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Pulmonary Cell News| Cord Blood News 11.06 February 21, 2019 | |
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TOP STORYGenetic Programming of Macrophages Generates an In Vitro Model for the Human Erythroid Island Niche Scientists established an in vitro system to model the human erythroblastic island (EI) niche using macrophages that were derived from human induced pluripotent stem cells, and were also genetically programmed to an EI-like phenotype by inducible activation of the transcription factor, KLF1. [Nat Commun] Full Article | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Umbilical cord blood MSCs were encapsulated in novel oxidized alginate hydrogels functionalized with the glycine-histidine-lysine (GHK) peptide and differentiated towards the osteoblastic lineage. The ADA-GHK hydrogels significantly improved osteogenic differentiation compared to gelatin-containing control hydrogels, as demonstrated by gene expression, alkaline phosphatase activity and bone extracellular matrix deposition. [Acta Biomater] Full Article Scientists investigated secretomes of stromal cells harvested from Hoffa’s fat pad, synovial membrane, umbilical cord and cartilage by quantitative liquid chromatography-mass spectrometry proteomics. [Eur Cell Mater] Abstract | Full Article Researchers evaluated functional recovery and nerve regeneration in rats that received human umbilical cord MSC‐derived extracellular vesicle treatment after nerve transection. [J Cell Mol Med] Full Article The authors aimed to develop an ex vivo regional gene therapy strategy using BMP-2-transduced allogeneic umbilical cord blood (UCB)-MSCs to promote bone repair. To this end, human UCB-MSCs were transduced with a lentiviral vector carrying the cDNA for BMP-2. [Hum Gene Ther] Abstract Researchers uncovered high activity of insulin secretion related signaling pathways for cord blood MSCs and cell adhesion related signaling pathways for umbilical cord MSCs. Expression of a large number of immune related signaling pathways also showed the difference in both cells, implying their distinct immune modulatory functions. [Gene] Abstract The authors investigated the effects of sufentanil and ropivacaine on umbilical cord mesenchymal stem cells. They also determined whether sufentanil attenuated the cytotoxicity of ropivacaine in vitro. [Biosci Trends] Abstract | Full Article Investigators report two cases of JMML who were successfully rescued by HSCT from an HLA‐mismatched parent after development of primary engraftment failure following unrelated CBT. [Pediatr Transplant] Abstract Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSUnveiling Mesenchymal Stromal Cells’ Organizing Function in Regeneration The authors highlight the potential role of MSCs as regeneration organizers and speculate that this function emerges in cell sheets (CSs). This concept shifts the understanding of the therapeutic mechanism underlying a widely known CS-based delivery method for regenerative medicine. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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SCIENCE NEWSGamida Cell Ltd. announced that new data from its NAM-NK and NiCord® programs was presented [Press release from Gamida Cell Ltd. discussing research presented at the 2019 Transplantation & Cellular Therapy (TCT) Meetings of American Society for Blood and Marrow Transplantation and Center for International Blood and Marrow Transplant Research, Houston] Press Release | |
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INDUSTRY NEWSPluristem Enters into Collaboration with NASA to Study PLX Therapeutic Benefits in Space Missions Pluristem Therapeutics Inc. announced a collaboration between the company and NASA’s Ames Research Center to evaluate the potential of Pluristem’s PLX cell therapies in preventing and treating medical conditions caused during space missions. [Pluristem Therapeutics Inc.] Press Release Announcing the 2019 Sloan Research Fellows The Alfred P. Sloan Foundation announced the selection of 126 outstanding US and Canadian researchers as the recipients of the 2019 Sloan Research Fellowships. The fellowships, awarded yearly since 1955, honor early-career scholars whose achievements mark them as among the most promising researchers in their fields. [The Alfred P. Sloan Foundation] Press Release | |
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POLICY NEWSFacebook’s Controversies Now Extend to Health and Medicine Issues The Facebook controversies have come to the world of health and medicine. After last year’s scandals involving Cambridge Analytica and Russian trolls, this time the controversies concern anti-vaccine information and health privacy. [STAT News] Editorial Nearly Half of US Female Scientists Leave Full-Time Science After First Child More than 40% of women with full-time jobs in science leave the sector or go part time after having their first child, according to a study of how parenthood affects career trajectories in the United States. By contrast, only 23% of new fathers leave or cut their working hours. [Nature News] Editorial Australia Dials Back Effort to Control ‘Dual Use’ Research A review of Australian export laws has pushed back against the government’s effort to tighten controls on technologies and research that might have dual military and non-military uses. Australian researchers, who were concerned that sweeping controls would restrict collaborative research, have welcomed the findings. [Nature News] Editorial Trump Science Adviser Calls for More Collaboration between Industry and Government Kelvin Droegemeier, newly minted science adviser to US President Donald Trump, wants industry to take a larger role in funding research, with the ultimate goal of ushering in a “second golden era” of US science. [Nature News] Editorial
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EVENTSNEW 24th Congress of the European Hematology Association (EHA) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Experimental Hematology (Leipzig Universitätsklinikum) Postdoctoral Research Fellow – Development of Lymphoid Cells (Lund University) Faculty Positions – Cancer Research (Shenzhen University) Postdoctoral Position – Normal and Malignant Hematopoiesis (Karolinska Institutet) Postdoctoral Scholar – Pediatric Hematology/Oncology (Pennsylvania State University) Assistant, Associate, or Professor – Regenerative Medicine (University of Louisville) Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine) Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center) Associate Senior Lecturer – Regenerative Medicine (Lund University) Assistant Professor – Regenerative Medicine (University of British Columbia) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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