplantation of endothelial colony-forming cells and placenta-derived mesenchymal stromal cells could achieve long-term engraftment and Factor VIII expression. [Stem Cell Res Ther] Full Article

Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Enhance Fracture Healing through HIF‐1α‐Mediated Promotion of Angiogenesis in a Rat Model of Stabilized Fracture

The authors investigated whether exosomes derived from umbilical cord mesenchymal stem cells could enhance fracture healing as primary factors by promoting angiogenesis. [Cell Prolif] Full Article

DNMT Inhibitors Effectively Induce Gene Expression Changes Suggestive of Cardiomyogenic Differentiation of Human Amniotic Fluid‐Derived Mesenchymal Stem Cells via Chromatin Remodeling

Investigators evaluated in vitro differentiation initiation of amniotic fluid‐derived mesenchymal stem cells into cardiac progenitors upon application of inhibitors of DNA methyltransferases (DNMT), such as Decitabine and Zebularine. [J Tissue Eng Regen Med] Abstract

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The Future State of Newborn Stem Cell Banking

The authors describe the relevance of newborn stem cell banking and how the cells stored can be utilized as starting material for the next generation of advanced cellular therapies and personalized medicine. [J Clin Med] Full Article

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Gamida Cell Announces Data from NAM-NK and NiCord^® Programs to Be Presented

Gamida Cell Ltd. announced that new data from its clinical programs will be presented. [Press release from Gamida Cell Ltd. discussing research to be presented at the 2019 Transplantation & Cellular Therapy (TCT) Meetings of American Society for Blood and Marrow Transplantation (ASBMT) and Center for International Blood and Marrow Transplant Research (CIBMTR), Houston] Press Release

STEMCELL Technologies Launches mTeSR™ Plus, a Next-Generation Culture System for Human ES and iPS Cell Maintenance

STEMCELL Technologies has released mTeSR™ Plus, an enhanced version of mTeSR™1, the most widely published feeder-free human pluripotent stem cell maintenance medium. The new medium has undergone successful beta testing with several members of the Stem Cell COREdinates group and has completed rigorous in-house validation testing. [STEMCELL Technologies, Inc.] Press Release

CBMG’s AlloJoin^® Therapy for Knee Osteoarthritis (KOA) Becomes the First Stem Cell Drug Application Approved in China for Phase II Clinical Trials

Cellular Biomedicine Group, Inc. announced that its off-the-shelf allogeneic adipose-derived mesenchymal progenitor cell AlloJoin^® therapy for KOA has been approved as the first stem cell KOA drug application in China for a Phase II clinical trial. [Cellular Biomedicine Group, Inc.] Press Release

Brazil’s New President Has Scientists Worried. Here’s Why

Brazil has long been a frontrunner in climate change policy and environmental diplomacy. The international conventions on climate change and biological diversity, for example, were born during the historic United Nations Earth Summit in Rio de Janeiro in 1992, and Brazil played a key role in crafting and implementing both agreements. That legacy is now at risk. [Science Insider] Editorial

Number of EU Research Students in Britain Drops from Pre-Referendum High

The number of postgraduate researchers at UK universities who come from other European Union countries has fallen since the Brexit referendum in June 2016. [Nature News] Editorial

CRISPR-Baby Scientist Fired by University

The scientist who announced last year that he had produced the world’s first gene-edited babies has been fired by his university. [Nature News] Editorial

NEW 2019 International Society for Cellular Therapy (ISCT)
May 29-June 1, 2019
Melbourne, Australia

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Scholar – Pediatric Hematology/Oncology (Pennsylvania State University)

NEW Assistant, Associate, or Professor – Regenerative Medicine (University of Louisville)

Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine)

Postdoctoral Research Fellow – Immunology (Queen Mary University of London)

Senior Research Fellow – Iron Research (New York Blood Center)

Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center)

Associate Senior Lecturer – Regenerative Medicine (Lund University)

Research Fellow – Leukemia (University College London)

Assistant Professor – Regenerative Medicine (University of British Columbia)

Research Associate/Assistant Professor – Hematopoiesis (Pennsylvania State University)

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