Cord Blood News Volume 11.10 | Mar 21 2019

TOP STORY

Extracellular Vesicles from Interferon-γ-Primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli-Induced Acute Lung Injury in Rats

The authors investigated whether interferon-γ-primed umbilical cord MSCs would generate MSC-derived extracellular vesicles with enhanced effects in E. coli pneumonia. [Anesthesiology] Abstract

(Ranked by impact factor of the journal)

Comparison of Human Isogeneic Wharton’s Jelly MSCs and iPSC-Derived MSCs Reveals Differentiation-Dependent Metabolic Responses to IFNG Stimulation

To explore differences between native MSCs and iPSC-derived MSCs, researchers developed isogeneic lines from Wharton’s jelly from the umbilical cords of two donors under xeno-free conditions. [Cell Death Dis] Full Article

Comparison of Graft-Acquisition and Early Direct Charges of Haploidentical Related Donor Transplantation versus Umbilical Cord Blood Transplantation

Scientists conducted a retrospective study to evaluate and compare the early costs and charges of haploidentical related donor hematopoietic cell transplants (haplo-HCTs) and double UCB transplants (dUCBTs) in the first 100 days at two US transplant centers. Forty-nine recipients of haplo-HCTs and 37 with dUCBTs were included in the analysis. [Biol Blood Marrow Transplant] Abstract

A Comprehensive Characterization of Large-Scale Expanded Human Bone Marrow and Umbilical Cord Mesenchymal Stem Cells

Investigators used the closed Quantum^® hollow fiber bioreactor to expand four cultures each of MSCs derived from bone marrow and, for the first time, umbilical cords and assessed extensive characterization profiles for each, compared to parallel cultures grown on tissue culture plastic. [Stem Cell Res Ther] Full Article

Peripheral Infusion of Human Umbilical Cord Mesenchymal Stem Cells Rescues Acute Liver Failure Lethality in Monkeys

Scientists treated monkeys with peripheral delivery of human umbilical MSCs (hUC-MSCs) and investigated the role of hUC-MSCs in modulating the progress of acute liver failure. [Stem Cell Res Ther] Full Article

Human Umbilical Cord-Derived Mesenchymal Stem Cells Enhanced HK-2 Cell Autophagy through MicroRNA-145 by Inhibiting the PI3K/AKT/mTOR Signaling Pathway

Investigators regulated miR-145 expression in HK-2 cells, or co-cultured human umbilical cord-derived-MSCs with HK-2 cells and studied the autophagic activity in HK-2 cells to explore the underlying mechanism. [Exp Cell Res] Abstract

Hypoxia/Hypercapnia Prevents Iron-Dependent Cold Injuries in Cord Blood Stem and Progenitor Cells

The authors tested if hypoxic/hypercapnic-induced cytoprotection in cold conditions was associated with the level of labile iron pool and lysosome stability. Cord blood CD34⁺ cells were incubated in air or in the hypoxic/hypercapnic atmosphere for seven days at 4°C and analyzed. [Cytotherapy] Abstract

Increased Opportunity for Prolonged Survival after Allogeneic Hematopoietic Stem Cell Transplantation in Patients Aged 60–69 Years with Myelodysplastic Syndrome

Scientists conducted a nationwide retrospective study to evaluate the outcomes of allogeneic hematopoietic stem cell transplantation in 651 patients aged 60–69 years with de novo myelodysplastic syndrome. [Ann Hematol] Abstract

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Relevance of Oxygen Concentration in Stem Cell Culture for Regenerative Medicine

The authors explore the mechanisms underlying the oxygen signaling pathways and their negatively-associated consequences. This may provide a rationale for culturing stem cells under physiological oxygen concentration for stem cell therapy success, in the field of tissue engineering and regenerative medicine. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Canada’s Stem Cell Network Welcomes Renewed Federal Commitment for Stem Cell & Regenerative Medicine Research

Through Budget 2019, the Government of Canada has signaled its continued confidence in Canadian stem cell and regenerative medicine research with a multi-year investment of $18 million through the Stem Cell Network. [Stem Cell Network] Press Release

Universities Spooked by Trump Order Tying Free Speech to Grants

US President Donald Trump is expected to issue an executive order on 21 March that would require universities to certify that they protect free speech or risk losing federal research funds. The order will apply to 12 research agencies, including the National Institutes of Health, the National Science Foundation, the Department of Energy and NASA, a White House official said. [Nature News] Editorial

EU’s Biggest Research Program Yet Takes Shape

The European Union’s three governing institutions — the Parliament, Council and Commission — reached agreement in the small hours of 20 March on the outline of the EU’s next seven-year research-funding program. [Nature News] Editorial

Canada Budget Overlooks Basic Research

Canada’s 2019 budget, released on 19 March, includes modest increases for Prime Minister Justin Trudeau’s government priorities, including neuroscience and genomics research ― nothing like the historic five-year, Can$4-billion boost for basic science and research unveiled in 2018. [Nature News] Editorial

US Researchers Hope Congress Will Dig NSF Out of a $1 Billion Budget Hole

For the second time in three years, President Donald Trump has recommended deep cuts to the National Science Foundation (NSF) in Alexandria, Virginia. And scientists are hoping Congress will again come to the agency’s rescue. [ScienceInsider] Editorial

NEW Advanced Cell Therapies and Tissue Engineering
November 14-16, 2019
Milan, Italy

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Hematopoietic Stem Cells (Washington University School of Medicine)

NEW Postdoc Fellow Positions – Human iPS cells, Epigenetics, Hematopoietic Stem Cell Biology, and Blood Cancers (Nationwide Children’s Hospital & Ohio State University)

Tissue Bank Technician – Hematology (University of Oxford)

Laboratory and Clinical Studies Manager – Hematology (University of Oxford)

Postdoctoral Position – Stem Cells and Erythropoiesis (Karolinska Institutet)

Assistant Professor – Computational Biology/Stem Cell Biology (University of Illinois at Chicago)

Postdoctoral Scholarship – Proteomics and Erythropoiesis (Lund University)

Postdoctoral Position – Experimental Hematology (Leipzig Universitätsklinikum)

Postdoctoral Research Fellow – Development of Lymphoid Cells (Lund University)

Faculty Positions – Cancer Research (Shenzhen University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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