Cord Blood News 11.05 February 14, 2019 | |
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TOP STORYResearchers showed that an anti-human CD117 monoclonal antibody (mAb), SR-1, inhibited normal cord blood and bone marrow hematopoietic stem cells (HSCs) in vitro. Further, SR-1 and clinical-grade humanized anti-human CD117 mAb, AMG 191, depleted normal and myelodysplastic syndrome HSCs in vivo in xenograft mouse models. [Blood] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists demonstrated rapid labeling of umbilical cord-derived mesenchymal stem cells with near-infrared fluorescent CuInS2-ZnS nanocrystals to develop an innovative nano-bioconjugates that exhibit 98% labeling efficiency. [ACS Appl Mater Interfaces] Abstract Investigators used peripheral blood/cord blood and tonsil lymphocytes as a source of human innate lymphoid cells (ILCs). They showed that human ILCs expressed sphingosine-1 phosphate (S1P) receptor 1 mRNA and protein and migrate toward S1P receptor ligands. [Front Immunol] Full Article When equal volumes of different amniotic fluid stem cell derived (AFSV)-extracellular vesicle (EV) preparations were used as treatment in a model of lung epithelial injury, scientists observed a significant variation in how AFSC-EVs were able to protect against cell death. [Sci Rep] Full Article Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) were isolated from umbilical cords and induced with 5‐aza for 14 days. Immunofluorescence staining, real‐time reverse transcription polymerase chain reaction, and western blot of cardiac troponin I and α‐sarcomeric actin on hUCMSCs between days 14 and 0 were performed. [J Cell Physiol] Abstract The authors used a biomaterial, sodium alginate, for the encapsulation of MSCs from the perinatal tissue, Wharton’s jelly (WJMSCs) into microbeads, to study the effect of WJMSCs beads on breast cancer stem cells derived from two breast cancer cell lines, MDA-MB-231 and MCF7. [Int J Biochem Cell Biol] Abstract Investigators explored the ‘plasticity’ of Wharton’s jelly derived-MSCs using an anti-inflammatory drug-mediated enhanced trans-differentiation into endothelial cells (ECs), based on their observation of temporal decrease in COX-2 expression during trans-differentiation of MSCs into ECs at day 7 and 14 along with mature ECs. [Cytotherapy] Abstract Scientists studied a 50/55% DMSO in 5% dextrose cryopreservation solution as an alternative to DMSO dextran. They showed that DMSO dextrose cryopreservation solution had better results than the standard solution when thawed in an isotonic solution. [Vox Sang] Abstract An Insight into the Whole Transcriptome Profile of Four Tissue-Specific Human Mesenchymal Stem Cells Total transcriptome analysis of human MSCs was performed. MSCs were isolated from two adult sources: bone marrow, adipose tissue and two perinatal sources: umbilical cord and placenta. [Regen Med] Abstract | Graphical Abstract Researchers report five patients with hematologic malignancies who received salvage cord blood transplantation for primary graft failure following a non-total body irradiation regimen using fludarabine, melphalan, and low-dose anti-thymocyte globulin. [Int J Hematol] Abstract Investigators explored whether the therapeutic effect of human umbilical cord mesenchymal stem cells on diabetic ulcer wound was enhanced by the activation of the Wnt signaling pathway. [Eur J Med Res] Full Article Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSHematopoietic Stem Cell Activity and Interactions with the Niche The authors review advances in the understanding of hematopoietic stem cell (HSC) regulation by niches during homeostasis, ageing and cancer, and they discuss their implications for the development of therapies to rejuvenate aged HSCs or niches or to disrupt self-reinforcing malignant niches. [Nat Rev Mol Cell Biol] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSVA Pushing Medical Research and Inventions to Private Sector The US Department of Veterans Affairs (VA) announced a new effort to improve public health by pushing its research and inventions into commercial markets. [U.S. Department of Veterans Affairs (TechLink)] Press Release | |
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POLICY NEWSUS Science Agencies Set for Budget Boost in Deal to Avert Government Shutdown With less than two days to go before the US government runs out of money, lawmakers in Congress are scrambling to pass a budget deal that would give small increases to NASA, the National Science Foundation, the Environmental Protection Agency and many other science agencies. [Nature News] Editorial Hungarian Researchers Protest against Government Changes to Funding Thousands of scientists took to the streets in Hungary to protest changes to government research funding. The demonstrations, which saw people hold books above their heads and form a human chain around Budapest’s Academy of Sciences building, are just the latest in a series of clashes between researchers and the country’s populist government over academic freedom. [The Scientist] Editorial Draft Federal Spending Deal Includes Largest Boost for FDA in Five Years A government funding deal released includes $269 million in new funding for the FDA, which would represent the largest increase the agency has seen in at least five years. With that new funding, the FDA would receive $3.08 billion in government funding for fiscal year 2019. Coupled with roughly $2.5 billion in fees from drug, device, and other regulated companies, FDA’s total budget would be $5.67 billion. [STAT News] Editorial
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EVENTSNEW Gordon Research Conference: Tissue Repair & Regeneration Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Development of Lymphoid Cells (Lund University) Faculty Positions – Cancer Research (Shenzhen University) Postdoctoral Position – Normal and Malignant Hematopoiesis (Karolinska Institutet) Postdoctoral Scholar – Pediatric Hematology/Oncology (Pennsylvania State University) Assistant, Associate, or Professor – Regenerative Medicine (University of Louisville) Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine) Postdoctoral Research Fellow – Immunology (Queen Mary University of London) Senior Research Fellow – Iron Research (New York Blood Center) Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center) Associate Senior Lecturer – Regenerative Medicine (Lund University) Assistant Professor – Regenerative Medicine (University of British Columbia) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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