Cord Blood News 11.04 February 7, 2019 | |
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TOP STORYResearchers showed that a single dose of a CD117-antibody-drug-conjugate to saporin led to > 99% depletion of host hematopoietic stem cells, enabling rapid and efficient donor hematopoietic cell engraftment. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists compared 334 consecutive fetal liver tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD)-positive vs -negative patients with acute myelogenous leukemia (AML) who underwent haploidentical donor-hematopoietic stem cell transplantation. FLT3-ITD was detected in 39 of 334 patients. [Bone Marrow Transplant] Abstract The authors report the reprogramming of CD34+ cells obtained from UCB of a healthy donor female child belonging to the Indian ethnic population. These CD34+ cells were subjected to nucleofection for delivery of episomal vectors expressing Oct4, Sox2, L-Myc, Lin28, Klf4 and p53DD. [Stem Cell Res] Abstract Scientists report a more detailed quantitative histological, immunohistochemical, and genomic evaluation of biopsies from excisional and diabetic wounds in an attempt to understand the mechanisms of the enhanced wound healing aided by human umbilical cord Wharton’s jelly stem cells. [J Cell Biochem] Abstract After co-culture of umbilical cord blood mesenchymal stem cells and phorbol 12-myristate 13-acetate-activated human THP-1 cells using a transwell system, researchers showed that lipopolysaccharide significantly induced increases in the expression levels of interleukin 10, interleukin 37, phospho-PI3K, and phospho-Akt in macrophages. [Inflammation] Abstract Phthalates Affect the In Vitro Expansion of Human Hematopoietic Stem Cell The authors evaluated the effect of four phthalates: dibutyl phthalate, benzyl butyl phthalate, diethyl phthalate and diethylhexyl phthalate on the in vitro expansion of human hematopoietic cells from umbilical cord blood. [Cytotechnology] Abstract Investigators utilized the anti-inflammatory potential of Wharton’s jelly mesenchymal stem cells to target the inflammasome complex in a rat spinal cord injury model. [J Chem Neuroanat] Abstract Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSThe Spleen May Be an Important Target of Stem Cell Therapy for Stroke In various experimental models, human umbilical cord blood cells, hematopoietic stem cells, bone marrow stem cells, human amnion epithelial cells, neural stem cells and multipotent adult progenitor cells have been shown to reduce the neurological damage caused by stroke. [J Neuroinflammation] Full Article Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSFirst US Patient in Novel Stem Cell Trial for Stroke Disability Enrolled at UTHealth The first U.S. patient to participate in a global study of a stem cell therapy injected directly into the brain to treat stroke disability was enrolled in the clinical trial this week at The University of Texas Health Science Center at Houston (UTHealth). [University of Texas Health Science Center at Houston] Press Release Barts Charity Supports ‘Rising Stars’ of Medical Research with £6m Grant Barts Charity is granting £6 million to fund the ‘Rising Stars’ lectureship program and support the growth of some of the world’s best young medical researchers. [Queen Mary University of London] Press Release | |
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POLICY NEWSNIH Asks Inspector General to Investigate 12 Allegations of Foreign Influence in US Research The National Institutes of Health (NIH) has referred 12 allegations relating to foreign influence over US-funded research to a federal oversight office, Sen. Chuck Grassley said. Grassley, the chairman of the Senate Finance Committee, has repeatedly demanded information from the NIH after the agency revealed in August it was investigating a half-dozen academic institutions — specifically, researchers who may have failed to disclose financial ties to foreign governments. [STAT News] Editorial University of California Staff Researchers Opt to Form a Union, Joining Postdocs After five years as a postdoc—four of them at the University of California, Los Angeles—molecular biologist Christina Priest hit the university’s time limit for postdoctoral appointments and transitioned to a university staff position as a project scientist in the same lab. Now an at-will employee in a job with no set end time, she says she finds her work “continuing the project I initiated as a postdoc … not enormously different, [despite] more responsibility.” [Science Careers] Editorial
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EVENTSNEW 2019 ASCO Annual Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Positions – Cancer Research (Shenzhen University) Postdoctoral Position – Normal and Malignant Hematopoiesis (Karolinska Institutet) Postdoctoral Scholar – Pediatric Hematology/Oncology (Pennsylvania State University) Assistant, Associate, or Professor – Regenerative Medicine (University of Louisville) Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine) Postdoctoral Research Fellow – Immunology (Queen Mary University of London) Senior Research Fellow – Iron Research (New York Blood Center) Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center) Associate Senior Lecturer – Regenerative Medicine (Lund University) Assistant Professor – Regenerative Medicine (University of British Columbia) Research Associate/Assistant Professor – Hematopoiesis (Pennsylvania State University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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