Cord Blood News Volume 11.09 | Mar 14 2019

TOP STORY

Are Amniotic Fluid Products Stem Cell Therapies? A Study of Amniotic Fluid Preparations for Mesenchymal Stem Cells with Bone Marrow Comparison

Mesenchymal stem cells (MSCs) could not be identified in the commercial amniotic fluid products or the unprocessed amniotic fluid. MSCs could be cultured from the bone marrow aspirates. Nucleated cells were found in two products, but most of these cells were dead. [Am J Sports Med] Abstract

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Chromatin-Modifying Agent-Expanded Human Cord Blood Cells Display Reduced Allostimulatory Capacity

Culturing 5-aza-2′-deoxycytidine (5azaD)/trichostatin A (TSA)-expanded cord blood cells in extended cultures revealed that they were still capable of generating dendritic cells. Notably, STAT3 inactivity was transient because the transcript levels of STAT3 and its inhibitors, including SHP1, were comparable between 5azaD/TSA and control cultures following extended culture. [J Immunol] Abstract

Human Serum Enhances the Proliferative Capacity and Immunomodulatory Property of MSCs Derived from Human Placenta and Umbilical Cord

Placenta-derived mesenchymal stromal cells (MSCs) and umbilical derived-MSCs were isolated and cultured in human serum- or fetal bovine serum-supplemented media. The MSC characteristics, including morphology, immunophenotype, and differentiation ability, were verified. [Stem Cell Res Ther] Full Article

Umbilical Cord Blood versus Mesenchymal Stem Cells for Inflammation-Induced Preterm Brain Injury in Fetal Sheep

Researchers aimed to compare the neuroprotective benefits of umbilical cord blood versus mesenchymal stem cells (MSCs) in a large animal model of inflammation-induced preterm brain injury. They hypothesized that MSCs would afford greater neuroprotection. [Pediatr Res] Abstract

HLA-A, -B, -C, -DRB1 and -DQB1 Allele and Haplotype Frequencies of 1463 Umbilical Cord Blood Units Typed in High Resolution from Bogotá, Colombia

Allele and haplotype frequencies were calculated from 1463 unrelated umbilical cord blood units from Bogotá, Colombia typed in high resolution. [Hum Immunol] Abstract

Transplantation of Umbilical Cord-Derived Mesenchymal Stem Cells on a Collagen Scaffold Improves Ovarian Function in a Premature Ovarian Failure Model of Mice

Collagen scaffold loaded with human umbilical cord-derived mesenchymal stem cells transplantation in premature ovarian failure mice preserved ovarian function, as supported by increased estrogen and anti-Mullerian hormone levels, increased ovarian volume, and an increased number of antral follicles. [In Vitro Cell Dev Biol Anim] Abstract

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Mesenchymal Stem Cells for Restoration of Ovarian Function

The author summarizes recent research into potential applications of mesenchymal stem cells in women with infertility or primary ovarian insufficiency, including cases where these conditions are induced by anticancer therapy. [Clin Exp Reprod Med] Full Article

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Pluristem Therapeutics Announces Completion of 2^nd Cohort and DSMB Approval to Enroll Final Cohort in Phase I Hematological Study of PLX-R18

Pluristem Therapeutics, Inc. announced that the company has fully enrolled the second cohort of six patients in its ongoing Phase I clinical study evaluating PLX-R18 for the treatment of incomplete hematopoietic recovery following hematopoietic cell transplantation, and has received Data and Safety Monitoring Board approval to continue to the final cohort of the study. [Pluristem Therapeutics, Inc.] Press Release

Norway Joins List of Countries Canceling Elsevier Contracts

Norway has become latest country to cancel its contracts with Elsevier following a dispute over access to research papers. In a statement published March 12, the Norwegian Directorate for ICT and Joint Services in Higher Education and Research, which represents a consortium of research institutions in the country, rejected Elsevier’s offer to lower some of its costs for Norwegian institutions because it didn’t go far enough to promote free access to published research. [The Scientist] Editorial

In a First, US Private Sector Employs Nearly as Many PhDs as Schools Do

The job market for US science and engineering PhDs is about to pass a long-anticipated milestone. For decades, educational institutions have been the largest employer of PhDs. In 1997, for instance, they eclipsed private sector employment by 11 percentage points, according to the US National Science Foundation’s biennial Survey of Doctorate Recipients. [ScienceInsider] Editorial

NEW FEBS: From Molecules to Living Systems
July 6-11, 2019
Krakow, Poland

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NEW Tissue Bank Technician – Hematology (University of Oxford)

NEW Laboratory and Clinical Studies Manager – Hematology (University of Oxford)

Postdoctoral Position – Stem Cells and Erythropoiesis (Karolinska Institutet)

Assistant Professor – Computational Biology/Stem Cell Biology (University of Illinois at Chicago)

Postdoctoral Scholarship – Proteomics and Erythropoiesis (Lund University)

Postdoctoral Position – Experimental Hematology (Leipzig Universitätsklinikum)

Postdoctoral Research Fellow – Development of Lymphoid Cells (Lund University)

Faculty Positions – Cancer Research (Shenzhen University)

Assistant, Associate, or Professor – Regenerative Medicine (University of Louisville)

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